Protein Alignment MetRS and ValRS

DIOPT Version :10

• Sequence 1: NP_611382.1
• Gene: MetRS / 37177
• FlyBaseID: FBgn0034401
• Length: 1022
• Species: Drosophila melanogaster
• Sequence 2: NP_001260946.1
• Gene: ValRS / 45783
• FlyBaseID: FBgn0027079
• Length: 1055
• Species: Drosophila melanogaster
• Alignment Length: 1103
• Identity: 205/1103 - (18%)
• Similarity: 319/1103 - (28%)
• Gaps: 460/1103 - (41%)

  Fly   224 EEISAAKAAFTYTAPKEIKEERTVL----------------------------------PKPGER 254
            :|:..|......|||.|.|:....|                                  |.|..:
  Fly    66 KEVKEAAVYTAQTAPGEKKDLSGALPDAYSPRYVEAQWYSWWEKEGFFTPEYGRASIDAPNPNGK 130

  Fly   255 NVLITSALPYVNNVPHLGNIIGCVLSADIYARYSRSAGYNTLLICGTDEYGTATE---NKAL--A 314
            .|:|... |.|....|||:.:...:. |...||.|..|..||.:.|.|..|.||:   .|.|  .
  Fly   131 FVMIIPP-PNVTGSLHLGHALTNAIE-DAITRYHRMKGRTTLWVPGCDHAGIATQVVVEKLLWRD 193

  Fly   315 ENLTPREI-CDKYFELHNAIYRW--------------FGIGFDY----------FGRTTTQ---- 350
            |.|:..:: .:|:.|   .|:.|              .|..:|:          ..|..|:
  Fly   194 EKLSRHDLGREKFIE---RIWDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVR 255

  Fly   351 --EQTDI------------VQEAFKDV---------------------------LKAGYIITESV 374
              |:..|            ::.|..|:                           :|..|.:..|.
  Fly   256 LHEEGSIYRSSRLVNWSCTLRSAISDIEVDKVEIPGRTFLSIPGYEDKVEFGVLIKFAYKVEGSD 320

  Fly   375 EQLLCQK-----------------------------------------CDRFLADRFVEG----T 394
            |:::...                                         ||.|:...|..|    |
  Fly   321 EEIIVATTRIETMLGDTAVAVHPQDDRYKHLHGKFVVHPFSTRRLPIVCDEFVDMAFGTGAVKIT 385

  Fly   395 CPHPGCGYEDARGDQCD--------------------------KCGKLV----NATELIRPRCKV 429
            ..|....||  .|.:|:                          :|.|.:    .|..|.|   :.
  Fly   386 PAHDPNDYE--VGKRCNLPFITIFNDDGYIIGDYGEFTGMKRFECRKKILEKLKALNLYR---ET 445

  Fly   430 CNSAPVL----RSSDQLFIDLPKAEPQLK-EW--------VDKSEGGWTHNAKVI----TRAWL- 476
            .|:..|:    ||.|.:       ||.:| :|        ...:|...:...|:|    |:.|.
  Fly   446 LNNPMVVPICSRSKDVV-------EPLIKPQWYVSCSDMAASATEAVRSGELKIIPEHHTKTWYH 503

  Fly   477 -KEGLKPRCITRDLKWG--IPVPHEGFEKKVFYVWFDAPFGYVSMTKRYTKEYQQWWQPAK---- 534
             .:|::..|::|.|.||  ||..|..|.        |......|.......:.:|:|..|:
  Fly   504 WMDGIRDWCVSRQLWWGHRIPAYHVSFT--------DPSLQTGSSAHGSVNDDEQYWIVARSEAE 560

  Fly   535 ---------GTDVELFQFMAKDNV----------PFHSVVWPS---------------------- 558
                     |.|.........::|          ||....||.
  Fly   561 ALTKAAERFGVDASKIVLKQDEDVLDTWFSSGIFPFSVFGWPDQTKDLQTFYPTSLLETGHDILF 625

  Fly   559 --VLLAINKGHTLVSHIMATE-YLN--YEDG---KFSKS-----------RGIGVFGNDAQ---- 600
              |...:..|..|:..:...| ||:  ..|.   |.|||           |||.:.|..||
  Fly   626 FWVARMVFFGQKLLGKLPFKEVYLHPMVRDAHGRKMSKSLGNVIDPMDVIRGITLEGLHAQLVGS 690

  Fly   601 ------------------ETGIP---ADVWRFYLASARPEGQDSSFSWNDLAARNNSELLNNLGN 644
                              ..|||   :|..||.|.:...:.:|.:..
  Fly   691 NLDPREIEKAKAGQKQDYPQGIPECGSDALRFALCAYITQARDINLD------------------ 737

  Fly   645 FVNRAL---VFCEKNFSST------VPGVITTQDELVLLALINRELRGYINSMEKAKLRDGVRHL 700
             :||.|   .||.|.:::|      ..|......||...|.|| ::..:|.|          |..
  Fly   738 -INRVLGYRFFCNKLWNATKFALLYFTGSEKFDTELSASAAIN-QMDAWILS----------RLA 790

  Fly   701 LAISRHGNG------------------------YMQSQQPWVLLKGTDDQKTRASTIIGLCVNIA 741
            .||.....|                        |::..:| :...|:::|:|.|...:.:|::..
  Fly   791 AAIEACNTGFESYDFAAATSACYAFWLYDLCDVYLECLKP-IFQSGSEEQQTAARRTLYVCLDYG 854

  Fly   742 CLLANLLFPYMPTTARTLFGQLNAKQTPLNAEKPLVTLLLPAGHQIGKPAPLFAKLEQSFIDELK 806
               ..||.|:||.....|:.:                  ||..:    |||....
  Fly   855 ---LRLLSPFMPFITEELYQR------------------LPRAN----PAPSICV---------- 884

  Fly   807 GKYGGAQATNDAAHSQISAADLE---KAVQ----AQADKVRELKASTKDKAIWQPEVTKLLDLKK 864
                .:..:|.:..|....:|:|   ||.:    |::|.....|..|:...:....|...: ||:
  Fly   885 ----ASYPSNTSWRSTKIESDVEFVQKAARIIRSARSDYNLPNKVKTEVYIVCTDSVPSEI-LKR 944

  Fly   865 QLEEAKKKTATAAAPAATPAPS-------NGSQSVQDLEKAIQEQGDKVRKLKGSTKDKTVWQPE 922
            ...:....:..:.....:|||.       .|...|..|.|.:.|...::.||:
  Fly   945 YASDLATISYCSNVVFDSPAPQGCAILTVTGQCEVHLLLKGLVEADKEIAKLQ------------ 997

  Fly   923 VNILLDLKKQLEAVQKAAKAAPAANAAPAAS--PAATADAAKVKALEDK--IAQQAEKVRTLK 981
                   ||..:.||...|...|..||..|:  ||...:|.:.|..|.:  |.:.|..:.|||
  Fly   998 -------KKSDQLVQTVGKLTQAIQAADYATKVPAEVQEANETKLCESRAEIERIAAAIETLK 1053

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MetRS	NP_611382.1	GST_N_5	1..70	CDD:436537
		GST_C_family	63..164	CDD:470672
		PLN02610	248..>850	CDD:215329	166/935 (18%)
		MetRS_RNA	895..938	CDD:238475	8/42 (19%)
		MetRS_RNA	966..1009	CDD:238475	6/18 (33%)
ValRS	NP_001260946.1	PTZ00419	80..1053	CDD:240411	199/1087 (18%)