Protein Alignment botv and EXT1

DIOPT Version :10

• Sequence 1: NP_523790.1
• Gene: botv / 37198
• FlyBaseID: FBgn0027535
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: NP_000118.2
• Gene: EXT1 / 2131
• HGNCID: 3512
• Length: 746
• Species: Homo sapiens
• Alignment Length: 846
• Identity: 230/846 - (27%)
• Similarity: 367/846 - (43%)
• Gaps: 214/846 - (25%)

  Fly   175 REAVQRNTPDLALPRSLLPNTL-------------------PRKSNPITGGM--AASCEMHNCFN 218
            |..:...:||...||  .|:.|                   ||:.......:  ...|.|.:||:
Human    43 RNGLHHPSPDHFWPR--FPDALRPFVPWDQLENEDSSVHISPRQKRDANSSIYKGKKCRMESCFD 105

  Fly   219 HSRCSLTSGFPVYLYDPDEHSVQRKGYDIDGFLKTTLKQTLGYNAHIVKDPKHACIYLVLVGEAL 283
            .:.|. .:||.||:|.      |:||..|....:..|....| :.....||..||::       :
Human   106 FTLCK-KNGFKVYVYP------QQKGEKIAESYQNILAAIEG-SRFYTSDPSQACLF-------V 155

  Fly   284 LEQDLLRNNRYAAQEAEHQQPSTPTLENDCPVDMEKLYSLPYWGGDGRNHVLLNLARRDLTSHRT 348
            |..|.|..::.:.|...:.:              .|:.||..| .:||||::.||      ...|
Human   156 LSLDTLDRDQLSPQYVHNLR--------------SKVQSLHLW-NNGRNHLIFNL------YSGT 199

  Fly   349 NPLYRQNT----MRAIVVQSAFEREQFRPGYDLIVP------PILGPPGGDVWQECAEMVPARRK 403
            .|.|.::.    .:|::.:::...|.|||.:|:.:|      |..|...|.:   ....:|..||
Human   200 WPDYTEDVGFDIGQAMLAKASISTENFRPNFDVSIPLFSKDHPRTGGERGFL---KFNTIPPLRK 261

  Fly   404 YLLTYQGELRPKQSSLNPLDAFILEHLADMAKGATQDQFVLQFQCVPATE-QQEGDSLPDWTLCG 467
            |:|.::|     :..|..:.:.....|..:..|   :..||...|....: |:..||     .|.
Human   262 YMLVFKG-----KRYLTGIGSDTRNALYHVHNG---EDVVLLTTCKHGKDWQKHKDS-----RCD 313

  Fly   468 SDSSR------RQLLKDSTFSLILPPLNGRVSSTLMLARIYEALRSGAVPVILGADELRLPYAET 526
            .|::.      |::|.::||.|:  |...|:.|    .|..|||::..|||:| ::...||::|.
Human   314 RDNTEYEKYDYREMLHNATFCLV--PRGRRLGS----FRFLEALQAACVPVML-SNGWELPFSEV 371

  Fly   527 VDWRRTALLLPKARITELHFLLRAVQDADLLLLRRQGRLIWERYLSSVQATVDTVIASLRDRLGI 591
            ::|.:.|::..:..:.::...:|::....:|.||:|.:.:||.|.|||:..|.|.:..::||
Human   372 INWNQAAVIGDERLLLQIPSTIRSIHQDKILALRQQTQFLWEAYFSSVEKIVLTTLEIIQDR--- 433

  Fly   592 PPRPVPSVIAQSVFNSTFIPLKSDPPVGLDTEPEESLGPIEPPYPSPAFRRNYTILRMQAKEAWN 656
                    |.:.:..::.|..|.  |.||...|:                             ::
Human   434 --------IFKHISRNSLIWNKH--PGGLFVLPQ-----------------------------YS 459

  Fly   657 DWLDPF-YLYPQLPFDPALPSEAKFMGSHTGFRPIGKGLGGAGKEFGESLGGNYPREQFTIVMLT 720
            .:|..| |.|..|                 |.:|..|                     ||.|:..
Human   460 SYLGDFPYYYANL-----------------GLKPPSK---------------------FTAVIHA 486

  Fly   721 ----YEREQVLMDSLGRLYGLPYLHKVVVVWNSPKPPLDDLRWPDIGVPVAVLRAPRNSLNNRFL 781
                ..:.|.::..|.......|..:::|:||..||.....|||...|||.|:......:::|||
Human   487 VTPLVSQSQPVLKLLVAAAKSQYCAQIIVLWNCDKPLPAKHRWPATAVPVVVIEGESKVMSSRFL 551

  Fly   782 PFDVIETEAVLSVDDDAHLRHDEILFGFRVWREHRDRVVGFPGRYHAWDLGNPNGQWHYNSNYSC 846
            |:|.|.|:||||:|:|..|...|:.|.|.||:...:|:||:|.|.|.||  |...:|.|.|.::.
Human   552 PYDNIITDAVLSLDEDTVLSTTEVDFAFTVWQSFPERIVGYPARSHFWD--NSKERWGYTSKWTN 614

  Fly   847 ELSMVLTGAAFVHKYYLYLYTYHLPQAIRDKVDEYMNCEDIAMNFLVSHITRKPPVKVT------ 905
            :.||||||||..||||.|||:::||.::::.||:..|||||.||||||.:|:.||:|||
Human   615 DYSMVLTGAAIYHKYYHYLYSHYLPASLKNMVDQLANCEDILMNFLVSAVTKLPPIKVTQKKQYK 679

  Fly   906 ----------SRWTFRCPGCPVSLSEDDTHFQERHKCINFFSRVFGYTPLLNTQYRADSILFKTR 960
                      |||.            |..||.:|..|:|.|:..|||.||:::|.|.|.:|||.:
Human   680 ETMMGQTSRASRWA------------DPDHFAQRQSCMNTFASWFGYMPLIHSQMRLDPVLFKDQ 732

  Fly   961 I 961
            :
Human   733 V 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
botv	NP_523790.1	CC_brat-like	106..>179	CDD:475168	1/3 (33%)
		Exostosin	224..551	CDD:397245	81/343 (24%)
		Glyco_transf_64	714..953	CDD:430488	102/258 (40%)
EXT1	NP_000118.2	Exostosin	110..396	CDD:397245	81/344 (24%)
		Glyco_transf_64	480..725	CDD:430488	102/258 (40%)