Protein Alignment CG11961 and ERMP1

DIOPT Version :10

• Sequence 1: NP_725876.1
• Gene: CG11961 / 37221
• FlyBaseID: FBgn0034436
• Length: 891
• Species: Drosophila melanogaster
• Sequence 2: NP_079172.2
• Gene: ERMP1 / 79956
• HGNCID: 23703
• Length: 904
• Species: Homo sapiens
• Alignment Length: 843
• Identity: 257/843 - (30%)
• Similarity: 436/843 - (51%)
• Gaps: 66/843 - (7%)

  Fly    82 LTIQDEETHPDQFIAERAEKNLRELVSLGPRVVGSRQNEMAALKMLSQ--KMQKIRSGTANDIEV 144
            |.::....|..:|.|.:|...|..:.|:|||..||.:||:..:..|.:  |:.:::|.:.:.|.|
Human    95 LVLRGAAGHRGEFDALQARDYLEHITSIGPRTTGSPENEILTVHYLLEQIKLIEVQSNSLHKISV 159

  Fly   145 DVQVASGSY---VHWSMVNMYQSIQNIVVKISPKNTNSTTYLLVNSHYDSVPAGPGAGDDGSMVA 206
            |||..:||:   ......:.|.:|.|:|||:.|:: .:...:|.|.|:|||...|||.||....:
Human   160 DVQRPTGSFSIDFLGGFTSYYDNITNVVVKLEPRD-GAQHAVLANCHFDSVANSPGASDDAVSCS 223

  Fly   207 TMMEVLRVLAKSDKPLKNPVVFLFNGAEENPLQASHAFITQHKWAKYCKALINLDSCGNGGREIL 271
            .|:||||||:.|.:.|.:.|:|||||||||.|||||.|||||.||...:|.|||::.|.||:|::
Human   224 VMLEVLRVLSTSSEALHHAVIFLFNGAEENVLQASHGFITQHPWASLIRAFINLEAAGVGGKELV 288

  Fly   272 FQSGPNHPWLMKNYRRAIKHPYASTMGEELFQHNFIPSDTDFRIFRDHGSVPGLDMAYTYNGFVY 336
            ||:||.:|||::.|..|.|||:||.:.:|:||...|||||||||:||.|::||:|:|:..||::|
Human   289 FQTGPENPWLVQAYVSAAKHPFASVVAQEVFQSGIIPSDTDFRIYRDFGNIPGIDLAFIENGYIY 353

  Fly   337 HTRHDKAEIFPRGSFQHTGDNLLALVRQIANSPEIENSAKYAKGHTIYFDVMGWFLVFYTETEGV 401
            ||::|.|:.....|.|..|||:||:::.:|.|..:..::||..|:.::|||:|.|::.|....|.
Human   354 HTKYDTADRILTDSIQRAGDNILAVLKHLATSDMLAAASKYRHGNMVFFDVLGLFVIAYPSRIGS 418

  Fly   402 ILNVIVSLVSIGICGYAFKLMSVNSGIKLEKILKKVGHTLLVQILSVVVGAILPVLLGLFMDAVH 466
            |:|.:|.:..:...|..|......:|...:..|..:|.||:....|:|...|:.|    |:..:.
Human   419 IINYMVVMGVVLYLGKKFLQPKHKTGNYKKDFLCGLGITLISWFTSLVTVLIIAV----FISLIG 479

  Fly   467 LPLSWFSNSWLILGLYFTTFFFGLAIVPAL--YFHWTKRDKLPIGQ---RVQLLLHCHCLLLSVL 526
            ..|||:::.::.:.||.|.....:.::..|  .|::.......:|:   .:.|.:|| |.|:::
Human   480 QSLSWYNHFYVSVCLYGTATVAKIILIHTLAKRFYYMNASAQYLGEVFFDISLFVHC-CFLVTL- 542

  Fly   527 TLIFTICGIRSVFVLMLSCLFYTVGLIINIAT----KLHTKDVAWVIPHIVCTVPPFVFFAYFSH 587
                |..|:.|.|:   |.::....|:..:..    |.|.....::..:::....|:::..|...
Human   543 ----TYQGLCSAFI---SAVWVAFPLLTKLCVHKDFKQHGAQGKFIAFYLLGMFIPYLYALYLIW 600

  Fly   588 GFFTTFIPMFGRFGENLNPDLAVAVFSVAVGFLCCGFIIPVLQLFNKSKTIICGLMGITLLC--- 649
            ..|..|.|:.||.|..:.||:.:|........:...:.|..:.|...:|..   ::.:||:|
Human   601 AVFEMFTPILGRSGSEIPPDVVLASILAGCTMILSSYFINFIYLAKSTKKT---MLTLTLVCAIT 662

  Fly   650 FIIAMTPIGFPY-----RPETNVQRFAVLHTKRTFHDAQNKVRRQESGYFIMPQDRRTYTVKNAV 709
            |::..:...|||     .|:.  :|..:.|..|||||.:....:::||.:|...|   ||   .:
Human   663 FLLVCSGTFFPYSSNPANPKP--KRVFLQHMTRTFHDLEGNAVKRDSGIWINGFD---YT---GI 719

  Fly   710 INMT-----LAQRIGSDCDKEIN-CGLPLYNQRWHKTRKNSLW-IPASEPVLGENVPTVLLLSKN 767
            .::|     :...|.:.|::... ||.|.|.......|||  | :||.| |...|.|...|:||.
Human   720 SHITPHIPEINDSIRAHCEENAPLCGFPWYLPVHFLIRKN--WYLPAPE-VSPRNPPHFRLISKE 781

  Fly   768 TVSPTKIRYEMQLSGPNHMALFIQPLNGAKMMDWSFHQAPLRLSFEPPYFIYFSWGVNGDPLKFW 832
            ......|:...:.:||:||:.:::...|:.:..||........|....||:::|.|:.....:||
Human   782 QTPWDSIKLTFEATGPSHMSFYVRAHKGSTLSQWSLGNGTPVTSKGGDYFVFYSHGLQASAWQFW 846

  Fly   833 LEL----EKPNGNWNSSTLELGLGGHWNHHKELITPDFKKFLDSFPHYVDATPWPASFESRIF 891
            :|:    |.|.|     .:.:.:..|:...::..:|......:.||.:...:.|..:::..:|
Human   847 IEVQVSEEHPEG-----MVTVAIAAHYLSGEDKRSPQLDALKEKFPDWTFPSAWVCTYDLFVF 904

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11961	NP_725876.1	M28_Fxna_like	91..395	CDD:349872	136/308 (44%)
		MFS	<539..>658	CDD:475125	23/125 (18%)
ERMP1	NP_079172.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..65
		M28_Fxna_like	104..412	CDD:349872	136/308 (44%)