DRSC/TRiP Functional Genomics Resources

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Protein Alignment: MetRS and MARS2

Sequence 1:NP_611382.1 Gene:MetRS FlyBaseID:FBgn0034401 Length:1022 Species:Drosophila melanogaster
Sequence 2:NP_612404.1 Gene:MARS2 HGNCID:25133 Length:593 Species:Homo sapiens

Alignment Length:586 Identity:146/587 (25%)
Similarity:232/587 (40%) Gaps:94/587 (16%)


  Fly   259 TSALPYVNNVPHLGNIIGCVLSADIYARYSRSAGYNTL---LICGTDEYGTATENKALAENLTPR 320
            |:.:.|||..||:|::...:| ||...|:.|..|.:|.   ...||||:|...:..|....|.|.
Human    48 TTPIFYVNAAPHIGHLYSALL-ADALCRHRRLRGPSTAATRFSTGTDEHGLKIQQAAATAGLAPT 111

  Fly   321 EICDKYFELHNAIYRWFGIGFDYFGRTTTQEQTDIVQEAFKDVLKAGYIITESV-EQLLCQKCDR 384
            |:||:..|....:::..||....|.|||.......||. |..|||:..::.:.| |...|...:.
Human   112 ELCDRVSEQFQQLFQEAGISCTDFIRTTEARHRVAVQH-FWGVLKSRGLLYKGVYEGWYCASDEC 175

  Fly   385 FLADRFVEGTCPHPGCGYEDARGDQCDKCGKLVNATELIRPRCKVCNSAPVLRSSDQLFI-DLPK 448
            ||.:..|   ...||     ..||...               ..:.:..||..:.::.:| .|.:
Human   176 FLPEAKV---TQQPG-----PSGDSFP---------------VSLESGHPVSWTKEENYIFRLSQ 217

  Fly   449 AEPQLKEWVDKSEGGWT----HNAKVITRAWLKEGLKPRCITR---DLKWGIPVPHEGFEKKVFY 506
            ....|:.|:..:....|    |:   :...||.|.|....::|   .|.||||||  |.:.:..|
Human   218 FRKPLQRWLRGNPQAITPEPFHH---VVLQWLDEELPDLSVSRRSSHLHWGIPVP--GDDSQTIY 277

  Fly   507 VWFDAPFGYVSMTKRYTKEYQQWWQPAKGTDVELFQFMAKDNVPFHSVVWPSVLLAINKGHTLVS 571
            ||.||...|:::......|::.|| ||..      ..:.||.:.||::.||:.||  ..|.:...
Human   278 VWLDALVNYLTVIGYPNAEFKSWW-PATS------HIIGKDILKFHAIYWPAFLL--GAGMSPPQ 333

  Fly   572 HIMATEYLNYEDGKFSKSRGIGVFGNDAQETGIPADVWRFYLASARPEGQDSSFSWNDLAARNNS 636
            .|....:......|.|||.| .|............|.:|::|........|..:....:....||
Human   334 RICVHSHWTVCGQKMSKSLG-NVVDPRTCLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNS 397

  Fly   637 ELLNNLGNFVNRAL-----------VFCEKNFSSTVPGVI------TTQDELVL--LALINRELR 682
            ||.:.||..:||..           .||...|.|. ||::      ..:|..::  :|.:.:::.
Human   398 ELADALGGLLNRCTAKRINPSETYPAFCTTCFPSE-PGLVGPSVRAQAEDYALVSAVATLPKQVA 461

  Fly   683 GYINSMEKAKLRDGVRHLLAISRHGNGYMQSQQPWVLLKGTDDQKTRASTIIGLCVNIACLLANL 747
            .:.::....|..:.|...:   |..||::|...||.|...:........|::.:.:....:...|
Human   462 DHYDNFRIYKALEAVSSCV---RQTNGFVQRHAPWKLNWESPVDAPWLGTVLHVALECLRVFGTL 523

  Fly   748 LFPYMPTTARTLFGQLNAKQTPLNAEKPLVTL-LLPAGHQIGKPAP------------LFAKLEQ 799
            |.|..|:.|..|..:|....    :|:.|..| .||..:  |.|.|            ||.:|:|
Human   524 LQPVTPSLADKLLSRLGVSA----SERSLGELYFLPRFY--GHPCPFEGRRLGPETGLLFPRLDQ 582

  Fly   800 S 800
            |
Human   583 S 583

Known Domains:


GeneSequenceDomainRegion External IDIdentity
MetRSNP_611382.1 GstA 1..175 CDD:223698
GST_N_family 1..65 CDD:238319
GST_C_family 63..164 CDD:295467
PRK12268 254..812 CDD:237029 146/587 (25%)
MetRS_core 255..625 CDD:173907 100/378 (26%)
Anticodon_Ia_Met 634..763 CDD:153411 32/148 (22%)
MetRS_RNA 828..868 CDD:238475
MetRS_RNA 895..938 CDD:238475
MetRS_RNA 966..1009 CDD:238475
MARS2NP_612404.1 PRK11893 46..581 CDD:237012 144/583 (25%)
'HIGH' region 52..62 6/10 (60%)
'KMSKS' region 347..351 3/4 (75%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
eggNOG 1 0.900 E1_COG0143
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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