Protein Alignment Topors and toporsa

DIOPT Version :8

• Sequence 1: NP_001261083.1
• Gene: Topors / 37188
• FlyBaseID: FBgn0267351
• Length: 1038
• Species: Drosophila melanogaster
• Sequence 2: NP_001292484.1
• Gene: toporsa / 324197
• ZFINID: ZDB-GENE-030131-6401
• Length: 999
• Species: Danio rerio
• Alignment Length: 1064
• Identity: 244/1065 (23%)
• Similarity: 408/1065 (38%)
• Gaps: 274/1065 (26%)

  Fly    97 SPPPNCAICLSRCRRKCFTDSCMHQFCFKCLCEWSKIKPECPLCKQPFRTIIHNVRTLDDYDRYP 161
            ||...|.|||...:...:.|.|:|:|||.|:.||||.|.|||||||||.:..|.:::.|||.|:.
Zfish    23 SPESKCPICLDHFKNISYLDVCLHKFCFCCIHEWSKNKAECPLCKQPFNSFYHTIKSEDDYKRFD 87

  Fly   162 VQTTSPVPTENPSLRYHIVRRPRYTPLVQNQAVIVNDIEAAIAAGAAGEDVLSAAEVAAGRRSYS 226
            ::     ||||.|......:|.||      :..:..|                       ||...
Zfish    88 LR-----PTENGSFGNMAGQRFRY------RTTLTGD-----------------------RRPVQ 118

  Fly   227 R-----------FEPYRSELMNYYQHDQD--------------ASTSGSLSQL-------WRRYV 259
            |           ||..|..|..  :|::|              .|...||..|       :||.:
Zfish   119 RRTSPPPDHGIIFEGLRGSLPQ--RHNRDLHSMIRRLTVRQRRESEGRSLRSLQDQEVVKFRRAL 181

  Fly   260 YDRKLYALPVSDSVTGHFREWSARFYRNNPAQIHRLMPWIHRDIMCLLRNAAHSVNTVMTLMSDL 324
            |.|.:....|.|.  |..||.||.|::.|||.:|||:||:.|::..|.......||.|..::..|
Zfish   182 YRRGVQVQSVQDG--GRTRETSAEFFKRNPACLHRLVPWLRRELTVLYGAHGSLVNIVQHIIMTL 244

  Fly   325 LPMTSLLGPTFRRRLSPYLGERTSHFIHELFNFARSPYDINGYDHVVQYSARVAEEVEVDLLDMV 389
            :...:|.....:..|.|:|...|.||:||..:|||||:::..||....|.           |...
Zfish   245 ITRHNLDDQAVQHELRPFLLSHTEHFLHEFLSFARSPFNMEAYDQRAVYD-----------LPRP 298

  Fly   390 ETQSSNGDDLNLEVGDSDADAINAGFSPDWSPPRVRPS-TSVIVTNPGATHSFSVTMASDGSELP 453
            ..:||:.::..:.:.:.:::::.:| :.|::.|||..| |:.....||.::|      |:.|::.
Zfish   299 SGESSSSENSVIAISEDESESLVSG-AQDFATPRVTSSQTAWDDETPGPSYS------SERSQVL 356

  Fly   454 GISIRRT---TNVGSQTVAINLSMRRPAAVASEEPEVIEIDDGDAAANAEVAAINDGSNTSRRHA 515
            .:.:|.:   ::||...:.|       |||..:          |..||
Zfish   357 PVHVRDSDSDSSVGEAVMPI-------AAVRHQ----------DHPAN----------------- 387

  Fly   516 GATLPVTAHIELESSSSSGDEDECVFVLELKPPHMRTPEQVSLDSNSDSDVVFVNEQHEAAPDAI 580
                |.|...| |..|||.||| ||.:..:||...||||.|.|.|:|::.    ..:..|:|
Zfish   388 ----PSTIQPE-EDHSSSNDED-CVIIGYVKPVAERTPELVQLSSDSENS----ETEQNASP--- 439

