Protein Alignment MetRS and MSM1

DIOPT Version :10

• Sequence 1: NP_611382.1
• Gene: MetRS / 37177
• FlyBaseID: FBgn0034401
• Length: 1022
• Species: Drosophila melanogaster
• Sequence 2: NP_011687.1
• Gene: MSM1 / 853081
• SGDID: S000003403
• Length: 575
• Species: Saccharomyces cerevisiae
• Alignment Length: 584
• Identity: 135/584 - (23%)
• Similarity: 224/584 - (38%)
• Gaps: 144/584 - (24%)

  Fly   258 ITSALPYVNNVPHLGNIIGCVLSADIYARYSRSAGYNTLLICGTDEYG----TATENKALAENLT 318
            :|:.:.|.|..||||::...:|| |:|.|:....|..:....||||:|    .|:|:....:
Yeast    17 VTTPIFYPNAKPHLGHLYSSLLS-DVYHRWQLFKGNLSFFTTGTDEHGLKIQCASESNGFDQ--- 77

  Fly   319 PREICDKYFELHNAIYRWFGIGFDYFGRTTTQEQTDIVQEAFKDVLKAGYIITESVEQLLCQKCD 383
            |::..||.:.....:.:.:||.:..|.|||..:..:.|.:.::..||.|||.....:.......:
Yeast    78 PKKFVDKLYPEFVQLDKIYGINYTRFIRTTDPDHIENVMKLWELCLKNGYIYMGEHKGWYSISDE 142

  Fly   384 RFLADRFVEGTCPHPGCGYEDARGDQCDKCGKLVNA---TELIRP-------RCKVCNSAPV--L 436
            .|..:..|          .:|.:.|     ||.:|.   .|::..       |..:.|...|  :
Yeast   143 TFYPESKV----------IKDPKND-----GKYLNTESKNEVVYQSETNYFFRLSLFNKKIVDHI 192

  Fly   437 RSSDQLFIDLPKAEPQLKEWVDKSEGGWTHNAKVITRAWLKEGLKPRCITRDLKWGIPVPHEGFE 501
            |.:........|.:..|||    .|.|.|.....|:|.           :..||||||.|::..:
Yeast   193 RKNPDFIFPASKRDQILKE----LETGGTLPDLSISRP-----------SARLKWGIPTPNDPSQ 242

  Fly   502 KKVFYVWFDAPFGYVS--------------MTKR---------------YTKEYQQWWQPAKGTD 537
            |  .||||||...|:|              :..|               |.||.|:
Yeast   243 K--VYVWFDALCNYLSSIGGIPSILSNATEVVSRHYSDKSNVKGQLLIPYPKEVQR--------- 296

  Fly   538 VELFQFMAKDNVPFHSVVWPSVLLA---------INKGHTLVSHIMATEYLNYEDGKFSKSRGIG 593
             .....:.||...||:|.|||.|||         :..||.|.:.:           |.|||.|..
Yeast   297 -NTIHVIGKDIAKFHTVYWPSFLLAAGLPLPRQIVVHGHWLCNGM-----------KMSKSLGNV 349

  Fly   594 VFGND-AQETGIPADVWRFYLASARPEGQDSSFSWNDLAARNNSELL-NNLGNFVNR-------- 648
            |...| |:..|  ||:.|::|.......:|..|  .:.......||| :..||.:||
Yeast   350 VDPIDMARYYG--ADIVRWFLLENSKLEEDGDF--QEAKLYETRELLVSKWGNLINRCCGSKFNI 410

  Fly   649 ---ALVFCEK-NFSSTVPGVITTQDELV------LLALINRELRGYINSMEKAKLRDGVRHLLAI 703
               .:.|.:| ||...   .|...:.:|      |..|:|:....:...:...:....:||:.:|
Yeast   411 ERAVMKFSDKANFQFQ---EIFQNEPIVSERIENLAKLLNKSQEVFDEKIAIFQYPQLLRHVWSI 472

  Fly   704 SRHGNGYMQSQQPWVLLKGTDDQKTRASTIIGLCVNIACLLANLLFPYMPTTARTLFGQLNAKQ 767
            ....|..:|:.:||      :.:..:...||.|.:..:.:|:.|....:|:.:::...:::..:
Yeast   473 INDANTLVQNSKPW------ERELDQQDNIIFLAMETSRILSILCQSIIPSLSQSFLDRIDVSK 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MetRS	NP_611382.1	GST_N_5	1..70	CDD:436537
		GST_C_family	63..164	CDD:470672
		PLN02610	248..>850	CDD:215329	135/584 (23%)
		MetRS_RNA	895..938	CDD:238475
		MetRS_RNA	966..1009	CDD:238475
MSM1	NP_011687.1	metG	15..550	CDD:273058	135/584 (23%)