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Protein Alignment MetRS and MSM1

DIOPT Version :9

Sequence 1:	NP_611382.1	Gene:	MetRS / 37177	FlyBaseID:	FBgn0034401	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	NP_011687.1	Gene:	MSM1 / 853081	SGDID:	S000003403	Length:	575	Species:	Saccharomyces cerevisiae

Alignment Length:	584	Identity:	135/584 - (23%)
Similarity:	224/584 - (38%)	Gaps:	144/584 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 ITSALPYVNNVPHLGNIIGCVLSADIYARYSRSAGYNTLLICGTDEYG----TATENKALAENLT 318
            :|:.:.|.|..||||::...:|| |:|.|:....|..:....||||:|    .|:|:....:
Yeast    17 VTTPIFYPNAKPHLGHLYSSLLS-DVYHRWQLFKGNLSFFTTGTDEHGLKIQCASESNGFDQ--- 77

  Fly   319 PREICDKYFELHNAIYRWFGIGFDYFGRTTTQEQTDIVQEAFKDVLKAGYIITESVEQLLCQKCD 383
            |::..||.:.....:.:.:||.:..|.|||..:..:.|.:.::..||.|||.....:.......:
Yeast    78 PKKFVDKLYPEFVQLDKIYGINYTRFIRTTDPDHIENVMKLWELCLKNGYIYMGEHKGWYSISDE 142

  Fly   384 RFLADRFVEGTCPHPGCGYEDARGDQCDKCGKLVNA---TELIRP-------RCKVCNSAPV--L 436
            .|..:..|          .:|.:.|     ||.:|.   .|::..       |..:.|...|  :
Yeast   143 TFYPESKV----------IKDPKND-----GKYLNTESKNEVVYQSETNYFFRLSLFNKKIVDHI 192

  Fly   437 RSSDQLFIDLPKAEPQLKEWVDKSEGGWTHNAKVITRAWLKEGLKPRCITRDLKWGIPVPHEGFE 501
            |.:........|.:..|||    .|.|.|.....|:|.           :..||||||.|::..:
Yeast   193 RKNPDFIFPASKRDQILKE----LETGGTLPDLSISRP-----------SARLKWGIPTPNDPSQ 242

  Fly   502 KKVFYVWFDAPFGYVS--------------MTKR---------------YTKEYQQWWQPAKGTD 537
            |  .||||||...|:|              :..|               |.||.|:
Yeast   243 K--VYVWFDALCNYLSSIGGIPSILSNATEVVSRHYSDKSNVKGQLLIPYPKEVQR--------- 296

  Fly   538 VELFQFMAKDNVPFHSVVWPSVLLA---------INKGHTLVSHIMATEYLNYEDGKFSKSRGIG 593
             .....:.||...||:|.|||.|||         :..||.|.:.:           |.|||.|..
Yeast   297 -NTIHVIGKDIAKFHTVYWPSFLLAAGLPLPRQIVVHGHWLCNGM-----------KMSKSLGNV 349

  Fly   594 VFGND-AQETGIPADVWRFYLASARPEGQDSSFSWNDLAARNNSELL-NNLGNFVNR-------- 648
            |...| |:..|  ||:.|::|.......:|..|  .:.......||| :..||.:||
Yeast   350 VDPIDMARYYG--ADIVRWFLLENSKLEEDGDF--QEAKLYETRELLVSKWGNLINRCCGSKFNI 410

  Fly   649 ---ALVFCEK-NFSSTVPGVITTQDELV------LLALINRELRGYINSMEKAKLRDGVRHLLAI 703
               .:.|.:| ||...   .|...:.:|      |..|:|:....:...:...:....:||:.:|
Yeast   411 ERAVMKFSDKANFQFQ---EIFQNEPIVSERIENLAKLLNKSQEVFDEKIAIFQYPQLLRHVWSI 472

  Fly   704 SRHGNGYMQSQQPWVLLKGTDDQKTRASTIIGLCVNIACLLANLLFPYMPTTARTLFGQLNAKQ 767
            ....|..:|:.:||      :.:..:...||.|.:..:.:|:.|....:|:.:::...:::..:
Yeast   473 INDANTLVQNSKPW------ERELDQQDNIIFLAMETSRILSILCQSIIPSLSQSFLDRIDVSK 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MetRS	NP_611382.1	GST_N_5	1..70	CDD:436537
		GST_C_family	63..164	CDD:470672
		PLN02610	248..>850	CDD:215329	135/584 (23%)
		MetRS_RNA	895..938	CDD:238475
		MetRS_RNA	966..1009	CDD:238475
MSM1	NP_011687.1	metG	15..550	CDD:273058	135/584 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Software error:

Can't use an undefined value as an ARRAY reference at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 1034.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-
Hieranoid	0	0.000	Not matched by this tool.