DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wbl and Erp29

DIOPT Version :9

Sequence 1:	NP_001286609.1	Gene:	wbl / 37206	FlyBaseID:	FBgn0004003	Length:	257	Species:	Drosophila melanogaster
Sequence 2:	NP_080405.1	Gene:	Erp29 / 67397	MGIID:	1914647	Length:	262	Species:	Mus musculus

Alignment Length:	276	Identity:	81/276 - (29%)
Similarity:	137/276 - (49%)	Gaps:	48/276 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MMHILVTLLLV-------AIHSIPTTWAVTCTGCVDLDELSFEKTVERFPYSVVKFDIAYPYGEK 58
            ::.:|:.|||:       .:|:         .|.:.||.::|.|.:.:..:.:||||..||||||
Mouse    16 LLSVLLGLLLLFAPHGGSGLHT---------KGALPLDTVTFYKVIPKSKFVLVKFDTQYPYGEK 71

  Fly    59 HEAFTAFSKSAHKATKDLLIATVGVKDYGELENKALGDRYKVDDKNFPSIFLFKGNADEYVQLPS 123
            .:.|...:::: .::::||:|.||:.|||:..|..|.::||:|.:::|..:||:
Mouse    72 QDEFKRLAENS-ASSEELLVAEVGISDYGDKLNMELSEKYKLDKESYPVFYLFR----------- 124

  Fly   124 HVDVTLDNLKAFVSA-----------NTPLYIGRDGCIKEFNEVLKNYANIPDAEQLKLIEKLQA 177
              |..|:|...:..|           ...:|:|..||:..::.:...:......|..:.|.| |.
Mouse   125 --DGDLENPVLYNGAVKVGAIQRWLKGQGVYLGMPGCLPAYDALAGEFIKASSIEARQAILK-QG 186

  Fly   178 KQEQLTDPEQQQN-ARAYLIYMRKIHEVGYDFLEEETKRLLRLKAGKVTEAKKEELLRKLNILEV 241
            :...|:..|.::. |..||..|.||.:.|.||...|..|:.:|...|::::|||||.:.||||..
Mouse   187 QDGLLSVKETEKKWASQYLKIMGKILDQGEDFPASEMARIGKLIENKMSDSKKEELQKSLNILTA 251

  Fly   242 FRVHKVTKTAPEKEEL 257
            ||     |...|||||
Mouse   252 FR-----KKEAEKEEL 262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wbl	NP_001286609.1	ERp29_N	22..147	CDD:254509	38/135 (28%)
wbl	NP_001286609.1	ERp29	149..242	CDD:285048	29/93 (31%)
Erp29	NP_080405.1	Thioredoxin_like	35..157	CDD:294274	39/144 (27%)
		ERp29	159..252	CDD:285048	29/93 (31%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	259..262		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831512
Domainoid	1	1.000	76	1.000	Domainoid score	I8958
eggNOG	1	0.900	-	-		E1_28K2V
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4963
Inparanoid	1	1.050	116	1.000	Inparanoid score	I4807
Isobase	1	0.950	-	0	Normalized mean entropy	S7243
OMA	1	1.010	-	-		QHG59606
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0012441
OrthoInspector	1	1.000	-	-		oto94225
orthoMCL	1	0.900	-	-		OOG6_109017
Panther	1	1.100	-	-	LDO	PTHR12211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4822
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.740