Protein Alignment botv and ext1

DIOPT Version :10

• Sequence 1: NP_523790.1
• Gene: botv / 37198
• FlyBaseID: FBgn0027535
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: NP_001006730.1
• Gene: ext1 / 448393
• XenbaseID: XB-GENE-867525
• Length: 738
• Species: Xenopus tropicalis
• Alignment Length: 842
• Identity: 229/842 - (27%)
• Similarity: 363/842 - (43%)
• Gaps: 233/842 - (27%)

  Fly   183 PDLALPRSLLPNT----------LPRKSNPITGGM--AASCEMHNCFNHSRCSLTSGFPVYLYDP 235
            ||    .||||.|          .||:.......:  ...|.|.:||:.:.|. .:||.||:|.
 Frog    54 PD----TSLLPFTQGEGDPGSQVSPRQKRDGNSSIYKGKRCRMESCFDLALCR-RNGFKVYIYP- 112

  Fly   236 DEHSVQRKGYDIDGFLKTTLKQTLGYNAHIV----------KDPKHACIYLVLVGEALLEQDLLR 290
                 |:||.          |.:..|. ||:          .||..||::       :|..|.|.
 Frog   113 -----QQKGD----------KLSESYQ-HILAAIESSRLYTSDPSQACLF-------VLSLDTLD 154

  Fly   291 NNRYAAQEAEHQQPSTPTLENDCPVDMEKLYSLPYWGGDGRNHVLLNLARRDLTSHRTNPLYRQN 355
            .::.:.|...:.:              .|:.:|..| .:||||::.||      ...|.|.|.::
 Frog   155 RDQLSPQYVHNLK--------------SKVQNLHLW-NNGRNHLIFNL------YSGTWPDYTED 198

  Fly   356 T----MRAIVVQSAFEREQFRPGYDLIVP------PILGPPGGDVWQECAEMVPARRKYLLTYQG 410
            .    .:|::.:::...|.|||.:|:.:|      |   ..||:........:|..|||:|.::|
 Frog   199 VGFDIGQAMLAKASISTENFRPNFDVSIPLFSKDHP---RTGGEKGFLRFNNIPPMRKYMLVFKG 260

  Fly   411 ELRPKQSSLNPLDAFILEHLADMAKGATQDQFVLQFQCVPATEQQEGDSLPDW-----TLCGSDS 470
                 :..|..:.:.....|..:..|   :..||...|      :.|   .||     ..|..|:
 Frog   261 -----KRYLTGIGSDTRNALYHVHNG---EDVVLLTTC------KHG---KDWQKHKDARCDKDN 308

  Fly   471 SR------RQLLKDSTFSLILPPLNGRVSSTLMLARIYEALRSGAVPVILGADELRLPYAETVDW 529
            :.      |::|.::||.|:  |...|:.|    .|..|||::..|||:| ::...||::|.:||
 Frog   309 AEYEKYDYREMLHNATFCLV--PRGRRLGS----FRFLEALQAACVPVML-SNGWELPFSEVIDW 366

  Fly   530 RRTALLLPKARITELHFLLRAVQDADLLLLRRQGRLIWERYLSSVQATVDTVIASLRDRLGIPPR 594
            .:.|::..:..:.::...:|::....:|.||:|.:.:||.|.|||:..|.|.:..::||
 Frog   367 NQAAVIGDERLLLQIPSTIRSIHQDKILALRQQTQFLWEAYFSSVEKIVLTTLEIIQDR------ 425

  Fly   595 PVPSVIAQSVFNSTFIPLKSDPPVGLDTEPEESLGPIEPPYPSPAFRRNYTILRMQAKEAWNDWL 659
                     :|..                                ..||..:        ||.
 Frog   426 ---------IFKH--------------------------------ISRNSLM--------WNK-- 439

  Fly   660 DPFYLYPQLPFDPALPSEAKFMGSHTGFRPIGKGLGGAGKEFGESLGGNYPREQFTIVMLT---- 720
                 :|...|  .||..:.::|..              ..:..:||...| .:||.|:..
 Frog   440 -----HPGALF--VLPQYSAYLGDF--------------PYYYSNLGAKTP-SKFTAVIHAVTPL 482

  Fly   721 YEREQVLMDSLGRLYGLPYLHKVVVVWNSPKPPLDDLRWPDIGVPVAVLRAPRNSLNNRFLPFDV 785
            ..:.|.::..|..:....|.::::|:||..||.....|||...|||.|:......:::||||:|.
 Frog   483 VSQSQPILKLLVAVAKSQYCYQIIVLWNCDKPLPAKHRWPATTVPVIVIEGESKVMSSRFLPYDN 547

  Fly   786 IETEAVLSVDDDAHLRHDEILFGFRVWREHRDRVVGFPGRYHAWDLGNPNGQWHYNSNYSCELSM 850
            |.|:||||:|:|..|...|:.|.|.||:...:|:||:|.|.|.||  :...:|.|.|.::.:.||
 Frog   548 IVTDAVLSLDEDTVLSTTEVDFAFTVWQSFPERIVGYPARSHFWD--SAKERWGYTSKWTNDYSM 610

  Fly   851 VLTGAAFVHKYYLYLYTYHLPQAIRDKVDEYMNCEDIAMNFLVSHITRKPPVKVT---------- 905
            ||||||..||||.||||.:||.::::.||:..|||||.||||||.:|:.||:|||
 Frog   611 VLTGAATYHKYYHYLYTNYLPASLKNMVDQLANCEDILMNFLVSAVTKLPPIKVTQKKQYKETMM 675

  Fly   906 ------SRWTFRCPGCPVSLSEDDTHFQERHKCINFFSRVFGYTPLLNTQYRADSILFKTRI 961
                  |||.            |..||.:|..|:|.|:..|||.||:::|.|.|.:|||.::
 Frog   676 GQTSRASRWA------------DPDHFAQRQTCMNTFASWFGYMPLIHSQMRLDPVLFKDQV 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
botv	NP_523790.1	CC_brat-like	106..>179	CDD:475168
		Exostosin	224..551	CDD:397245	82/357 (23%)
		Glyco_transf_64	714..953	CDD:430488	102/258 (40%)
ext1	NP_001006730.1	Exostosin	102..388	CDD:397245	82/358 (23%)
		Glyco_transf_64	472..717	CDD:430488	102/258 (40%)