Protein Alignment EndoB and Sh3gl2

DIOPT Version :10

• Sequence 1: NP_611410.1
• Gene: EndoB / 37218
• FlyBaseID: FBgn0034433
• Length: 390
• Species: Drosophila melanogaster
• Sequence 2: NP_446387.1
• Gene: Sh3gl2 / 116743
• RGDID: 620276
• Length: 352
• Species: Rattus norvegicus
• Alignment Length: 394
• Identity: 92/394 - (23%)
• Similarity: 157/394 - (39%)
• Gaps: 68/394 - (17%)

  Fly     9 NVKNLVKEAGSTISRVVQLTEEKLGTTERTEYDLHFQNLAERADVTKTWTEKIVRDTESVLIPNP 73
            :|..|.|:    ..:..|...||:|..|.|:.|..|:.:..:.|||.....:|:..|...|.|||
  Rat     2 SVAGLKKQ----FHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNP 62

  Fly    74 QNRVEDFIFEKIEK----SKPKRLSNLEHLALD-MIEAGGDFGQDLPYGQALIKVGQAEQKLGQC 133
            .:|.:..:...:.|    .|.......|.|..: |::.|.:.|.|..:|.||.:||:|.::|.:.
  Rat    63 ASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEV 127

  Fly   134 EHDFIATSGICFTQPLRKFLDGEMKTIGKERGILETKRLDLDACKNRVKKARSMLGQQSKDGISP 198
            :..........|..||:...|.:::.|......||.:|||.|..|.|..|.
  Rat   128 KDSLDMEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKI-------------- 178

  Fly   199 EAVLEQAERDLRVAQAEFDRQAEITKLLLDGISTSQASHLRHLHAFIQTQVRYYKQCGDVMEQL- 262
                  .:.:||.|..:||...||.:..:..:.......:..|.|.:|.|:.|:||...:::|:
  Rat   179 ------PDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVT 237

  Fly   263 --------------QRELANLGGPTPYIPLDVNEASASKSNISSGAAARGPGNNHSANMAATGHK 313
                          :||..    |.|.:.|:.               |.|.|...:..::.||
  Rat   238 VRLEERIRQASSQPRREYQ----PKPRMSLEF---------------ATGDGTQPNGGLSHTG-- 281

  Fly   314 PNQPMHVSTDQMQRARVLCSYDAKDHTELNLSANEVIFVTECSPVNEDYMYGKQGLLKGLVPRAF 378
            ..:|..|..|| ...|.|..::.::..||.....::|.:|  :.::|::..|......|..|..:
  Rat   282 TPKPAGVQMDQ-PCCRALYDFEPENEGELGFKEGDIITLT--NQIDENWYEGMLHGQSGFFPINY 343

  Fly   379 VEML 382
            ||:|
  Rat   344 VEIL 347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EndoB	NP_611410.1	BAR_Endophilin_B	26..266	CDD:153278	63/259 (24%)
		SH3_Endophilin_B	327..378	CDD:212736	10/50 (20%)
Sh3gl2	NP_446387.1	Binds and tubulates liposomes	1..125		35/126 (28%)
		Membrane-binding amphipathic helix	1..21		5/22 (23%)
		BAR_Endophilin_A1	25..247	CDD:153297	58/241 (24%)
		Required for dimerization upon membrane association	60..87		6/26 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	246..289		11/63 (17%)
		SH3_Endophilin_A	293..347	CDD:212737	12/55 (22%)