DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MetRS and AT4G13780

DIOPT Version :9

Sequence 1:	NP_611382.1	Gene:	MetRS / 37177	FlyBaseID:	FBgn0034401	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	NP_193114.1	Gene:	AT4G13780 / 827012	AraportID:	AT4G13780	Length:	797	Species:	Arabidopsis thaliana

Alignment Length:	827	Identity:	349/827 - (42%)
Similarity:	482/827 - (58%)	Gaps:	95/827 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 TAPKEIKEERTVLPKPGERNVLITSALPYVNNVPHLGNIIGCVLSADIYARYSRSAGYNTLLICG 300
            ::||        ||.||:||:||||||||||||||||||||||||||:||||.|..|||.:.|||
plant     7 SSPK--------LPIPGKRNILITSALPYVNNVPHLGNIIGCVLSADVYARYCRLRGYNAIYICG 63

  Fly   301 TDEYGTATENKALAENLTPREICDKYFELHNAIYRWFGIGFDYFGRTTTQEQTDIVQEAFKDVLK 365
            |||||||||.|||.||.||:||||||..:|..:|.||||.||.||||:|.|||::.|..|..:..
plant    64 TDEYGTATETKALEENCTPKEICDKYHAIHKEVYDWFGISFDKFGRTSTPEQTEVCQAIFNKLWD 128

  Fly   366 AGYIITESVEQLLCQKCDRFLADRFVEGTCPHPGCGYEDARGDQCDKCGKLVNATELIRPRCKVC 430
            ..::...:::||.|..|.:|||||.|||:||..||.|:.||||||:|||||:|.|||..|:||||
plant   129 NKWLSENTMQQLYCDTCKKFLADRLVEGSCPFEGCNYDSARGDQCEKCGKLLNPTELKDPKCKVC 193

  Fly   431 NSAPVLRSSDQLFIDLPKAEPQLKEWVDKSE--GGWTHNAKVITRAWLKEGLKPRCITRDLKWGI 493
            .:.|.:|.:|.|||:||..:.:|:.::.|:.  |.|:.||...|.|||::||:.||||||||||:
plant   194 QNTPRIRDTDHLFIELPLLKDRLEAYIKKTSVTGSWSQNAIQTTNAWLRDGLRQRCITRDLKWGV 258

  Fly   494 PVPHEGFEKKVFYVWFDAPFGYVSMTKRYTKEYQQWWQPAKGTDVELFQFMAKDNVPFHSVVWPS 558
            |||||.::.||||||||||.||||:|..||.|:::||:..:  :|||:|||.|||||||:|::||
plant   259 PVPHEKYKDKVFYVWFDAPIGYVSITSCYTSEWEKWWKNPE--NVELYQFMGKDNVPFHTVMFPS 321

  Fly   559 VLLAINKGHTLVSHIMATEYLNYEDGKFSKSRGIGVFGNDAQETGIPADVWRFYLASARPEGQDS 623
            ..|...:..||:..|..||||||||||||||:|:||||||.::|.||.:|||:||.:.|||..|:
plant   322 TQLGTEENWTLMKTISVTEYLNYEDGKFSKSKGVGVFGNDVKDTNIPVEVWRYYLLTNRPEVSDT 386

  Fly   624 SFSWNDLAARNNSELLNNLGNFVNRALVFCEK----NFSSTVPGVITTQDELVLLAL---INREL 681
            ||||.||.|:.|.|||:||||||||.|.|..|    .:.|.:|.....:...:..:|   :.:.:
plant   387 SFSWTDLQAKLNGELLSNLGNFVNRVLSFIAKPDNAGYGSVIPDAHDAESHSLTKSLAEKVEKFV 451

  Fly   682 RGYINSMEKAKLRDGVRHLLAISRHGNGYMQSQQPWVLLKGTDDQKTRASTIIGLCVNIACLLAN 746
            ..|:.:|||.||:.|::..:.||..||.|:|:.|.|.|.|   :.|...:.:|.....:..|||.
plant   452 AEYVEAMEKVKLKQGLKTAMLISSEGNYYLQASQFWKLYK---EDKPLCAVVIRTAAGLVHLLAQ 513

  Fly   747 LLFPYMPTTARTLFGQLN-AKQTPLNAEKPLVTL------LLPAGHQIGKPAPLFAKLEQSFIDE 804
            ||.|:||:.:..:|.||| ..|..|:.|:..|.|      :||..|:||.|.|||.:||...:..
plant   514 LLEPFMPSFSCEVFKQLNLPPQFSLSDERGEVLLASRPWDILPPSHRIGTPQPLFKELENDEVAR 578

  Fly   805 LKGKYGGAQATNDAAHSQISAADLEKAVQAQADKVRELKASTKDKAIWQPEVTKLLDLKKQLEEA 869
            .:.|:.|:|:...|.....:.||       |.:|                  |||.|.|||...:
plant   579 YREKFAGSQSDRRARDEAANLAD-------QLNK------------------TKLSDAKKQKASS 618

  Fly   870 KKKTATAAAPAATPAPSNGSQSVQDLEKA-IQEQGDKVRKLKGSTKDKTVWQPEVNI-------- 925
            |........|||.          :::..| :..:..|:.|.:...|...::..|:::
plant   619 KGGGKPKPQPAAD----------REITMARLDIRVGKIVKAEKHPKADALYVEEIDVGGGEIRTV 673

  Fly   926 ---------LLDLKKQLEAV---QKAAKAAPAANAAPAASPAATADAAKVKALE-DKIAQQAEKV 977
                     |.:::.::..|   .|.||.....:.|...: |:::|.:||:.:| .|.|...|:|
plant   674 VSGLVKYIPLEEMQNRMVCVLCNLKPAKMRDIVSQAMVLA-ASSSDGSKVELVEPPKTANIGERV 737

  Fly   978 RTLKATGD--------AAVWKPEVDILLSLKNELAALTGTPVAGGQG 1016
            ......|:        ..||:..:..|.:.:|.:|.....|.....|
plant   738 TFPGFEGEPDDVLNPKKKVWETLLVDLNTKENLVACYKDVPFTTSAG 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MetRS	NP_611382.1	GstA	1..175	CDD:223698
		GST_N_family	1..65	CDD:238319
		GST_C_family	63..164	CDD:295467
		PRK12268	254..812	CDD:237029	297/573 (52%)
		MetRS_core	255..625	CDD:173907	223/371 (60%)
		Anticodon_Ia_Met	634..763	CDD:153411	46/135 (34%)
		MetRS_RNA	828..868	CDD:238475	9/39 (23%)
		MetRS_RNA	895..938	CDD:238475	7/63 (11%)
		MetRS_RNA	966..1009	CDD:238475	11/51 (22%)
AT4G13780	NP_193114.1	PLN02610	1..797	CDD:215329	349/827 (42%)
		MetRS_core	18..388	CDD:173907	223/371 (60%)
		Anticodon_Ia_Met	397..530	CDD:153411	46/135 (34%)
		tRNA_bind_EMAP-II_like	634..738	CDD:239198	19/104 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	518	1.000	Domainoid score	I64
eggNOG	1	0.900	-	-		E1_COG0143
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	625	1.000	Inparanoid score	I203
OMA	1	1.010	-	-		QHG62211
OrthoDB	1	1.010	-	-		D333013at2759
OrthoFinder	1	1.000	-	-		FOG0004295
OrthoInspector	1	1.000	-	-		oto3629
orthoMCL	1	0.900	-	-		OOG6_101454
Panther	1	1.100	-	-	LDO	PTHR45765
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3028
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840