Protein Alignment botv and EXT2

DIOPT Version :10

• Sequence 1: NP_523790.1
• Gene: botv / 37198
• FlyBaseID: FBgn0027535
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: XP_011518252.1
• Gene: EXT2 / 2132
• HGNCID: 3513
• Length: 764
• Species: Homo sapiens
• Alignment Length: 993
• Identity: 269/993 - (27%)
• Similarity: 430/993 - (43%)
• Gaps: 275/993 - (27%)

  Fly    19 TGSGGGNEACAPNSSSAQIRHSMGFRTSWMRQFRRYKLPMVLLMLLFLVSCLAYRILSVEQDAPP 83
            :|||||            :||.:..:..|...:..         ||||:..|    |..|::|..
Human     5 SGSGGG------------LRHPLRCQKPWDESYSE---------LLFLLEML----LECEEEAVC 44

  Fly    84 LDLHRS------SPLLDAYEDFSAMRAGDLKMRIEEMVRIKSTVSVELRELESRRQKLQSDISQY 142
            :.:..|      .|.|..            :|:.:..:...:..|:.|..|      :.:.:.|:
Human    45 VIMCASVKYNIRGPALIP------------RMKTKHRIYYITLFSIVLLGL------IATGMFQF 91

  Fly   143 NQKIEELKQELLREQTELERLKISVEQAQVAQREAVQRNTPDLALPRSLLPNTLPRKSNPITGGM 207
            .....|...:.            :||:..:       |:.|.:.||..   :.:|.:.:
Human    92 WPHSIESSNDW------------NVEKRSI-------RDVPVVRLPAD---SPIPERGD------ 128

  Fly   208 AASCEMHNCFNHSRCSLT--SGFPVYLYDPDEHSVQRKGYDIDGF---LKTTLKQTLGYNA---- 263
             .||.||.||:..||...  :...||:|       ..|.| :|.|   :..|:.:.  ||.
Human   129 -LSCRMHTCFDVYRCGFNPKNKIKVYIY-------ALKKY-VDDFGVSVSNTISRE--YNELLMA 182

  Fly   264 -----HIVKDPKHACIYLVLVGEALLEQDLLRNNRYAAQEAEHQQPSTPTLENDCPVDMEKLYSL 323
                 :...|...||:::..:       |:|..|....:|.                 .:.:..|
Human   183 ISDSDYYTDDINRACLFVPSI-------DVLNQNTLRIKET-----------------AQAMAQL 223

  Fly   324 PYWGGDGRNHVLLNLARRDLTSHRTNPLYRQNTMRAIVVQSAFEREQFRPGYDLIVPPILGPPGG 388
            ..| ..|.||:|.|:.......:.|.....::  ||::....|....:|.|||:.: |:..|...
Human   224 SRW-DRGTNHLLFNMLPGGPPDYNTALDVPRD--RALLAGGGFSTWTYRQGYDVSI-PVYSPLSA 284

  Fly   389 DVWQECAEMVPARRKY-LLTYQGELRPKQSSLNPLDAFILEH-----LADMAKGATQDQFVLQFQ 447
            :|  :..|..|..|:| ||:.|..|.|:..  ..|:|..::|     :.|.....::....::.:
Human   285 EV--DLPEKGPGPRQYFLLSSQVGLHPEYR--EDLEALQVKHGESVLVLDKCTNLSEGVLSVRKR 345

  Fly   448 CVPATEQQEGDSLPDWTLCGSDSSRRQLLKDSTFSLILPPLNGRVSSTLMLARIYEALRSGAVPV 512
            |    .:.:....|            |:|:::||.::|.      .:.|..|.:.:.|::|.|||
Human   346 C----HKHQVFDYP------------QVLQEATFCVVLR------GARLGQAVLSDVLQAGCVPV 388

  Fly   513 ILGADELRLPYAETVDWRRTALLLPKARITELHFLLRAVQDADLLLLRRQGRLIWERYLSSVQAT 577
            :: ||...||::|.:||:|.::::|:.::::::.:|:::....:..::||.|..||.|..|::|.
Human   389 VI-ADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQARWFWEAYFQSIKAI 452

  Fly   578 VDTVIASLRDRLGIPPRPVPSVIAQSVFNSTFIPLKSDPPVGLDTEPEESLGPIEPPYPSPAFRR 642
            ....:..:.||:                                             ||..|.
Human   453 ALATLQIINDRI---------------------------------------------YPYAAI-- 470

  Fly   643 NYTILRMQAKEAWND-----W---LDPFYLYPQLPFDPALPSEAKFMGSHTGFRPIGKGLGGAGK 699
                    :.|.|||     |   .:|.:|       |.:|
Human   471 --------SYEEWNDPPAVKWGSVSNPLFL-------PLIP------------------------ 496

  Fly   700 EFGESLGGNYPREQ-FTIVMLTYEREQVLMDSLGRLYGLPYLHKVVVVWNSP-KPPLDDLRWPDI 762
                      |:.| ||.::|||:|.:.|...:..:..:|.|.|::||||:. |.|.:|..||.|
Human   497 ----------PQSQGFTAIVLTYDRVESLFRVITEVSKVPSLSKLLVVWNNQNKNPPEDSLWPKI 551

  Fly   763 GVPVAVLRAPRNSLNNRFLPFDVIETEAVLSVDDD-AHLRHDEILFGFRVWREHRDRVVGFPGRY 826
            .||:.|:|...|.|:|||.|:|.|||||||::||| ..|..||:.||:.||||..||:||:|||.
Human   552 RVPLKVVRTAENKLSNRFFPYDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDRLVGYPGRL 616

  Fly   827 HAWDLGNPNGQWHYNSNYSCELSMVLTGAAFVHKYYLYLYTYHLPQAIRDKVDEYMNCEDIAMNF 891
            |.||  :...:|.|.|.::.|:|||||||||.|||:.|||||.:|..|::.||.:||||||||||
Human   617 HLWD--HEMNKWKYESEWTNEVSMVLTGAAFYHKYFNYLYTYKMPGDIKNWVDAHMNCEDIAMNF 679

  Fly   892 LVSHITRKPPVKVTSRWTFRCPGCPV--SLSEDDTHFQERHKCINFFSRVFGYTPLLNTQYRADS 954
            ||:::|.|..:|||.|..|:||.|..  .||.|.||..||.:|||.|:.|||..||...::|||.
Human   680 LVANVTGKAVIKVTPRKKFKCPECTAIDGLSLDQTHMVERSECINKFASVFGTMPLKVVEHRADP 744

  Fly   955 ILFKTRIPHDKQKCFKYI 972
            :|:|...| :|.|.|..|
Human   745 VLYKDDFP-EKLKSFPNI 761

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
botv	NP_523790.1	CC_brat-like	106..>179	CDD:475168	8/72 (11%)
		Exostosin	224..551	CDD:397245	72/346 (21%)
		Glyco_transf_64	714..953	CDD:430488	124/242 (51%)
EXT2	XP_011518252.1	Exostosin	146..426	CDD:397245	72/344 (21%)
		Glyco_transf_64	502..743	CDD:430488	124/242 (51%)