Protein Alignment EndoB and Sh3glb2

DIOPT Version :10

• Sequence 1: NP_611410.1
• Gene: EndoB / 37218
• FlyBaseID: FBgn0034433
• Length: 390
• Species: Drosophila melanogaster
• Sequence 2: NP_001333735.1
• Gene: Sh3glb2 / 227700
• MGIID: 2385131
• Length: 404
• Species: Mus musculus
• Alignment Length: 411
• Identity: 170/411 - (41%)
• Similarity: 245/411 - (59%)
• Gaps: 44/411 - (10%)

  Fly     7 NFNVKNLVKEAGSTISRVVQLTEEKLGTTERTEYDLHFQNLAERADVTKTWTEKIVRDTESVLIP 71
            :||:|.|..:||...:|.||.||||.|..|:||.|.||:||..|||.||.|||:|:|.||.:|.|
Mouse     2 DFNMKKLASDAGIFFTRAVQFTEEKFGQAEKTELDAHFENLLARADSTKNWTERILRQTEVLLQP 66

  Fly    72 NPQNRVEDFIFEKIEKSKPKRLSNLEHLALDMIEAGGDFGQDLPYGQALIKVGQAEQKLGQCEHD 136
            ||..|||:|::||:::..|.|::|.|.||..|.||..:.|...|||:.||||.:||::||..|.|
Mouse    67 NPSARVEEFLYEKLDRKVPSRVTNGELLAQYMAEAASELGPSTPYGKTLIKVSEAEKRLGAAERD 131

  Fly   137 FIATSGICFTQPLRKFLDGEMKTIGKERGILETKRLDLDACKNRVKKARSMLGQQSKDG------ 195
            ||.|:.:.|..|||.||:|:.|||.|||.:|:.:||||||||.|:|||::...:.:.:|
Mouse   132 FIHTASLSFLTPLRNFLEGDWKTISKERRLLQNRRLDLDACKARLKKAKAAEAKATCEGDTVPDF 196

  Fly   196 ---------ISPEA------VLEQAERDLRVAQAEFDRQAEITKLLLDGISTSQASHLRHLHAFI 245
                     :|..|      .:::||::|||||.|||||||:|:|||:|||::..:|||.||.|:
Mouse   197 QETRPRNYILSASASALWNDEVDKAEQELRVAQTEFDRQAEVTRLLLEGISSTHVNHLRCLHEFV 261

  Fly   246 QTQVRYYKQCGDVMEQLQRELANLGG---PTPYI--------PLDVNE---ASASKSNISSGAAA 296
            ::|..||.||...|..||::|.:..|   |..::        ||....   .:|:...:.:||..
Mouse   262 KSQTTYYAQCYRHMLDLQKQLGSSQGAIFPGTFVGTTEPASPPLSSTSPTTTAATMPVVPTGAVL 326

  Fly   297 RGPGNNHSANMAATGHKPNQPMHVSTDQMQRARVLCSYDAKDHTELNLSANEVIFVTECSPVNED 361
            ..|      ..||...:...|....|   ::||||..|:|.|.:||.|.|:|:|.|.....::.|
Mouse   327 APP------EEAALCLEEVAPPASGT---RKARVLYDYEAADSSELALLADELITVYSLPGMDPD 382

  Fly   362 YMYGKQGLLKGLVPRAFVEML 382
            ::.|::|..||.||..::|:|
Mouse   383 WLIGERGNKKGKVPVTYLELL 403

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EndoB	NP_611410.1	BAR_Endophilin_B	26..266	CDD:153278	126/260 (48%)
		SH3_Endophilin_B	327..378	CDD:212736	21/50 (42%)
Sh3glb2	NP_001333735.1	Membrane-binding amphipathic helix. /evidence=ECO:0000250	1..27		12/24 (50%)
		BAR_Endophilin_B2	21..282	CDD:153301	126/260 (48%)
		SH3_Endophilin_B2	348..402	CDD:212877	21/53 (40%)