Protein Alignment botv and Extl3

DIOPT Version :10

• Sequence 1: NP_523790.1
• Gene: botv / 37198
• FlyBaseID: FBgn0027535
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: NP_061258.2
• Gene: Extl3 / 54616
• MGIID: 1860765
• Length: 919
• Species: Mus musculus
• Alignment Length: 984
• Identity: 473/984 - (48%)
• Similarity: 627/984 - (63%)
• Gaps: 106/984 - (10%)

  Fly    20 GSGGGNEACAPNSSSAQIRHSMGFRTSWMRQFRRYKLPMVLLMLLFLVSCLAYRILSVEQDAPPL 84
            |.|.|.:.|       .:|.|...|.:|        |...|.::|.....:|:..|:...:|.
Mouse    11 GVGNGGQTC-------MLRWSNRIRLTW--------LSFTLFIILVFFPLIAHYYLTTLDEAD-- 58

  Fly    85 DLHRSSPLLDAYEDFSAMRAGDLKMRIE---EMVRIKSTVSVELRELESRRQKLQSDISQYNQKI 146
                     :|.:.....|||.....::   ::.||:.:||.||.:||::||:|.|:|::.|.||
Mouse    59 ---------EAGKRIFGPRAGSELCEVKHVLDLCRIRESVSEELLQLEAKRQELNSEIAKLNLKI 114

  Fly   147 EELKQELLREQTELERLKISVEQAQVAQREAVQRNTPDLALPRSLLPNT----LPRKSNPITGGM 207
            |..|:.:...:.:|.:||..:.|.:.:.:|.:.:|.|.|:||..|||..    ||...  :|.|
Mouse   115 EACKKSIENAKQDLLQLKNVISQTEHSYKELMAQNQPKLSLPIRLLPEKDDAGLPPPK--VTRG- 176

  Fly   208 AASCEMHNCFNHSRCSLTSGFPVYLYDPDEHSVQRKGYDIDGFLKTTLKQTLGYNAHIVKDPKHA 272
               |.:||||::|||.||||||||:||.|:.:.   |..:|..:|...:.|:..|.::.::...|
Mouse   177 ---CRLHNCFDYSRCPLTSGFPVYVYDSDQFAF---GSYLDPLVKQAFQATVRANVYVTENAAIA 235

  Fly   273 CIYLVLVGEALLEQDLLRNNRYAAQEAEHQQPSTPTLENDCPVDMEK-LYSLPYWGGDGRNHVLL 336
            |:|:||||| :.|..:||                       |.|:|| |:|||:|..||.|||::
Mouse   236 CLYVVLVGE-MQEPTVLR-----------------------PADLEKQLFSLPHWRTDGHNHVII 276

  Fly   337 NLARRDLTSHRTNPLYRQNTMRAIVVQSAFEREQFRPGYDLIVPPILGPPGGDVWQECAEMVPAR 401
            ||:|:   |...|.||..:|.||:|.||.|...|:|.|:||:|.|::.......:.|....||.:
Mouse   277 NLSRK---SDTQNLLYNVSTGRAMVAQSTFYAAQYRAGFDLVVSPLVHAMSEPNFMEIPPQVPVK 338

  Fly   402 RKYLLTYQGE-LRPKQSSLNPLDAFILEHLAD--------------MAKGATQDQFVLQFQCVPA 451
            ||||.|:||| :...:|||....:|..|...|              ..:.:..||.:::|.|
Mouse   339 RKYLFTFQGEKIESLRSSLQEARSFEEEMEGDPPADYDDRIIATLKAVQDSKLDQVLVEFTC--- 400

  Fly   452 TEQQEGDSLP-DWTLCGSDSSRRQLLKDSTFSLILPPLNGR-VSSTLMLARIYEALRSGAVPVIL 514
             :.|...||| :|.|||....|.:|||.|||:||:.|.:.. :.|:....|::|||..|||||:|
Mouse   401 -KNQPKPSLPTEWALCGEREDRLELLKLSTFALIITPGDPHLLISSGCATRLFEALEVGAVPVVL 464

