DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11961 and CG13160

DIOPT Version :9

Sequence 1:	NP_001246418.1	Gene:	CG11961 / 37221	FlyBaseID:	FBgn0034436	Length:	891	Species:	Drosophila melanogaster
Sequence 2:	NP_001260918.1	Gene:	CG13160 / 36343	FlyBaseID:	FBgn0033720	Length:	875	Species:	Drosophila melanogaster

Alignment Length:	878	Identity:	354/878 - (40%)
Similarity:	531/878 - (60%)	Gaps:	39/878 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 NGCERAFVQGNKIK-------WFWAPAFFGFWLLLYVTISIPACHRLPRPLTIQDEETHPDQFIA 96
            :|.|...::.::.|       |::||.:..||:.|:..:..|....||..:.|.:|...|.||:|
  Fly    12 SGSENLIIEVDEDKIRCKQYSWYFAPIYLLFWVGLFFAVIYPLFQALPTGIKISEEADKPGQFVA 76

  Fly    97 ERAEKNLRELVSLGPRVVGSRQNEMAALKMLSQKMQKIRSGTANDI---EVDVQVASGSYVHWSM 158
            |||::.|.::..|||||||...||:..:.:|..:::|:|....:|:   ||:||.|||||:...:
  Fly    77 ERAQEILLQISRLGPRVVGDVDNEVTVVNLLLAEIEKVRQVLRDDVYEMEVEVQRASGSYLIKGL 141

  Fly   159 VNMYQSIQNIVVKISPKNTNSTTYLLVNSHYDSVPAGPGAGDDGSMVATMMEVLRVLAKSDKPLK 223
            .|.||.:||::|::|.|::|||:|||||||||:.|..||||||.:||..|:||||::|.|..|..
  Fly   142 TNHYQGVQNVIVRLSTKSSNSTSYLLVNSHYDTKPGSPGAGDDAAMVVVMLEVLRLVAVSGDPFL 206

  Fly   224 NPVVFLFNGAEENPLQASHAFITQHKWAKYCKALINLDSCGNGGREILFQSGPNHPWLMKNYRRA 288
            :|::||||||||.|:|.||.|||||:||..||||:||||.|.|||::|||.||||||||::||.:
  Fly   207 HPIIFLFNGAEEQPMQGSHGFITQHRWAANCKALLNLDSAGAGGRDLLFQGGPNHPWLMEHYRNS 271

  Fly   289 IKHPYASTMGEELFQHNFIPSDTDFRIFRDHGSVPGLDMAYTYNGFVYHTRHDKAEIFPRGSFQH 353
            ..||:|:|..||:|:...||||||||||||.|.|||||||..||||||||:.|:..:....|.|:
  Fly   272 APHPFATTTAEEMFEAGIIPSDTDFRIFRDFGVVPGLDMAGVYNGFVYHTKFDRYAVISLDSLQN 336

  Fly   354 TGDNLLALVRQIANSPEIENSAKYAKGHTIYFDVMGWFLVFYTETEGVILNVIVSLVSIGICGYA 418
            :||||||||..|:|:.|:.::..:|.||.::||.:|.|.|.|.|:..:.||:..|..:|.:...:
  Fly   337 SGDNLLALVWSISNAEEMYDTEAHAAGHAVFFDFIGLFFVHYQESTSLALNLFFSFGAILLVCIS 401

  Fly   419 FKLMSVNSGIKLEKILKKVGHTLLVQILSVVVGAILPVLLGLFMDAVHLPLSWFSNSWLILGLYF 483
            ...||..:|..:.......|...|:.:...::....|:|:..|.|..:..|::||||||::|||.
  Fly   402 LWRMSRVTGQTMGTYAGVFGLLFLLALAGALLAVAFPLLMATFYDWGNRTLTYFSNSWLVIGLYI 466

  Fly   484 TTFFFGLAIVPALYFHWTKRDKLPIGQRVQLLLHCHCLLLSVLTLIFTICGIRSVFVLMLSCLFY 548
            .....||.:...||...||.:|:|....:.::.|.:|:||::|.|..|....||.::.::|.:||
  Fly   467 CPSVIGLVLPMTLYLTHTKCNKIPHTYYLHIVGHANCVLLAILCLGATALKYRSAYLFLISLIFY 531

  Fly   549 TVGLIINIATKLHTKDVAWVIPHIVCTVPPFVFFAYFSHGFFTTFIPMFGRFGENLNPDLAVAVF 613
            ...||||:.|:||.:...|.:..||..:.||::.||..|.|....|||.||||.:.|||:.:...
  Fly   532 VAALIINLLTRLHCRGYLWSLVLIVFQIIPFIYHAYLFHMFILILIPMTGRFGVSTNPDILIGAL 596

  Fly   614 SVAVGFLCCGFIIPVLQLFNKSKTIICGLMGITLLCFI---IAMTPIGFPYRPETNVQRFAVLHT 675
            ......|...|..|::.:|.:..   |.|.|:.|:.||   ||::.:||||||:|||.|...:..
  Fly   597 CGFGTILALSFAAPLINVFRRPN---CMLGGLALVMFIFCMIAVSDVGFPYRPKTNVMRADFMQV 658

  Fly   676 KRTFHDAQNKVRRQESGYFIMPQDRRTYTVKNAVINMTLAQRIGSDCDKEINCGLPLYNQRWHKT 740
            .|.|.:....:..::|||:....||.........:|:|...|:|.|||.|:.||:|.|  |:...
  Fly   659 HRKFFEYNGSISHEDSGYYFHLGDRNKEAPLRDHMNLTNLVRLGEDCDSELMCGIPCY--RYCSA 721

  Fly   741 RKNSLWIPASEPVLGENVPTVL-LLSKNTVS-PTKIRYEMQLSGPNHMALFIQPLNGAKMMDWSF 803
            |:::||:...||| ....|||| .|||..:| ..::|||.:|:||.:|.||.:||:|.|::.|:|
  Fly   722 REHALWLAREEPV-ELPYPTVLEFLSKTVLSGGYQVRYEFRLTGPPNMGLFFKPLDGVKLLRWTF 785

  Fly   804 HQAPLRL----SFEPPYFIYFSWGVNGDPLKFWLELEKPNGNWNSSTLELGLGGHWNHHKELITP 864
              ||..|    ::.||..:..::|::..|::|::||.|.:||:|....|:|:.||:      ::|
  Fly   786 --APAMLDNPATYRPPLEVMLTYGIDNTPIEFFVELSKDDGNFNEPVFEMGVSGHY------VSP 842

  Fly   865 DFKK------FLDSFPHYVDATPWPASFESRIF 891
            ..|:      ||.:.|.:..:..||:|:|..||
  Fly   843 HDKRDALSLEFLATLPDFAFSMEWPSSYERHIF 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11961	NP_001246418.1	M28_Fxna_like	91..395	CDD:193497	169/306 (55%)
CG13160	NP_001260918.1	M28_Fxna_like	71..378	CDD:193497	169/306 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446901
Domainoid	1	1.000	161	1.000	Domainoid score	I1255
eggNOG	1	0.900	-	-		E1_COG2234
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	212	1.000	Inparanoid score	I1244
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14040at33392
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm25001
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	P	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X435
	12	11.800