DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11961 and ERMP1

DIOPT Version :9

Sequence 1:	NP_001246418.1	Gene:	CG11961 / 37221	FlyBaseID:	FBgn0034436	Length:	891	Species:	Drosophila melanogaster
Sequence 2:	NP_079172.2	Gene:	ERMP1 / 79956	HGNCID:	23703	Length:	904	Species:	Homo sapiens

Alignment Length:	843	Identity:	257/843 - (30%)
Similarity:	436/843 - (51%)	Gaps:	66/843 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 LTIQDEETHPDQFIAERAEKNLRELVSLGPRVVGSRQNEMAALKMLSQ--KMQKIRSGTANDIEV 144
            |.::....|..:|.|.:|...|..:.|:|||..||.:||:..:..|.:  |:.:::|.:.:.|.|
Human    95 LVLRGAAGHRGEFDALQARDYLEHITSIGPRTTGSPENEILTVHYLLEQIKLIEVQSNSLHKISV 159

  Fly   145 DVQVASGSY---VHWSMVNMYQSIQNIVVKISPKNTNSTTYLLVNSHYDSVPAGPGAGDDGSMVA 206
            |||..:||:   ......:.|.:|.|:|||:.|:: .:...:|.|.|:|||...|||.||....:
Human   160 DVQRPTGSFSIDFLGGFTSYYDNITNVVVKLEPRD-GAQHAVLANCHFDSVANSPGASDDAVSCS 223

  Fly   207 TMMEVLRVLAKSDKPLKNPVVFLFNGAEENPLQASHAFITQHKWAKYCKALINLDSCGNGGREIL 271
            .|:||||||:.|.:.|.:.|:|||||||||.|||||.|||||.||...:|.|||::.|.||:|::
Human   224 VMLEVLRVLSTSSEALHHAVIFLFNGAEENVLQASHGFITQHPWASLIRAFINLEAAGVGGKELV 288

  Fly   272 FQSGPNHPWLMKNYRRAIKHPYASTMGEELFQHNFIPSDTDFRIFRDHGSVPGLDMAYTYNGFVY 336
            ||:||.:|||::.|..|.|||:||.:.:|:||...|||||||||:||.|::||:|:|:..||::|
Human   289 FQTGPENPWLVQAYVSAAKHPFASVVAQEVFQSGIIPSDTDFRIYRDFGNIPGIDLAFIENGYIY 353

  Fly   337 HTRHDKAEIFPRGSFQHTGDNLLALVRQIANSPEIENSAKYAKGHTIYFDVMGWFLVFYTETEGV 401
            ||::|.|:.....|.|..|||:||:::.:|.|..:..::||..|:.::|||:|.|::.|....|.
Human   354 HTKYDTADRILTDSIQRAGDNILAVLKHLATSDMLAAASKYRHGNMVFFDVLGLFVIAYPSRIGS 418

  Fly   402 ILNVIVSLVSIGICGYAFKLMSVNSGIKLEKILKKVGHTLLVQILSVVVGAILPVLLGLFMDAVH 466
            |:|.:|.:..:...|..|......:|...:..|..:|.||:....|:|...|:.|    |:..:.
Human   419 IINYMVVMGVVLYLGKKFLQPKHKTGNYKKDFLCGLGITLISWFTSLVTVLIIAV----FISLIG 479

  Fly   467 LPLSWFSNSWLILGLYFTTFFFGLAIVPAL--YFHWTKRDKLPIGQ---RVQLLLHCHCLLLSVL 526
            ..|||:::.::.:.||.|.....:.::..|  .|::.......:|:   .:.|.:|| |.|:::
Human   480 QSLSWYNHFYVSVCLYGTATVAKIILIHTLAKRFYYMNASAQYLGEVFFDISLFVHC-CFLVTL- 542

  Fly   527 TLIFTICGIRSVFVLMLSCLFYTVGLIINIAT----KLHTKDVAWVIPHIVCTVPPFVFFAYFSH 587
                |..|:.|.|:   |.::....|:..:..    |.|.....::..:::....|:::..|...
Human   543 ----TYQGLCSAFI---SAVWVAFPLLTKLCVHKDFKQHGAQGKFIAFYLLGMFIPYLYALYLIW 600

  Fly   588 GFFTTFIPMFGRFGENLNPDLAVAVFSVAVGFLCCGFIIPVLQLFNKSKTIICGLMGITLLC--- 649
            ..|..|.|:.||.|..:.||:.:|........:...:.|..:.|...:|..   ::.:||:|
Human   601 AVFEMFTPILGRSGSEIPPDVVLASILAGCTMILSSYFINFIYLAKSTKKT---MLTLTLVCAIT 662

  Fly   650 FIIAMTPIGFPY-----RPETNVQRFAVLHTKRTFHDAQNKVRRQESGYFIMPQDRRTYTVKNAV 709
            |::..:...|||     .|:.  :|..:.|..|||||.:....:::||.:|...|   ||   .:
Human   663 FLLVCSGTFFPYSSNPANPKP--KRVFLQHMTRTFHDLEGNAVKRDSGIWINGFD---YT---GI 719

  Fly   710 INMT-----LAQRIGSDCDKEIN-CGLPLYNQRWHKTRKNSLW-IPASEPVLGENVPTVLLLSKN 767
            .::|     :...|.:.|::... ||.|.|.......|||  | :||.| |...|.|...|:||.
Human   720 SHITPHIPEINDSIRAHCEENAPLCGFPWYLPVHFLIRKN--WYLPAPE-VSPRNPPHFRLISKE 781

  Fly   768 TVSPTKIRYEMQLSGPNHMALFIQPLNGAKMMDWSFHQAPLRLSFEPPYFIYFSWGVNGDPLKFW 832
            ......|:...:.:||:||:.:::...|:.:..||........|....||:::|.|:.....:||
Human   782 QTPWDSIKLTFEATGPSHMSFYVRAHKGSTLSQWSLGNGTPVTSKGGDYFVFYSHGLQASAWQFW 846

  Fly   833 LEL----EKPNGNWNSSTLELGLGGHWNHHKELITPDFKKFLDSFPHYVDATPWPASFESRIF 891
            :|:    |.|.|     .:.:.:..|:...::..:|......:.||.:...:.|..:::..:|
Human   847 IEVQVSEEHPEG-----MVTVAIAAHYLSGEDKRSPQLDALKEKFPDWTFPSAWVCTYDLFVF 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11961	NP_001246418.1	M28_Fxna_like	91..395	CDD:193497	136/308 (44%)
ERMP1	NP_079172.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..65
ERMP1	NP_079172.2	M28_Fxna_like	104..412	CDD:193497	136/308 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145825
Domainoid	1	1.000	238	1.000	Domainoid score	I2299
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	418	1.000	Inparanoid score	I1816
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59376
OrthoDB	1	1.010	-	-		D152011at33208
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm40549
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	O	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X435
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770