Protein Alignment CG11961 and Tfr2

DIOPT Version :10

• Sequence 1: NP_725876.1
• Gene: CG11961 / 37221
• FlyBaseID: FBgn0034436
• Length: 891
• Species: Drosophila melanogaster
• Sequence 2: NP_056614.3
• Gene: Tfr2 / 50765
• MGIID: 1354956
• Length: 798
• Species: Mus musculus
• Alignment Length: 628
• Identity: 129/628 - (20%)
• Similarity: 197/628 - (31%)
• Gaps: 257/628 - (40%)

  Fly    48 GNKIKWFWAPA---------------FFGFWLLLYVTISIPACHRLPRPLTIQDEETHPD----- 92
            |..|...||.|               |.|.:||.||... .:|......:.:.||:.:|:
Mouse    65 GRSIPIPWAAAGRKAAPYLVLITLLIFTGAFLLGYVAFR-GSCQACGDSVLVVDEDVNPEDSGRT 128

  Fly    93 ------------QFIAE-RAEKNLRELVSLGPRVVGSRQNEMAAL------KMLSQKMQKIRSGT 138
                        :|:.| |.|..:| |.||..||.||.:  ||.|      |:..||:..:.:.|
Mouse   129 TLYWSDLQAMFLRFLGEGRMEDTIR-LTSLRERVAGSAR--MATLVQDILDKLSRQKLDHVWTDT 190

  Fly   139 ANDIEVDVQV---ASGSYVHWSMVNMYQSIQNIVVKISPK------NTNSTTYLLVNSHYDSVPA 194
            .   .|.:|.   |..:.:||  |:...|:|..:....|:      .|.:.|..||.:||
Mouse   191 H---YVGLQFPDPAHANTLHW--VDADGSVQEQLPLEDPEVYCPYSATGNATGKLVYAHY----- 245

  Fly   195 GPGAGDD------------GSMVATMMEVL----RVLAKSDKPLKNPVVFL----FNGAEENPLQ 239
              |..:|            ||::...:.:.    :|....|...:..:::.    |:.....|..
Mouse   246 --GRSEDLQDLKAKGVELAGSLLLVRVGITSFAQKVAVAQDFGAQGVLIYPDPSDFSQDPHKPGL 308

  Fly   240 ASHAFITQHKWAKYCKALINLDSCGNG-------------------------------GREILFQ 273
            :||..:..|         ::|   |.|                               ..:|..|
Mouse   309 SSHQAVYGH---------VHL---GTGDPYTPGFPSFNQTQFPPVESSGLPSIPAQPISADIADQ 361

  Fly   274 -----SGPNHPWLMKNYRRAIKHPYASTMGEE--LFQHNFIPSDTDFRIFR--------DHGSV- 322
                 :||..|...|.:...  .||....|.:  |..:|...|.....||.        ||..|
Mouse   362 LLRKLTGPVAPQEWKGHLSG--SPYRLGPGPDLRLVVNNHRVSTPISNIFACIEGFAEPDHYVVI 424

  Fly   323 --------PG-----------LDMAYTY-----NGFVYHTRHDKAEIF---PRGSFQHTGDNLLA 360
                    ||           |::..|:     |||    |..::.:|   ..|.|...|
Mouse   425 GAQRDAWGPGAAKSAVGTAILLELVRTFSSMVSNGF----RPRRSLLFISWDGGDFGSVG----- 480

  Fly   361 LVRQIANSPEIENSAKYAKGHTIYFDVMGWFLVFYTETEGVILN----------VIVSLVSIGIC 415
                         :.::.:|   |..|:....|.|...:..:|.          ::|||:
Mouse   481 -------------ATEWLEG---YLSVLHLKAVVYVSLDNSVLGDGKFHAKTSPLLVSLI----- 524

  Fly   416 GYAFKLMSVNSGIKLEKILKKV------GHTLLVQILSVVVGAILPVLLGLFMDAVHLPLSWFSN 474
                           |.|||:|      |.||..|:..........|:..|.||:     |.:|
Mouse   525 ---------------ENILKQVDSPNHSGQTLYEQVALTHPSWDAEVIQPLPMDS-----SAYS- 568

  Fly   475 SWLILGLYFTTFFFGLAIVPALYFHWTKRDKLPIGQRVQLLLH 517
                    ||.|    |.|||:.|.:.:.|      ||...||
Mouse   569 --------FTAF----AGVPAVEFSFMEDD------RVYPFLH 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11961	NP_725876.1	M28_Fxna_like	91..395	CDD:349872	82/430 (19%)
		MFS	<539..>658	CDD:475125
Tfr2	NP_056614.3	Endocytosis signal. /evidence=ECO:0000255	23..26
		PA_TfR	206..396	CDD:239043	36/212 (17%)
		M28_TfR	404..637	CDD:349946	54/259 (21%)
		TFR_dimer	664..788	CDD:461238