Protein Alignment MetRS and IleRS

DIOPT Version :10

• Sequence 1: NP_611382.1
• Gene: MetRS / 37177
• FlyBaseID: FBgn0034401
• Length: 1022
• Species: Drosophila melanogaster
• Sequence 2: NP_524840.2
• Gene: IleRS / 45785
• FlyBaseID: FBgn0027086
• Length: 1229
• Species: Drosophila melanogaster
• Alignment Length: 1027
• Identity: 195/1027 - (18%)
• Similarity: 323/1027 - (31%)
• Gaps: 364/1027 - (35%)

  Fly   196 VPLKRLSLADASKLLVDTTPTVADTVTNEEISAAKAAFTYTAPKEIKEERTVLPKPGERNVLITS 260
            |.|:.:||.:...|:..|||.   |:.:..........||...:::|.:|..:......:.:..|
  Fly   216 VALEAVSLPNTFFLVWTTTPW---TLPSNFACCVHPTMTYVKVRDVKSDRLFVLAESRLSYVYKS 277

  Fly   261 ALPYVNNVPHLGNIIGCVLSADIYARYSRSA----GYNTLLICGTDEYGTATENKALAENLTPRE 321
            ...|......:|..:..:....::..:::..    .|..|:    |||.|......:
  Fly   278 ETEYEVKEKFVGKTLKDLHYKPLFPYFAKRGAEVKAYRVLV----DEYVTEDSGTGI-------- 330

  Fly   322 ICDKYFELHNAIYRWFGIGFDYFGRTTTQEQTDIVQEAFKDVLKAGYIITESVEQLLCQKCDRFL 386
                   :|||         .|||           ::.::..|.|| :||:|.|.|    |....
  Fly   331 -------VHNA---------PYFG-----------EDDYRVCLAAG-LITKSSEVL----CPVDE 363

  Fly   387 ADRFVEGTCPHPGCGYEDARGDQCDK--------CGKLVNATELIR--PRCKVCNSAPVLRSSDQ 441
            |.||........|...:|:     ||        .|.||::.::..  |.|...::..:.::...
  Fly   364 AGRFTNEASDFEGQYVKDS-----DKQIMAALKARGNLVSSGQVKHSYPFCWRSDTPLIYKAVPS 423

  Fly   442 LFIDLPKAEPQLKE------WV-----DKSEGGWTHNAKVITRAWLKEGLKPRCITRDLKWGIPV 495
            .|:.:......|.:      ||     :|..|.|...|    |.|        .|:|:..||.|:
  Fly   424 WFVRVEHMSKNLLDCSSQTYWVPDFVKEKRFGNWLKEA----RDW--------AISRNRYWGTPI 476

  Fly   496 PHEGFEKKVFYVWFDAPFGYVSMTKRYTKEYQQWWQPAKGTDVELFQFMAKDNVPFHSVVWPSVL 560
            |          :| .:|.|..::.....|:..:    ..|..||.....:.|::...|.|
  Fly   477 P----------IW-RSPSGDETVVIGSIKQLAE----LSGVQVEDLHRESIDHIEIPSAV----- 521

  Fly   561 LAINKGHTLVSHIMATEYLNYEDGKFSKSRGIGVFGNDAQ-ETGIPADVWRFYLASARPEGQDSS 624
                .|:..:..|.......:|.|....::....|.|:.. ....|||    ::|    ||.|.:
  Fly   522 ----PGNPPLRRIAPVFDCWFESGSMPFAQQHFPFENEKDFMNNFPAD----FIA----EGIDQT 574

  Fly   625 FSWNDLAARNNSELLNN--LGNFVNRALVFC---------EKNFSSTVPGVITTQDELVLLALIN 678
            ..|.......::.|.|.  ..|.:...||..         :||:...:..|.....:.:.|.|||
  Fly   575 RGWFYTLLVISTALFNKAPFKNLIASGLVLAADGQKMSKRKKNYPDPMEVVHKYGADALRLYLIN 639

  Fly   679 RELRGYINSMEKAKLR---DGVRHLLA----------------ISRH------GNG-YMQSQQ-- 715
            ..:      :....||   :|||.::.                |.|:      ||| |...::
  Fly   640 SPV------VRAESLRFKEEGVRDIIKDVFLPWYNAYRFLLQNIVRYEKEDLAGNGQYTYDRERH 698

  Fly   716 -----------PWVL--------LKGTDDQKTRASTIIGLCVNIACLLANLLFPYMPTTARTLFG 761
                       .|:|        ...|:.:..|..|::.........|.|.   |:....|.:.|
  Fly   699 LKNMDKASVIDVWILSFKESLLEFFATEMKMYRLYTVVPRLTKFIDQLTNW---YVRLNRRRIKG 760

  Fly   762 QLNAKQ----------------------TPLNAEKPLVTLLL--PAGHQIGKPAPLFAKLEQSFI 802
            :|.|.|                      ||...|.....|:|  |||           .||.:
  Fly   761 ELGADQCIQSLDTLYDVLYTMVKMMAPFTPYLTEYIFQRLVLFQPAG-----------TLEHA-- 812

  Fly   803 DELKGKYGGAQATNDAAHSQISAA--------DLEKAV----------QAQADK--------VRE 841
                          |:.|.|:...        |:|::|          :...|:        |.|
  Fly   813 --------------DSVHYQMMPVSQKKFIRNDIERSVALMQSVVELGRVMRDRRTLPVKYPVSE 863

  Fly   842 LKASTKDKAI------WQPEVTKLLDLKK-QLEEAKKK--TATAAAP---AATPAPSNGSQSVQD 894
            :.|..||..|      .|..:...|:::| .|...|:|  ....|.|   |.........::|..
  Fly   864 IIAIHKDSQILEAIKTLQDFILSELNVRKLTLSSDKEKYGVTLRAEPDHKALGQRLKGNFKAVMA 928

  Fly   895 LEKAIQE--------QG-----------DKVR-------KLKGSTKDKTVWQPEVNILLDL---- 929
            ..||:::        ||           |:||       ::.|:.:..:  ..||.:|||:
  Fly   929 AIKALRDDEIQKQVSQGYFDILDQRIELDEVRIIYCTSEQVGGNFEAHS--DNEVLVLLDMTPNE 991

  Fly   930 --------KKQLEAVQKAAKAA--------------PAANAAPAASPAATADAAKV--------- 963
                    ::.:..|||..|.|              .|.|.|......|.|..|||
  Fly   992 ELLEEGLAREVINRVQKLKKKAQLIPTDPVLIFHELAADNKAKQEVLEAQAQLAKVLSNYASIIK 1056

  Fly   964 KALEDKIA----QQAEKVRTLKATGDAAVWKPEVDILLSLKNELAALTGTPV 1011
            .|::.:.|    :||.|.|.                   :.:||..|.|.|:
  Fly  1057 TAIKSEFAPYSSEQASKKRL-------------------IASELVDLKGVPL 1089

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MetRS	NP_611382.1	GST_N_5	1..70	CDD:436537
		GST_C_family	63..164	CDD:470672
		PLN02610	248..>850	CDD:215329	134/735 (18%)
		MetRS_RNA	895..938	CDD:238475	14/80 (18%)
		MetRS_RNA	966..1009	CDD:238475	8/46 (17%)
IleRS	NP_524840.2	PLN02882	9..1094	CDD:215477	195/1027 (19%)