DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11961 and SPCC1259.02c

DIOPT Version :9

Sequence 1:	NP_001246418.1	Gene:	CG11961 / 37221	FlyBaseID:	FBgn0034436	Length:	891	Species:	Drosophila melanogaster
Sequence 2:	NP_001342785.1	Gene:	SPCC1259.02c / 2539040	PomBaseID:	SPCC1259.02c	Length:	822	Species:	Schizosaccharomyces pombe

Alignment Length:	836	Identity:	214/836 - (25%)
Similarity:	353/836 - (42%)	Gaps:	182/836 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 HRLPRPLTIQDEETHPDQFIAERAEKNLRELV-SLGPRVVGSRQNEMAALKMLSQKM---QKIRS 136
            :.|..||....:.....||....|.|::..|. .:|.|::|:.:.|.|...::::.:   ::::.
pombe    37 NHLDEPLVDPYDANGNPQFSEANALKHVIHLSDDIGYRILGTIEQERAREYIMNEVLALQKQLQD 101

  Fly   137 GTANDI-EVDVQVASG------SYVHWSMVNMYQSIQNIVVKISPKNTNST-----TYLLVNSHY 189
            |...|| :::|.:.||      .:::..::..||:::||||::|    |.|     ..:|:|:|.
pombe   102 GPNADIHQMEVSLESGDGAHRFDFMNKYVIKKYQNLKNIVVRLS----NGTEACKEEAVLINAHV 162

  Fly   190 DSVPAGPGAGDDGSMVATMMEVLRVLAKSDKPLKNPVVFLFNGAEENPLQASHAFITQHKWAKYC 254
            ||....|||.||...||.::|.:|:......||.:.:|||||.|||:...|||.||||.......
pombe   163 DSTLPSPGATDDALAVAILLEAIRIFISRPVPLTHSIVFLFNDAEESLQDASHMFITQSPLRDTI 227

  Fly   255 KALINLDSCGNGGREILFQSGPNHPWLMKNYRRAIKHPYASTMGEELFQHNFIPSDTDFRIFRDH 319
            |.::||::||..|.|||||:..|.  ::|.|.. :.||:.:.:.:::|:...|.||||||.|..:
pombe   228 KCVVNLEACGTTGSEILFQATSNE--MIKAYSH-VPHPFGTVLADDVFRTGLILSDTDFRQFVQY 289

  Fly   320 GSVPGLDMAYTYNGFVYHTRHDKAEIFPRGSFQHTGDNLLALVRQIANSPEIENSAKYAKGHTIY 384
            |::.|||||...|.::|||:.|.|.....|:.|:.|:|:||::..:. |||.:.:...:.| |:|
pombe   290 GNLTGLDMAVVKNSYLYHTKKDLAPYISPGTPQNFGENILAILTYLV-SPEADLNNMKSSG-TVY 352

  Fly   385 FDVMGWFLVFYTETEGVILNVIVSLVSIGICGYAFKLMSVNSGIKLEKILKKVGHTLLVQILSV- 448
            |.|.......|::....|||.:|     |..|....|........:         .|:.|::|:
pombe   353 FSVFNSLFFMYSKLTSKILNTLV-----GGLGILLTLRGSEGSFTV---------ALIAQVISIA 403

  Fly   449 ---VVGAILPVLLGLFMDAVHLPLSWFSNSWLILGLYFTTFFFGLAIVPALYFHWTKRDKLPIGQ 510
               |:..|...:||..:|.   .:|||.|.:..|.:|....|..|....:|:    ||.:
pombe   404 GIFVIPNIWAYILGNVLDC---GMSWFRNEYWPLFIYLPAIFASLFFTESLF----KRSE----- 456

  Fly   511 RVQLLLHCHCLLLSVLTLI-------FTICGIRSVFVLMLSCLFYTVGLIINIATKLHTKDVAWV 568
              .|.|.....:.|:||.|       |||.....||.|.|:             .|:..|.
pombe   457 --HLALRATIFIFSLLTFIPLPSAYLFTIIDFFMVFALFLN-------------DKILAKP---- 502

  Fly   569 IPHIVCTVPPFVFF----AYFSHGF------FTTFIPMFGRFGENLNPDLAVAVFSVAVGFLCCG 623
                 .||.|..:|    ...:.||      ...|:|:.||.|.:...|..||...|      ||
pombe   503 -----GTVHPLTYFIGSIGAMTVGFESAINLLEIFVPLTGRIGTDKVADNVVATVCV------CG 556

  Fly   624 FII------PVLQLFNKSKTIICGLMGITLLCFIIAMTPIGFPYRPETNVQRFAVLHTKRTFHDA 682
            |.|      |.:|.|   ::..|..:|:....|::..:..              :|..:.|::|:
pombe   557 FNIYFPLMSPWIQRF---RSRCCFRLGLLFSIFVVGFSSF--------------ILAKQDTYYDS 604

  Fly   683 QNKVRRQESGYFIMPQDRRTYTVKNAVINMTLA------QRIGSDC------DKEINCGLPLYNQ 735
            .:..|       |..|.....|.....:::..|      .::.||.      :..:...:..:|.
pombe   605 LHPRR-------IFVQRMENITSNEVSLHIASADSAPGFDKLSSDLSSLLTDEPVVKTEMDDWNS 662

  Fly   736 RWHKTRK-----NSLWIPASEPVLGENVPTVLLLSK----NTVSPTKIRYEMQLSGPNHMALFIQ 791
            .|.....     .|..||.::.|....:|::...:|    |.|:.| :..|       |..|...
pombe   663 DWDTVYPFSQFLGSYRIPLNDTVDVTTLPSIKFSNKVVKDNVVNVT-VTVE-------HPGLIWT 719

  Fly   792 PLN-GAKMMDWSFHQAPLRL----------------SFEPPYF---IYFSW-GVNG 826
            .:: .|.::.||..:.|..:                ||...|.   |||.: ||:|
pombe   720 VVSFDADVLSWSLPEVPSTVRRHHVREVSAYGLDSYSFNMSYLEAPIYFDFVGVDG 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11961	NP_001246418.1	M28_Fxna_like	91..395	CDD:193497	107/319 (34%)
SPCC1259.02c	NP_001342785.1	M28_Fxna_like	52..363	CDD:193497	107/319 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	161	1.000	Domainoid score	I973
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	233	1.000	Inparanoid score	I847
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm47049
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	O	PTHR12147
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1738
SonicParanoid	1	1.000	-	-		X435
TreeFam	1	0.960	-	-
	13	12.850