Protein Alignment botv and Extl3

DIOPT Version :10

• Sequence 1: NP_523790.1
• Gene: botv / 37198
• FlyBaseID: FBgn0027535
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: NP_064482.1
• Gene: Extl3 / 56819
• RGDID: 62065
• Length: 919
• Species: Rattus norvegicus
• Alignment Length: 986
• Identity: 474/986 - (48%)
• Similarity: 630/986 - (63%)
• Gaps: 110/986 - (11%)

  Fly    20 GSGGGNEACAPNSSSAQIRHSMGFRTSWMRQFRRYKLPMVLLMLLFLVSCLAYRILSVEQDAPPL 84
            |.|.|.:.|       .:|.|...|.:|        |...|.::|.....:|:..|:...:|.
  Rat    11 GVGNGGQTC-------MLRWSNRIRLTW--------LSFTLFIILVFFPLIAHYYLTTLDEAD-- 58

  Fly    85 DLHRSSPLLDAYEDFSAMRAGDLKMRIE---EMVRIKSTVSVELRELESRRQKLQSDISQYNQKI 146
                     :|.:.....|||:....::   ::.||:.:||.||.:||::||:|.|:|::.|.||
  Rat    59 ---------EAGKRIFGPRAGNELCEVKHVLDLCRIRESVSEELLQLEAKRQELNSEIAKLNLKI 114

  Fly   147 EELKQELLREQTELERLKISVEQAQVAQREAVQRNTPDLALPRSLLPNT----LPRKSNPITGGM 207
            |..|:.:...:.:|.:||..:.|.:.:.:|.:.:|.|.|:||..|||..    ||...  :|.|
  Rat   115 EACKKSIENAKQDLLQLKNVISQTEHSYKELMAQNQPKLSLPIRLLPEKDDAGLPPPK--VTRG- 176

  Fly   208 AASCEMHNCFNHSRCSLTSGFPVYLYDPDEHSVQRKGYDIDGFLKTTLKQTLGYNAHIVKDPKHA 272
               |.:||||::|||.|||||||::||.|:.:.   |..:|..:|...:.|:..|.::.::...|
  Rat   177 ---CRLHNCFDYSRCPLTSGFPVFVYDSDQFAF---GSYLDPLVKQAFQATVRANVYVTENAAIA 235

  Fly   273 CIYLVLVGEALLEQDLLRNNRYAAQEAEHQQPSTPTLENDCPVDMEK-LYSLPYWGGDGRNHVLL 336
            |:|:|||||.                   |:|:  .|:   |.|:|| |:|||:|..||.|||::
  Rat   236 CLYVVLVGEI-------------------QEPA--VLQ---PADLEKQLHSLPHWRTDGHNHVII 276

  Fly   337 NLARRDLTSHRTNPLYRQNTMRAIVVQSAFEREQFRPGYDLIVPPILGPPGGDVWQECAEMVPAR 401
            ||:|:   |...|.||..:|.||:|.||.|...|:|.|:||:|.|::.......:.|....||.:
  Rat   277 NLSRK---SDTQNLLYNVSTGRAMVAQSTFYAAQYRAGFDLVVSPLVHAMSEPNFMEIPPQVPVK 338

  Fly   402 RKYLLTYQGE-LRPKQSSLNPLDAFILEHLAD--------------MAKGATQDQFVLQFQCVPA 451
            ||||.|:||| :...:|||....:|..|...|              ..:.:..||.:::|.|
  Rat   339 RKYLFTFQGEKIESLRSSLQEARSFEEEMEGDPPADYDDRIIATLKAVQDSKLDQVLVEFTC--- 400

  Fly   452 TEQQEGDSLP-DWTLCGSDSSRRQLLKDSTFSLILPPLNGRVS---STLMLARIYEALRSGAVPV 512
             :.|...||| :|.|||....|.:|||.|||:||:.|  |..|   |:....|::|||..|||||
  Rat   401 -KNQPKPSLPTEWALCGEREDRLELLKLSTFALIITP--GDPSLLISSGCATRLFEALEVGAVPV 462

