Protein Alignment botv and EXTL3

DIOPT Version :10

• Sequence 1: NP_523790.1
• Gene: botv / 37198
• FlyBaseID: FBgn0027535
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: NP_001431.1
• Gene: EXTL3 / 2137
• HGNCID: 3518
• Length: 919
• Species: Homo sapiens
• Alignment Length: 984
• Identity: 475/984 - (48%)
• Similarity: 628/984 - (63%)
• Gaps: 106/984 - (10%)

  Fly    20 GSGGGNEACAPNSSSAQIRHSMGFRTSWMRQFRRYKLPMVLLMLLFLVSCLAYRILSVEQDAPPL 84
            |:|.|.:.|       .:|.|...|.:|        |...|.::|.....:|:..|:...:|.
Human    11 GAGNGGQTC-------MLRWSNRIRLTW--------LSFTLFVILVFFPLIAHYYLTTLDEAD-- 58

  Fly    85 DLHRSSPLLDAYEDFSAMRAGDLKMRIE---EMVRIKSTVSVELRELESRRQKLQSDISQYNQKI 146
                     :|.:.....|.|:....::   ::.||:.:||.||.:||::||:|.|:|::.|.||
Human    59 ---------EAGKRIFGPRVGNELCEVKHVLDLCRIRESVSEELLQLEAKRQELNSEIAKLNLKI 114

  Fly   147 EELKQELLREQTELERLKISVEQAQVAQREAVQRNTPDLALPRSLLPNT----LPRKSNPITGGM 207
            |..|:.:...:.:|.:||..:.|.:.:.:|.:.:|.|.|:||..|||..    ||...  .|.|
Human   115 EACKKSIENAKQDLLQLKNVISQTEHSYKELMAQNQPKLSLPIRLLPEKDDAGLPPPK--ATRG- 176

  Fly   208 AASCEMHNCFNHSRCSLTSGFPVYLYDPDEHSVQRKGYDIDGFLKTTLKQTLGYNAHIVKDPKHA 272
               |.:||||::|||.||||||||:||.|:...   |..:|..:|...:.|...|.::.::...|
Human   177 ---CRLHNCFDYSRCPLTSGFPVYVYDSDQFVF---GSYLDPLVKQAFQATARANVYVTENADIA 235

  Fly   273 CIYLVLVGEALLEQDLLRNNRYAAQEAEHQQPSTPTLENDCPVDMEK-LYSLPYWGGDGRNHVLL 336
            |:|::|||| :.|..:||                       |.::|| |||||:|..||.|||::
Human   236 CLYVILVGE-MQEPVVLR-----------------------PAELEKQLYSLPHWRTDGHNHVII 276

  Fly   337 NLARRDLTSHRTNPLYRQNTMRAIVVQSAFEREQFRPGYDLIVPPILGPPGGDVWQECAEMVPAR 401
            ||:|:   |...|.||..:|.||:|.||.|...|:|||:||:|.|::.......:.|....||.:
Human   277 NLSRK---SDTQNLLYNVSTGRAMVAQSTFYTVQYRPGFDLVVSPLVHAMSEPNFMEIPPQVPVK 338

  Fly   402 RKYLLTYQGE-LRPKQSSLNPLDAFILEHLAD--------------MAKGATQDQFVLQFQCVPA 451
            ||||.|:||| :...:|||....:|..|...|              ..:.:..||.:::|.|
Human   339 RKYLFTFQGEKIESLRSSLQEARSFEEEMEGDPPADYDDRIIATLKAVQDSKLDQVLVEFTC--- 400

  Fly   452 TEQQEGDSLP-DWTLCGSDSSRRQLLKDSTFSLILPPLNGR-VSSTLMLARIYEALRSGAVPVIL 514
             :.|...||| :|.|||....|.:|||.|||:||:.|.:.| |.|:....|::|||..|||||:|
Human   401 -KNQPKPSLPTEWALCGEREDRLELLKLSTFALIITPGDPRLVISSGCATRLFEALEVGAVPVVL 464

