Protein Alignment wbl and Erp29

DIOPT Version :10

• Sequence 1: NP_725867.1
• Gene: wbl / 37206
• FlyBaseID: FBgn0004003
• Length: 257
• Species: Drosophila melanogaster
• Sequence 2: NP_080405.1
• Gene: Erp29 / 67397
• MGIID: 1914647
• Length: 262
• Species: Mus musculus
• Alignment Length: 276
• Identity: 81/276 - (29%)
• Similarity: 137/276 - (49%)
• Gaps: 48/276 - (17%)

  Fly     1 MMHILVTLLLV-------AIHSIPTTWAVTCTGCVDLDELSFEKTVERFPYSVVKFDIAYPYGEK 58
            ::.:|:.|||:       .:|:         .|.:.||.::|.|.:.:..:.:||||..||||||
Mouse    16 LLSVLLGLLLLFAPHGGSGLHT---------KGALPLDTVTFYKVIPKSKFVLVKFDTQYPYGEK 71

  Fly    59 HEAFTAFSKSAHKATKDLLIATVGVKDYGELENKALGDRYKVDDKNFPSIFLFKGNADEYVQLPS 123
            .:.|...:::: .::::||:|.||:.|||:..|..|.::||:|.:::|..:||:
Mouse    72 QDEFKRLAENS-ASSEELLVAEVGISDYGDKLNMELSEKYKLDKESYPVFYLFR----------- 124

  Fly   124 HVDVTLDNLKAFVSA-----------NTPLYIGRDGCIKEFNEVLKNYANIPDAEQLKLIEKLQA 177
              |..|:|...:..|           ...:|:|..||:..::.:...:......|..:.|.| |.
Mouse   125 --DGDLENPVLYNGAVKVGAIQRWLKGQGVYLGMPGCLPAYDALAGEFIKASSIEARQAILK-QG 186

  Fly   178 KQEQLTDPEQQQN-ARAYLIYMRKIHEVGYDFLEEETKRLLRLKAGKVTEAKKEELLRKLNILEV 241
            :...|:..|.::. |..||..|.||.:.|.||...|..|:.:|...|::::|||||.:.||||..
Mouse   187 QDGLLSVKETEKKWASQYLKIMGKILDQGEDFPASEMARIGKLIENKMSDSKKEELQKSLNILTA 251

  Fly   242 FRVHKVTKTAPEKEEL 257
            ||     |...|||||
Mouse   252 FR-----KKEAEKEEL 262

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wbl	NP_725867.1	ERp29_N	22..147	CDD:400320	38/135 (28%)
		ERp29	148..242	CDD:462253	30/94 (32%)
Erp29	NP_080405.1	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold	35..157	CDD:469754	39/144 (27%)
		ERp29	158..252	CDD:462253	30/94 (32%)
		Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138	259..262		2/2 (100%)