  Fly   513 ILGADELRLPYAETVDWRRTALLLPKARITELHFLLRAVQDADLLLLRRQGRLIWERYLSSVQAT 577
            :|| ::::|||.:.:.|...||::||.|:||:|||||::.|:|||.:|||||.:||.|.|:..:.
  Rat   463 VLG-EQVQLPYHDMLQWNEAALVVPKPRVTEVHFLLRSLSDSDLLAMRRQGRFLWETYFSTADSI 526

  Fly   578 VDTVIASLRDRLGIPPRPVPSVIAQSVFNSTFIPLKSDPPVGLDTEPEES----LGPI--EPPYP 636
            .:||:|.:|.|:.||..|:...:|..      ||.:|....|.|....::    |||:  ||||.
  Rat   527 FNTVLAMIRTRIQIPAAPIREEVAAE------IPHRSGKAAGTDPNMADNGDLDLGPVETEPPYA 585

  Fly   637 SPAFRRNYTILRMQAKEAWNDWLDPFYLYPQLPFDPALPSEAKFMGSHTGFRPIGKGLGGAGKEF 701
            ||.:.||:|:.......:||....||:|:|..||||.|||||||:||.|||||||.|.||:||||
  Rat   586 SPKYLRNFTLTVTDCYRSWNSAPGPFHLFPHTPFDPVLPSEAKFLGSGTGFRPIGGGAGGSGKEF 650

  Fly   702 GESLGGNYPREQFTIVMLTYEREQVLMDSLGRLYGLPYLHKVVVVWNSPKPPLDDLRWPDIGVPV 766
            ..:||||..|||||:||||||||:|||:||.||.|||||:||||||||||.|.:||.|||||||:
  Rat   651 QAALGGNVQREQFTVVMLTYEREEVLMNSLERLNGLPYLNKVVVVWNSPKLPSEDLLWPDIGVPI 715

  Fly   767 AVLRAPRNSLNNRFLPFDVIETEAVLSVDDDAHLRHDEILFGFRVWREHRDRVVGFPGRYHAWDL 831
            .|:|..:|||||||||::.|||||:||:|||||||||||:||||||||.|||:|||||||||||:
  Rat   716 MVVRTEKNSLNNRFLPWNEIETEAILSIDDDAHLRHDEIMFGFRVWREARDRIVGFPGRYHAWDI 780

  Fly   832 GNPNGQWHYNSNYSCELSMVLTGAAFVHKYYLYLYTYHLPQAIRDKVDEYMNCEDIAMNFLVSHI 896
              |:..|.||||||||||||||||||.||||.|||:|.:||||||.||||:||||||||||||||
  Rat   781 --PHQSWLYNSNYSCELSMVLTGAAFFHKYYAYLYSYVMPQAIRDMVDEYINCEDIAMNFLVSHI 843

  Fly   897 TRKPPVKVTSRWTFRCPGCPVSLSEDDTHFQERHKCINFFSRVFGYTPLLNTQYRADSILFKTRI 961
            |||||:||||||||||||||.:||.||:||.|||||||||.:|:||.|||.||:|.||:|||||:
  Rat   844 TRKPPIKVTSRWTFRCPGCPQALSHDDSHFHERHKCINFFVKVYGYMPLLYTQFRVDSVLFKTRL 908

  Fly   962 PHDKQKCFKYI 972
            ||||.||||:|
  Rat   909 PHDKTKCFKFI 919

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
botv	NP_523790.1	CC_brat-like	106..>179	CDD:475168	23/75 (31%)
		Exostosin	224..551	CDD:397245	130/346 (38%)
		Glyco_transf_64	714..953	CDD:430488	188/238 (79%)
Extl3	NP_064482.1	TPR_MLP1_2	<71..150	CDD:462316	23/78 (29%)
		Exostosin	190..500	CDD:397245	130/346 (38%)
		Glyco_transf_64	663..900	CDD:430488	188/238 (79%)