  Fly   515 GADELRLPYAETVDWRRTALLLPKARITELHFLLRAVQDADLLLLRRQGRLIWERYLSSVQATVD 579
            | ::::|||.:.:.|...||::||.|:||:|||||::.|:|||.:|||||.:||.|.|:..:..:
Human   465 G-EQVQLPYQDMLQWNEAALVVPKPRVTEVHFLLRSLSDSDLLAMRRQGRFLWETYFSTADSIFN 528

  Fly   580 TVIASLRDRLGIPPRPVPSVIAQSVFNSTFIPLKSDPPVGLDTEPEES----LGPI--EPPYPSP 638
            ||:|.:|.|:.||..|:....|..      ||.:|....|.|....::    |||:  ||||.||
Human   529 TVLAMIRTRIQIPAAPIREEAAAE------IPHRSGKAAGTDPNMADNGDLDLGPVETEPPYASP 587

  Fly   639 AFRRNYTILRMQAKEAWNDWLDPFYLYPQLPFDPALPSEAKFMGSHTGFRPIGKGLGGAGKEFGE 703
            .:.||:|:.......:||....||:|:|..||||.|||||||:||.|||||||.|.||:||||..
Human   588 RYLRNFTLTVTDFYRSWNCAPGPFHLFPHTPFDPVLPSEAKFLGSGTGFRPIGGGAGGSGKEFQA 652

  Fly   704 SLGGNYPREQFTIVMLTYEREQVLMDSLGRLYGLPYLHKVVVVWNSPKPPLDDLRWPDIGVPVAV 768
            :||||.||||||:||||||||:|||:||.||.|||||:||||||||||.|.:||.|||||||:.|
Human   653 ALGGNVPREQFTVVMLTYEREEVLMNSLERLNGLPYLNKVVVVWNSPKLPSEDLLWPDIGVPIMV 717

  Fly   769 LRAPRNSLNNRFLPFDVIETEAVLSVDDDAHLRHDEILFGFRVWREHRDRVVGFPGRYHAWDLGN 833
            :|..:|||||||||::.|||||:||:|||||||||||:||||||||.|||:|||||||||||:
Human   718 VRTEKNSLNNRFLPWNEIETEAILSIDDDAHLRHDEIMFGFRVWREARDRIVGFPGRYHAWDI-- 780

  Fly   834 PNGQWHYNSNYSCELSMVLTGAAFVHKYYLYLYTYHLPQAIRDKVDEYMNCEDIAMNFLVSHITR 898
            |:..|.||||||||||||||||||.||||.|||:|.:||||||.||||:||||||||||||||||
Human   781 PHQSWLYNSNYSCELSMVLTGAAFFHKYYAYLYSYVMPQAIRDMVDEYINCEDIAMNFLVSHITR 845

  Fly   899 KPPVKVTSRWTFRCPGCPVSLSEDDTHFQERHKCINFFSRVFGYTPLLNTQYRADSILFKTRIPH 963
            |||:||||||||||||||.:||.||:||.|||||||||.:|:||.|||.||:|.||:|||||:||
Human   846 KPPIKVTSRWTFRCPGCPQALSHDDSHFHERHKCINFFVKVYGYMPLLYTQFRVDSVLFKTRLPH 910

  Fly   964 DKQKCFKYI 972
            ||.||||:|
Human   911 DKTKCFKFI 919

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
botv	NP_523790.1	CC_brat-like	106..>179	CDD:475168	23/75 (31%)
		Exostosin	224..551	CDD:397245	131/344 (38%)
		Glyco_transf_64	714..953	CDD:430488	188/238 (79%)
EXTL3	NP_001431.1	Required for interaction with REG3A. /evidence=ECO:0000269|PubMed:27830702	1..140		39/154 (25%)
		TPR_MLP1_2	<71..150	CDD:462316	23/78 (29%)
		Exostosin	190..500	CDD:397245	131/344 (38%)
		Glyco_transf_64	663..900	CDD:430488	188/238 (79%)