  Fly   581 AENRSTQSPLDLASRDQGLFMGPSTSGAAANRGKNWKLVMAQTRRLDQLRTLR----SIRSKKS- 640
               |::|:|..:.      |:..|.:...|::                 |.||    |.||.:.
Zfish   440 ---RNSQAPQHIR------FISDSDASPTASQ-----------------RPLRGPASSSRSFEDT 478

  Fly   641 ----RRSSMPARSDSGSSPSSCSSSSFHFSSSSDEDSSDSSTTNSEPPKKK-------------- 687
                |::|....:.|||...|..|...|.||...:......:.|.:..:|:
Zfish   479 SIQLRKNSKYDNTFSGSREGSSQSKRIHSSSHRKKQPLCKESKNKQRGEKETSRHSSSYWHSYSY 543

  Fly   688 -----SRKRVANNK-------RSKKESIGKRTSRKRKAKD--QNMEMLEQQQISQKKPQRQPESS 738
                 |||......       ||..:..|.|:..||:.:|  .........:|||...:.:..|.
Zfish   544 YSHDNSRKAYTETSSSYTSYYRSVNDQFGSRSHGKRRCRDLLDRSRSRSNSRISQSNRRNRSRSR 608

  Fly   739 SDSP-SSSDDESGGDSSESSGQPNTN-NNKSSSDSDDDSAV----NMQLSALRATLKAEATLEDR 797
            |:|. |.|:..:...|..:||:..:| .|:|.|.|...::.    |.:.|...:. |:::...:|
Zfish   609 SNSRISRSNQRNRSHSRSNSGKSQSNRRNRSCSRSYSRTSPFNERNRRHSRSNSR-KSQSNRHNR 672

  Fly   798 KPVKLELQLPDDDQAGPLHSRMTPSPREDN--EPGCS-------------------------APK 835
            ...:...:....::....|||......:.|  ...||                         :.:
Zfish   673 SCSRSYSRTSPFNERNRRHSRSNSRKSQSNRHNRSCSRSYSRTSPFNQRNRRHSRSNSRISQSSR 737

  Fly   836 RRRSCSHSN-----------QSSQSASLASSSTATSSSAPLSSFAWGAAGFSGDPLMRGHPAMEE 889
            :.||.|.||           ..|:|:|..|.|:..:.|...|:|...::.:      :......:
Zfish   738 QNRSLSRSNSRKGYSNRRNRNHSRSSSRVSQSSQRNRSHSRSNFRIKSSSY------KSQDEKYQ 796

  Fly   890 HDIANSLI------ELSTLTQPVNIGLFNEHYNSAENSMGMLSNTLCDSPQTLAADDANLENYFD 948
            ..::.||.      ..|..:..:|.....:...|..:|. |.|::   |.||...|....:..:.
Zfish   797 RSLSRSLYSNNDVRSRSRSSSRINTSSRQDRRRSRSSSR-MNSSS---SRQTSCHDKYGKKRMYK 857

  Fly   949 TDADPEASRERDAYSLEAAIDVVGESELQIAEDTATATEEQDEEDEEDEDQEEDDQEEEKAAEEE 1013
            |....:.||:..:.|:..:.:|.|:.:           :::..:..:......||:.|..:....
Zfish   858 TKHHEKPSRQSSSKSVGDSDEVGGKKK-----------KKKHTKRRKTRSPSIDDRSEGHSQRHH 911

  Fly  1014 EEEEEDDDDSDNHDENDENQGLLP 1037
            :.:::....|..|:..:..:.|.|
Zfish   912 KRKKKHKKKSKRHNSKERTRKLSP 935

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Topors	NP_001261083.1	RING	102..144	CDD:238093	24/42 (57%)
toporsa	NP_001292484.1	RING-HC_Topors	28..67	CDD:319488	21/39 (54%)
		RING-HC finger (C3HC4-type)	28..66	CDD:319488	20/38 (53%)
		RRM	635..>749	CDD:330708	19/115 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C314171465
eggNOG	1	0.900				E1_KOG4430
Hieranoid	1	1.000
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	194	1.000	Inparanoid score	I3751
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000				FOG0005422
OrthoInspector	1	1.000				T597235
orthoMCL	1	0.900				OOG5_133270
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R9253
TreeFam	1	0.960
ZFIN	0	0.000	Not matched by this tool.
	9	8.770