DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11961 and CG30047

DIOPT Version :9

Sequence 1:	NP_001246418.1	Gene:	CG11961 / 37221	FlyBaseID:	FBgn0034436	Length:	891	Species:	Drosophila melanogaster
Sequence 2:	NP_725141.1	Gene:	CG30047 / 246414	FlyBaseID:	FBgn0050047	Length:	879	Species:	Drosophila melanogaster

Alignment Length:	856	Identity:	352/856 - (41%)
Similarity:	542/856 - (63%)	Gaps:	19/856 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 NKIKWFWAPAFFGFWLLLYVTISIPACHRLPRPLTIQDEETHPDQFIAERAEKNLRELVSLGPRV 113
            :::.|::||:|...|:.|:..:..|..||||..:.|..|.:.|.||:||||::.|.:...:||:|
  Fly    30 HRLPWYYAPSFLLLWVALFYAVVYPLYHRLPDSVLISHESSKPGQFVAERAQRLLYKYDKIGPKV 94

  Fly   114 VGSRQNEMAALKMLSQKMQKIRSGTAND---IEVDVQVASGSYVHWSMVNMYQSIQNIVVKISPK 175
            |||..||:..:..|.::::.||:...:|   :::|||..||:|:||.||||||.:.|:|||||.:
  Fly    95 VGSVANEVTTVAFLEEEVENIRAAMRSDLYELQLDVQHPSGAYMHWQMVNMYQGVTNVVVKISSR 159

  Fly   176 NTNSTTYLLVNSHYDSVPAGPGAGDDGSMVATMMEVLRVLAKSDKPLKNPVVFLFNGAEENPLQA 240
            ::||::|||||||:||.|:.||:||||:||..|:||||.:|.||.|.::|:||||||||||||:|
  Fly   160 SSNSSSYLLVNSHFDSKPSSPGSGDDGTMVVVMLEVLRQVAISDTPFEHPIVFLFNGAEENPLEA 224

  Fly   241 SHAFITQHKWAKYCKALINLDSCGNGGREILFQSGPNHPWLMKNYRRAIKHPYASTMGEELFQHN 305
            ||.||||||||..|||||||:..|:|||::|||||||:|||:|.|.:..|||:|:||.||:||..
  Fly   225 SHGFITQHKWAGNCKALINLEVAGSGGRDLLFQSGPNNPWLIKYYYQNAKHPFATTMAEEIFQSG 289

  Fly   306 FIPSDTDFRIFRDHGSVPGLDMAYTYNGFVYHTRHDKAEIFPRGSFQHTGDNLLALVRQIANSPE 370
            .:|||||||||||:|.:||||||...||:||||..|..:..|..|.|.:|||.|:|||..|::||
  Fly   290 ILPSDTDFRIFRDYGQLPGLDMAQISNGYVYHTIFDNVQAVPIDSLQSSGDNALSLVRAFADAPE 354

  Fly   371 IENSAKYAKGHTIYFDVMGWFLVFYTETEGVILNVIVSLVSIGICGYAFKLMSVNSGIKLEKILK 435
            ::|...:::||.::||.:|.|.|:|||..|::||..:::.|:.:...:...|...|.:.:.::..
  Fly   355 MQNPEDHSEGHAVFFDYLGLFFVYYTENTGIVLNCCIAVASLVLVVCSLLRMGRESDVSIGRVSI 419

  Fly   436 KVGHTLLVQILSVVVGAILPVLLGLFMDAVHLPLSWFSNSWLILGLYFTTFFFGLAIVPALYFHW 500
            .....|::.:|.:::...||:|:.:..||....:::|||:||::||:......|..:...||:..
  Fly   420 WFAIILVLHVLGMILSLGLPLLMAVLFDAGDRSMTYFSNNWLVIGLFIVPAIIGQILPLTLYYTL 484

  Fly   501 TKRDKLPIGQRVQLLLHCHCLLLSVLTLIFTICGIRSVFVLMLSCLFYTVGLIINIATKLHTKDV 565
            ...|::.....:.:.||.||:|||::.:|.|...:|:.::.|:|.|||...|:||:.:.||.:..
  Fly   485 KPNDEISHPNHIHMSLHAHCVLLSLIAIILTAISLRTPYLCMMSLLFYGGALLINLLSTLHDRGY 549

  Fly   566 AWVIPHIVCTVPPFVFFAYFSHGFFTTFIPMFGRFGENLNPDLAVAVFSVAVGFLCCGFIIPVLQ 630
            .||:...|..:.||::|.|..:.|...|.||.||||...||||.:|:......|...||:.|::.
  Fly   550 YWVVLVQVLQLVPFLYFCYLFYTFLLVFFPMLGRFGHGTNPDLLIALICAVGTFFALGFVAPLIN 614

  Fly   631 LFNKSKTIICGLMGITLLCFIIAMTPIGFPYRPETNVQRFAVLHTKRTFHDAQNKVRRQESGYFI 695
            :|...|..:.||..:|.:..:||::.:|||||.:|:|.|...||.:|.|::....|...:|||:.
  Fly   615 IFRWPKLALLGLGVVTFIFSMIAVSEVGFPYRAKTSVMRIHFLHVRRIFYEYDGSVSLSDSGYYF 679

  Fly   696 MPQDRRT-YTVKNAVINMTLAQRIGSDCDKEINCGLPLYNQRWHKTRKNSLWIPASEPVLGENVP 759
            ..||||. |.::|..:|:|......|:|||.:.||:|.:|.||.|||..|.|:|..:.|......
  Fly   680 DFQDRRLYYPLENTSVNLTGLASTSSECDKYLMCGVPCFNHRWCKTRAKSHWLPREQEVAIPGAT 744

  Fly   760 TVLLLSKNTVSPTKI-RYEMQLSGPNHMALFIQPLNGAKMMDWSFHQAPLRL--SFEPPYFIYFS 821
            ::.||||..:...|: |:|.::|||.||:|:||||:|.::.||||.:..|..  ::.|||.|:|:
  Fly   745 SLKLLSKAVLDSGKVARFEFEISGPPHMSLYIQPLDGVEVEDWSFIRNMLDEPDTYSPPYQIFFA 809

  Fly   822 WGVNGDPLKFWLELEKPNGNWNSSTLELGLGGHWNHHKELITPDFK------KFLDSFPHYVDAT 880
            :|.:..||||.::..|.:|::::.|.:||...      ..::.|:.      ||:..||.:....
  Fly   810 YGADNTPLKFHIDFAKSSGDFSTPTFQLGFAA------SFVSYDYDRDAAGLKFISDFPDFAHVM 868

  Fly   881 PWPASFESRIF 891
            .||..:|..||
  Fly   869 EWPTLYERYIF 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11961	NP_001246418.1	M28_Fxna_like	91..395	CDD:193497	172/306 (56%)
CG30047	NP_725141.1	M28_Fxna_like	72..379	CDD:193497	172/306 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446903
Domainoid	1	1.000	161	1.000	Domainoid score	I1255
eggNOG	1	0.900	-	-		E1_COG2234
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	212	1.000	Inparanoid score	I1244
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14040at33392
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm25001
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	P	PTHR12147
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1738
SonicParanoid	1	1.000	-	-		X435
	13	12.830