Protein Alignment hts and Add1

DIOPT Version :10

• Sequence 1: NP_001097377.2
• Gene: hts / 37230
• FlyBaseID: FBgn0263391
• Length: 1833
• Species: Drosophila melanogaster
• Sequence 2: NP_001318011.1
• Gene: Add1 / 11518
• MGIID: 87918
• Length: 795
• Species: Mus musculus
• Alignment Length: 747
• Identity: 258/747 - (34%)
• Similarity: 376/747 - (50%)
• Gaps: 153/747 - (20%)

  Fly     4 VEQPPQNGIDPTAGE---------DDDN-----SKARPADIEQDMREMERRKRVEAIMGSKLFRE 54
            |..||     ||...         |::|     .:....|:.||...||::|||..|:.|..|.|
Mouse    10 VTSPP-----PTTAPHKERYFDRVDENNPEYLRERNMAPDLRQDFNMMEQKKRVSMILQSPAFCE 69

  Fly    55 ELERIVDSARDGGAGASGI--LQQLSDIV---------GVPVSRVGSVFKSSNCMVPINDIRGVE 108
            |||.::......|...:|:  |||::|.:         ..|...:.::..|...:.|:||:||.:
Mouse    70 ELESMIQEQFKKGKNPTGLLALQQIADFMTASVPNVYPAAPQGGMAALNMSLGMVTPVNDLRGSD 134

  Fly   109 SMGYAKGEKILRCKLAATFRLLDLYGWTQGLGAQITARLKVDQEYFLVNPYGLLYHEITASALNK 173
            |:.|.||||:|||||||.:||.||:||:|.:...||.|:..:||:||:.|:||||.|:|||:|.|
Mouse   135 SIAYDKGEKLLRCKLAAFYRLADLFGWSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVK 199

  Fly   174 VDMQGQIVEQGTTNFGGNKSHFVLHSVVHAARPDIRCAIYIGCSPVVAISSLKTGLLPLTKDACV 238
            |::||.||::|:||.|.|::.|.|||.|:|||||.:|.::|......|:|::|.||||::.:|..
Mouse   200 VNLQGDIVDRGSTNLGVNQAGFTLHSAVYAARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALS 264

  Fly   239 LGEITTHAYTG-LFDEEERNRLVRSLGPNSKVILLTNHGALCCGETIEEAFFAACHIVQACETQL 302
            ||::..|.|.| |.||||:..:.::|||.|||::|.|||.:..||::||||:...::|.|||.|:
Mouse   265 LGDVAYHDYHGILVDEEEKILIQKNLGPKSKVLILRNHGLVSVGESVEEAFYYIHNLVVACEIQV 329

  Fly   303 KLLPV--GLDNLVLIPEESRKAIYEQSRRPPEDLEKKFAAVAAAEDGAATAEKDAAEAVPKVGSP 365
            :.|..  |.|||||:.....||   :||.|                |....|..        |||
Mouse   330 RTLASAGGPDNLVLLDPGKYKA---KSRSP----------------GTPAGEGS--------GSP 367

  Fly   366 PKWRVGGAEFEALMRMLDNAGYRTGYIYRHPLIKSDPPKPKNDVELPPAVSSLGYLLEEEELFRQ 430
            |||::|..|||||||||||.||||||.||:|.:: :..|..:|||:|.:|:...:..:
Mouse   368 PKWQIGEQEFEALMRMLDNLGYRTGYPYRYPALR-ERSKKYSDVEVPASVTGHSFASD------- 424

  Fly   431 GIWKKGDI-----------RKGGDRSRWL---------------NSPNVYQKV------------ 457
                 ||.           ::..:::|||               :||....||
Mouse   425 -----GDSGTCSPLRHSFQKQQREKTRWLHSGRGDDASEEGQNGSSPKSKTKVWTNITHDHVKPL 484

  Fly   458 -EVLETGTPDPKKITK--WVAE-GSPTHSTPVRIEDPLQFVPAGTNPREFKRVQQLIKDNRRADK 518
             :.|.:|...|..||.  |..| |..|.::.|    |..|||..|||:|.:.::..|::....|.
Mouse   485 LQSLSSGVCVPSCITNCLWTKEDGHRTSTSAV----PNLFVPLNTNPKEVQEMRNKIREQNLQDI 545

  Fly   519 ISAGPQSHILEGVTWDEASRLKDATVSQAGDHVVMMG------------------AASKGIIQRG 565
            .:|||||.:|.||..|. |.::||.:|...:.:..:.                  .|||.||::.
Mouse   546 KTAGPQSQVLCGVMMDR-SLVQDAPLSDCTETIEGLAEQTFSPAKSVSFRKGELVTASKAIIEKE 609

  Fly   566 FQHNATVYKAPYAKNPFDNVTDDELNEYKRTVERKKKSVHGEYTDT-DFSESEAVLQAGTKKYPQ 629
            :|.:..|  :....|||:.:||.||.||:|.||||:|.......:| :..|.....|:.....|.
Mouse   610 YQPHVIV--STTGPNPFNTLTDRELEEYRREVERKQKGSEENLDETREQKEKSPPDQSAVPNTPP 672

  Fly   630 SEPETEHQVIEIQTQQAPVPRQAEVVLSDDDS 661
            |.|..    :|....|.|..|        |||
Mouse   673 STPVK----LEEDLPQEPTSR--------DDS 692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hts	NP_001097377.2	Aldolase_II	116..323	CDD:238232	103/209 (49%)
Add1	NP_001318011.1	Aldolase_II	145..391	CDD:469663	127/272 (47%)
		PHA03307	645..>766	CDD:223039	13/60 (22%)