Protein Alignment MetRS and metG

DIOPT Version :10

• Sequence 1: NP_611382.1
• Gene: MetRS / 37177
• FlyBaseID: FBgn0034401
• Length: 1022
• Species: Drosophila melanogaster
• Sequence 2: NP_416617.1
• Gene: metG / 946643
• ECOCYCID: EG10586
• Length: 677
• Species: Escherichia coli
• Alignment Length: 671
• Identity: 181/671 - (26%)
• Similarity: 292/671 - (43%)
• Gaps: 92/671 - (13%)

  Fly   254 RNVLITSALPYVNNVPHLGNIIGCVLSADIYARYSRSAGYNTLLICGTDEYGTATENKALAENLT 318
            :.:|:|.||||.|...|||:::..: .||::.||.|..|:....||..|.:||....||....:|
E. coli     6 KKILVTCALPYANGSIHLGHMLEHI-QADVWVRYQRMRGHEVNFICADDAHGTPIMLKAQQLGIT 69

  Fly   319 PREICDKYFELHNAIYRWFGIGFDYFGRTTTQEQTDIVQEAFKDVLKAGYIITESVEQLLCQKCD 383
            |.::..:..:.|...:..|.|.:|.:..|.::|...:.:..:..:.:.|:|...::.||...:..
E. coli    70 PEQMIGEMSQEHQTDFAGFNISYDNYHSTHSEENRQLSELIYSRLKENGFIKNRTISQLYDPEKG 134

  Fly   384 RFLADRFVEGTCPHPGCGYEDARGDQCDKCGKLVNATELIRPRCKVCNSAPVLRSSDQLFIDLPK 448
            .||.||||:||||.  |...|..||.|:.||...:.||||.|:..|..:.||:|.|:..|.|||.
E. coli   135 MFLPDRFVKGTCPK--CKSPDQYGDNCEVCGATYSPTELIEPKSVVSGATPVMRDSEHFFFDLPS 197

  Fly   449 AEPQLKEWVDKSEGGWTHNAKVITRAWLKEGLKPRCITRDLKWGIPVPHEGFE-----KKVFYVW 508
            ....|:.|.  ..|..........:.|.:.||:...|:||      .|:.|||     .|.||||
E. coli   198 FSEMLQAWT--RSGALQEQVANKMQEWFESGLQQWDISRD------APYFGFEIPNAPGKYFYVW 254

  Fly   509 FDAPFGYVSMTKRY------TKEYQQWWQPAKGTDVELFQFMAKDNVPFHSVVWPSVLLAIN--K 565
            .|||.||:...|..      :..:.::|:  |.:..||:.|:.||.|.|||:.||::|...|  |
E. coli   255 LDAPIGYMGSFKNLCDKRGDSVSFDEYWK--KDSTAELYHFIGKDIVYFHSLFWPAMLEGSNFRK 317

  Fly   566 GHTLVSHIMATEYLNYEDGKFSKSRGIGVFGNDAQETGIPADVW----------RFYLASARPEG 620
            ...|..|    .|:.....|.|||||          |.|.|..|          .:|.|......
E. coli   318 PSNLFVH----GYVTVNGAKMSKSRG----------TFIKASTWLNHFDADSLRYYYTAKLSSRI 368

  Fly   621 QDSSFSWNDLAARNNSELLNNLGNFVNRALVFCEKNFSSTVPGVITTQ---DELVLLALINRELR 682
            .|...:..|...|.|::::|.:.|..:|...|..|.|.    ||:.::   .:|........|:.
E. coli   369 DDIDLNLEDFVQRVNADIVNKVVNLASRNAGFINKRFD----GVLASELADPQLYKTFTDAAEVI 429

  Fly   683 GYINSMEKAKLRDGVRHLLAISRHGNGYMQSQQPWVLLKGTDDQKTRASTIIGLC---VNIACLL 744
            |  .:.|..:....||.::|::...|.|:..|.|||:.|    |:.|.:.:..:|   :|:..:|
E. coli   430 G--EAWESREFGKAVREIMALADLANRYVDEQAPWVVAK----QEGRDADLQAICSMGINLFRVL 488

  Fly   745 ANLLFPYMPTTARTLFGQLNAKQTPLNAEKPLVTLLLPAGHQIGKPAPLFAKLE----QSFIDEL 805
            ...|.|.:|.........||.:.|....::||:      ||::.....|:.:::    ::.::..
E. coli   489 MTYLKPVLPKLTERAEAFLNTELTWDGIQQPLL------GHKVNPFKALYNRIDMRQVEALVEAS 547

  Fly   806 KGKYGGAQA------TNDAAHSQISAADLEKAVQAQADKVRELKASTKDKAIWQPEVTKLLDLKK 864
            |.:...|.|      .:|.....|:..|..|.         :|:.:..:.|.:.....|||.|..
E. coli   548 KEEVKAAAAPVTGPLADDPIQETITFDDFAKV---------DLRVALIENAEFVEGSDKLLRLTL 603

  Fly   865 QLEEAKKKTATAAAPAATPAP 885
            .| ..:|:...:...:|.|.|
E. coli   604 DL-GGEKRNVFSGIRSAYPDP 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MetRS	NP_611382.1	GST_N_5	1..70	CDD:436537
		GST_C_family	63..164	CDD:470672
		PLN02610	248..>850	CDD:215329	171/634 (27%)
		MetRS_RNA	895..938	CDD:238475
		MetRS_RNA	966..1009	CDD:238475
metG	NP_416617.1	metG	6..677	CDD:234655	181/671 (27%)