DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11961 and CG10073

DIOPT Version :9

Sequence 1:	NP_001246418.1	Gene:	CG11961 / 37221	FlyBaseID:	FBgn0034436	Length:	891	Species:	Drosophila melanogaster
Sequence 2:	NP_001261090.1	Gene:	CG10073 / 37225	FlyBaseID:	FBgn0034440	Length:	881	Species:	Drosophila melanogaster

Alignment Length:	902	Identity:	362/902 - (40%)
Similarity:	539/902 - (59%)	Gaps:	43/902 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VRRRVITPTNDPTN--VDPLLRPRGSQQYEAQPNGCERAFVQGNKIKWFWAPAFFGFWLLLYVTI 70
            ||.|..|..|..::  ::..:|...|::.:.|     ..:::|   .|:.|..|..||.||:..:
  Fly     5 VRSRFDTCKNKISDEPIEDAVRSASSKKIKNQ-----EQYLRG---PWYLATGFLLFWALLFSAV 61

  Fly    71 SIPACHRLPRPLTIQDEETHPDQFIAERAEKNLRELVSLGPRVVGSRQNEMAALKMLSQKMQKIR 135
            .:|..:|:|..|||:|  .....||||||:.||.:|..:|.:||||..||...:..|...:.:|:
  Fly    62 VLPLFYRIPTGLTIED--ASKGVFIAERAQSNLYKLAEIGTKVVGSDNNENKTVDYLMGLVNEIQ 124

  Fly   136 SGTAN---DIEVDVQVASGSYVHWSMVNMYQSIQNIVVKISPKNTNSTTYLLVNSHYDSVPAGPG 197
            ....:   |||||:|..||||:||:||||||.:||||:|:|||||.||||||||||:||.|..|.
  Fly   125 ENCLDDYFDIEVDLQEVSGSYIHWTMVNMYQGVQNIVIKLSPKNTTSTTYLLVNSHFDSKPTSPS 189

  Fly   198 AGDDGSMVATMMEVLRVLAKSDKPLKNPVVFLFNGAEENPLQASHAFITQHKWAKYCKALINLDS 262
            |||.|.||..::|||||:..:.:.:::|||||.||||||||||||.|||||||||.||.::|||:
  Fly   190 AGDAGQMVVAILEVLRVMCSTKQAIRHPVVFLLNGAEENPLQASHGFITQHKWAKNCKVVLNLDA 254

  Fly   263 CGNGGREILFQSGPNHPWLMKNYRRAIKHPYASTMGEELFQHNFIPSDTDFRIFRDHGSVPGLDM 327
            .||||.:|:||:|||.|||::.|:....|..|:||.||:||...:||||||.||..:|::.||||
  Fly   255 AGNGGSDIVFQTGPNSPWLVEKYKENAPHYLATTMAEEIFQTGILPSDTDFAIFVKYGNLIGLDM 319

  Fly   328 AYTYNGFVYHTRHDKAEIFPRGSFQHTGDNLLALVRQIANSPEIENSAKYAKGHTIYFDVMGWFL 392
            |...|||.|||::|:....||||.|:||||||.|||.||||.|::|:..||.||.|:|||:|.:.
  Fly   320 AKFINGFAYHTKYDQFSNIPRGSIQNTGDNLLGLVRSIANSTELDNTEAYATGHAIFFDVLGLYF 384

  Fly   393 VFYTETEGVILNVIVSLVSIGICGYAFKLMSVNSGIKLEKILKKVGHTL-------LVQILSVVV 450
            :.|||:.|||||..|:.|::.:.     .:|:.....:.::  .:||.|       ::||::.|:
  Fly   385 ISYTESNGVILNYSVAGVALVLI-----FLSIWRTSSISRV--SIGHVLCWFILIFVLQIIAFVL 442

  Fly   451 GAILPVLLGLFMDAVHLPLSWFSNSWLILGLYFTTFFFGLAIVPALYFHWTKRDKLPIGQRVQLL 515
            |..||:::....|...|.:::||...|::|||......||::...:|....:.:|:...|.:||:
  Fly   443 GLGLPIVVAYVFDKYGLSITYFSTPVLLIGLYICPSLLGLSLPSYIYLKLQRSEKVGFAQHLQLV 507

  Fly   516 LHCHCLLLSVLTLIFTICGIRSVFVLMLSCLFYTVGLIINIATKLHTKDVAWVIPHIVCTVPPFV 580
            ||.|..:|::|.:..|:.|:||.:|...:.:||.:.|.:|:.|.||.:..:|.....:..|.||:
  Fly   508 LHGHAAVLAILDIGLTVYGLRSAYVPTWTLIFYVIPLAVNLLTTLHDRGFSWTGVLKIFQVVPFL 572

  Fly   581 FFAYFSHGFFTTFIPMFGRFGENLNPDLAVAVFSVAVGFLCCGFIIPVLQLFNKSKTIICGLMGI 645
            :.:|..:.|..|.|||.||||...||||.::........|..||:||::.:|.:...|:..|:.|
  Fly   573 YNSYLIYCFVVTLIPMMGRFGRATNPDLIISALCALGTILALGFVIPLVNMFRRPSLILLTLLAI 637

  Fly   646 T-LLCFIIAMTPIGFPYRPETNVQRFAVLHTKRTFHDAQNKVRRQESGYFIMPQDRR-TYTVKNA 708
            : :..:..:.|.|||||||:|||||...||.:|.|::....|.:.:|||....|||| ...:|.:
  Fly   638 SAVTIYTASSTQIGFPYRPKTNVQRLPYLHVRRIFYEYDGTVVKNDSGYLFNFQDRRGPAPLKLS 702

  Fly   709 VINMTLAQRIGSDCDKEINCGLPLYNQRWHKTRKNSLWIPASEPVLGENVPTVLLLSKNTVSPTK 773
            .:|.|....|.:|||..:.||.|||:.||.|.|...:|:|..|.::....|.:.||||..:....
  Fly   703 KLNTTGLVSIAADCDTVMMCGFPLYDHRWVKNRLQIMWLPREEEIITPYEPKLELLSKTELGNNT 767

  Fly   774 IRYEMQLSGPNHMALFIQPLNGAKMMDWSFHQAPLRLSF---EPPYFIYFSWGVNGDPLKFWLEL 835
            :|...|.:..:|.::|||||....:.:||     |..|:   :....:|||:|.|...|.|:::.
  Fly   768 LRMNFQSATTDHASVFIQPLEDVIISNWS-----LPTSYIGQQDTSHMYFSYGKNNTALTFFIDF 827

  Fly   836 EKPNGNWNSSTLELGLGGHWNHHK-ELITPDFKKFLDSFPHYVDATPWPASFESRIF 891
            .|.:.::.....::||..|:..:| :.|:.:|.|.:.||...||   ||||::..||
  Fly   828 YKLDADFAVPLCQIGLAVHFIGNKGDAISQEFAKKIPSFAAAVD---WPASYQRYIF 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11961	NP_001246418.1	M28_Fxna_like	91..395	CDD:193497	174/306 (57%)
CG10073	NP_001261090.1	M28_Fxna_like	80..387	CDD:193497	174/306 (57%)
CG10073	NP_001261090.1	NrfD	398..638	CDD:304401	70/246 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446900
Domainoid	1	1.000	161	1.000	Domainoid score	I1255
eggNOG	1	0.900	-	-		E1_COG2234
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	359	1.000	Inparanoid score	I1290
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14040at33392
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm25001
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	P	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X435
	12	11.800