Protein Alignment MetRS and MARS1

DIOPT Version :10

• Sequence 1: NP_611382.1
• Gene: MetRS / 37177
• FlyBaseID: FBgn0034401
• Length: 1022
• Species: Drosophila melanogaster
• Sequence 2: NP_004981.2
• Gene: MARS1 / 4141
• HGNCID: 6898
• Length: 900
• Species: Homo sapiens
• Alignment Length: 917
• Identity: 452/917 - (49%)
• Similarity: 589/917 - (64%)
• Gaps: 65/917 - (7%)

  Fly     1 MIIYTNDGNPLGLQLLMLAKFAKQPVQVQLVNLNDAKYKDLLV-------LPTLELDNGLRLFSP 58
            |.::.:||.|..|.:|..|..|:...:|.:..:..   :|.:|       :|.|:||:|..|||.
Human     1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGP---EDCVVPFLTRPKVPVLQLDSGNYLFST 62

  Fly    59 AAIAKYLFVGKGQQRD----EWLEWSATLLAPALA---HHMAVGHKADANALPVLNALVKKLDDK 116
            :||.:|.|:..|.::|    :||||.||.|.|||:   :::.|..|...:.|..:...:..:|..
Human    63 SAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHS 127

  Fly   117 L--KATPYLAGDKPSAADIAIWSLLAPDGTLKG----AQNVDNLRDWYGRVKALPEVQEVLAEQP 175
            |  :..|:|||:..|.|||.:|..|.|  .|:.    .:.:..|..|:         |.:..::|
Human   128 LSRQNCPFLAGETESLADIVLWGALYP--LLQDPAYLPEELSALHSWF---------QTLSTQEP 181

  Fly   176 LKDLSFNALQQSNRYGGLHHVPL--KRLSLADASKLLVDTTPTVAD--TVTNEEISAAKAAF--- 233
            .:..:...|:|.   |.|...|.  |:...:.|....|...|...:  |::.|||:.|..|:
Human   182 CQRAAETVLKQQ---GVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKG 243

  Fly   234 TYTAPKEIKEERTVLPKPGERNVLITSALPYVNNVPHLGNIIGCVLSADIYARYSRSAGYNTLLI 298
            ..:.|....::..|||..|||||||||||||||||||||||||||||||::|||||...:|||.:
Human   244 LESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYL 308

  Fly   299 CGTDEYGTATENKALAENLTPREICDKYFELHNAIYRWFGIGFDYFGRTTTQEQTDIVQEAFKDV 363
            |||||||||||.|||.|.|||:||||||..:|..|||||.|.||.||||||.:||.|.|:.|:.:
Human   309 CGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQL 373

  Fly   364 LKAGYIITESVEQLLCQKCDRFLADRFVEGTCPHPGCGYEDARGDQCDKCGKLVNATELIRPRCK 428
            ||.|:::.::||||.|:.|.||||||||||.||.  ||||:||||||||||||:||.||.:|:||
Human   374 LKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPF--CGYEEARGDQCDKCGKLINAVELKKPQCK 436

  Fly   429 VCNSAPVLRSSDQLFIDLPKAEPQLKEWVDKSEGG--WTHNAKVITRAWLKEGLKPRCITRDLKW 491
            ||.|.||::||..||:||||.|.:|:||:.::..|  ||.||:.|||:||::|||||||||||||
Human   437 VCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKW 501

  Fly   492 GIPVPHEGFEKKVFYVWFDAPFGYVSMTKRYTKEYQQWWQPAKGTDVELFQFMAKDNVPFHSVVW 556
            |.|||.||||.|||||||||..||:|:|..||.::::||:..:  .|:|:||||||||||||:|:
Human   502 GTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPE--QVDLYQFMAKDNVPFHSLVF 564

  Fly   557 PSVLLAINKGHTLVSHIMATEYLNYEDGKFSKSRGIGVFGNDAQETGIPADVWRFYLASARPEGQ 621
            |...|.....:|||||::|||||||||||||||||:||||:.||:||||||:|||||...|||||
Human   565 PCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQ 629

  Fly   622 DSSFSWNDLAARNNSELLNNLGNFVNRALVFCEKNFSSTVPGVITTQDELVLLALINRELRGYIN 686
            ||:|||.||..:||||||||||||:|||.:|..|.|...||.::.|.|:..|||.:..||:.|..
Human   630 DSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQ 694

  Fly   687 SMEKAKLRDGVRHLLAISRHGNGYMQSQQPWVLLKGTDDQKTRASTIIGLCVNIACLLANLLFPY 751
            .:||.::||.:|.:|.||||||.|:|..:||..:||::..:.||.|:.||.||||.||:.:|.||
Human   695 LLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPY 759

  Fly   752 MPTTARTLFGQLNAKQTPLNAEKPLVT---LLLPAGHQIGKPAPLFAKLEQSFIDELKGKYGGAQ 813
            |||.:.|:..||   |.|..|...|:|   ..||||||||..:|||.|||...|:.|:.::||.|
Human   760 MPTVSATIQAQL---QLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQ 821

  Fly   814 ATNDAAHSQISAADLEKAVQAQA---------DKVRELKASTKDKAIWQPEVTKLLDLKKQLEEA 869
            |......:.:......|..|.||         :.||||||...||.....||.|||||||||..|
Human   822 AKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVA 886

  Fly   870 KKKTATA 876
            :.|...|
Human   887 EGKPPEA 893

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MetRS	NP_611382.1	GST_N_5	1..70	CDD:436537	23/75 (31%)
		GST_C_family	63..164	CDD:470672	33/113 (29%)
		PLN02610	248..>850	CDD:215329	364/615 (59%)
		MetRS_RNA	895..938	CDD:238475
		MetRS_RNA	966..1009	CDD:238475
MARS1	NP_004981.2	GST_N_5	1..74	CDD:436537	23/75 (31%)
		GST_C_MetRS_N	77..179	CDD:198340	31/112 (28%)
		PLN02610	251..893	CDD:215329	379/648 (58%)
		'HIGH' region	273..283		9/9 (100%)
		'KMSKS' region	593..597		3/3 (100%)