  Fly   515 GADELRLPYAETVDWRRTALLLPKARITELHFLLRAVQDADLLLLRRQGRLIWERYLSSVQATVD 579
            | ::::|||.:.:.|...||::||.|:||:|||||::.|:|||.:|||||.:||.|.|:..:..:
Mouse   465 G-EQVQLPYHDMLQWNEAALVVPKPRVTEVHFLLRSLSDSDLLAMRRQGRFLWETYFSTADSIFN 528

  Fly   580 TVIASLRDRLGIPPRPVPSVIAQSVFNSTFIPLKSDPPVGLDTEPEES----LGPI--EPPYPSP 638
            ||:|.:|.|:.||..|:...:|..      ||.:|....|.|....::    |||:  ||||.||
Mouse   529 TVLAMIRTRIQIPAAPIREEVAAE------IPHRSGKAAGTDPNMADNGDLDLGPVETEPPYASP 587

  Fly   639 AFRRNYTILRMQAKEAWNDWLDPFYLYPQLPFDPALPSEAKFMGSHTGFRPIGKGLGGAGKEFGE 703
            .:.||:|:........||....||:|:|..||||.|||||||:||.|||||||.|.||:||||..
Mouse   588 KYLRNFTLTVTDCYRGWNSAPGPFHLFPHTPFDPVLPSEAKFLGSGTGFRPIGGGAGGSGKEFQA 652

  Fly   704 SLGGNYPREQFTIVMLTYEREQVLMDSLGRLYGLPYLHKVVVVWNSPKPPLDDLRWPDIGVPVAV 768
            :||||..|||||:||||||||:|||:||.||.|||||:||||||||||.|.:||.|||||||:.|
Mouse   653 ALGGNVQREQFTVVMLTYEREEVLMNSLERLNGLPYLNKVVVVWNSPKLPSEDLLWPDIGVPIMV 717

  Fly   769 LRAPRNSLNNRFLPFDVIETEAVLSVDDDAHLRHDEILFGFRVWREHRDRVVGFPGRYHAWDLGN 833
            :|..:|||||||||::.|||||:||:|||||||||||:||||||||.|||:|||||||||||:
Mouse   718 VRTEKNSLNNRFLPWNEIETEAILSIDDDAHLRHDEIMFGFRVWREARDRIVGFPGRYHAWDI-- 780

  Fly   834 PNGQWHYNSNYSCELSMVLTGAAFVHKYYLYLYTYHLPQAIRDKVDEYMNCEDIAMNFLVSHITR 898
            |:..|.||||||||||||||||||.||||.|||:|.:||||||.||||:||||||||||||||||
Mouse   781 PHQSWLYNSNYSCELSMVLTGAAFFHKYYAYLYSYVMPQAIRDMVDEYINCEDIAMNFLVSHITR 845

  Fly   899 KPPVKVTSRWTFRCPGCPVSLSEDDTHFQERHKCINFFSRVFGYTPLLNTQYRADSILFKTRIPH 963
            |||:||||||||||||||.:||.||:||.|||||||||.:|:||.|||.||:|.||:|||||:||
Mouse   846 KPPIKVTSRWTFRCPGCPQALSHDDSHFHERHKCINFFVKVYGYMPLLYTQFRVDSVLFKTRLPH 910

  Fly   964 DKQKCFKYI 972
            ||.||||:|
Mouse   911 DKTKCFKFI 919

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
botv	NP_523790.1	CC_brat-like	106..>179	CDD:475168	23/75 (31%)
		Exostosin	224..551	CDD:397245	129/344 (38%)
		Glyco_transf_64	714..953	CDD:430488	188/238 (79%)
Extl3	NP_061258.2	Required for interaction with REG3A. /evidence=ECO:0000250|UniProtKB:O43909	1..140		40/154 (26%)
		TPR_MLP1_2	<76..150	CDD:462316	23/73 (32%)
		Exostosin	190..500	CDD:397245	129/344 (38%)
		Glyco_transf_64	663..900	CDD:430488	188/238 (79%)