DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MetRS and TyrRS

DIOPT Version :9

Sequence 1:	NP_611382.1	Gene:	MetRS / 37177	FlyBaseID:	FBgn0034401	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	NP_648895.1	Gene:	TyrRS / 39829	FlyBaseID:	FBgn0027080	Length:	525	Species:	Drosophila melanogaster

Alignment Length:	432	Identity:	95/432 - (21%)
Similarity:	158/432 - (36%)	Gaps:	131/432 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   666 TTQDELVLLALINRELRGYINS-----------MEKAKLRDGVR-----HLLAISRHGNGYMQSQ 714
            |..|:.:...|..|:|:.|..:           :..:|:.|.::     .:|....|  .|:.:.
  Fly    20 TLGDDKLTKILAERDLKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLH--AYLDNM 82

  Fly   715 Q-PWVLLKGTDDQKTR--ASTIIGLCVNIACLLANLLF----PYMPTTARTL-FGQLNAKQTPLN 771
            : ||.||    :.:|:  ...|..:..:|...|..|.|    .|..:...|| ..:|::..|..:
  Fly    83 KAPWSLL----ELRTKYYEQVIKAMLSSIGVPLEKLKFVKGSDYQLSKEYTLDVYKLSSVVTQHD 143

  Fly   772 AEK-----------PLVTLLLPAGHQIGKPAPLFAKLEQSFIDELKGKYGGAQATNDAAHSQ--I 823
            |:|           ||::.||..|.|         .|::.:: ::..::||.........|:  :
  Fly   144 AKKAGAEVVKQVEYPLLSGLLYPGLQ---------ALDEEYL-KVDAQFGGVDQRKIFTFSEKYL 198

  Fly   824 SAADLEKAVQAQADKV-----RELKASTKDKAIWQPEVTKLLD----LKKQLEEAKKKTATAAAP 879
            .....||.:......|     .::.:|.:|..|      .|||    :||:|::|..:....|
  Fly   199 PQLGYEKRIHFMNPMVPGLAGGKMSSSEEDSKI------DLLDSPANVKKKLKKAFCEPGNIA-- 255

  Fly   880 AATPAPSNGSQS--------------------------------VQDLEKAIQEQGDKVRKLKGS 912
                  .||..|                                .:||||...|.     ||...
  Fly   256 ------DNGLLSFVKHVLFSLFKEGEGFEVNREAEHGGDVTFLKYEDLEKYYAED-----KLHPG 309

  Fly   913 TKDKTVWQPEVNILLD-LKKQLE--AVQKAAKAA--PAANAAPAASPAATADAAKVKALEDKIAQ 972
            ....|| :..:|.||| ::|..|  .:||.:.||  |.|.....|:|||.||......|:.::.:
  Fly   310 DLKATV-EKYINRLLDPIRKAFENPELQKLSAAAYPPPAKVKAGAAPAAGADEDAPHRLDIRVGK 373

  Fly   973 QAEKVRTLKATGDAAVWKPEVDILLSLKNELA-ALTGTPVAG 1013
            ..|..|           .|:.|.|..||.:|| |...|.::|
  Fly   374 VVEVAR-----------HPDADTLYVLKIDLAEAQPRTIISG 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MetRS	NP_611382.1	GstA	1..175	CDD:223698
		GST_N_family	1..65	CDD:238319
		GST_C_family	63..164	CDD:295467
		PRK12268	254..812	CDD:237029	36/180 (20%)
		MetRS_core	255..625	CDD:173907
		Anticodon_Ia_Met	634..763	CDD:153411	24/120 (20%)
		MetRS_RNA	828..868	CDD:238475	12/48 (25%)
		MetRS_RNA	895..938	CDD:238475	14/45 (31%)
		MetRS_RNA	966..1009	CDD:238475	11/43 (26%)
TyrRS	NP_648895.1	nt_trans	8..334	CDD:294020	70/349 (20%)
		tyrS	12..332	CDD:272976	69/347 (20%)
		tRNA_bind_EMAP-II_like	364..466	CDD:239198	13/52 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0143
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900