DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MetRS and mars1

DIOPT Version :9

Sequence 1:	NP_611382.1	Gene:	MetRS / 37177	FlyBaseID:	FBgn0034401	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	NP_956370.1	Gene:	mars1 / 338183	ZFINID:	ZDB-GENE-030219-83	Length:	922	Species:	Danio rerio

Alignment Length:	933	Identity:	431/933 - (46%)
Similarity:	596/933 - (63%)	Gaps:	82/933 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIIYTNDGNPLGLQLLMLAKFAKQPVQVQLVNLND--AKYKDLLVLPTLELDNGLRLFSPAAIAK 63
            |.::..:|||..|::|...:.:....:.|||...:  ..|....|||.|:|.:|..||||.:|.:
Zfish     1 MKLFIGEGNPHCLKVLAALELSGVRCETQLVKHEEKVVPYLTHPVLPILQLPSGQHLFSPNSICQ 65

  Fly    64 YLFVGKGQQ----RDEWLEWSATLLAPALAHHMAV----GHKADANALPVLNALVKKLDDKL--K 118
            |||...||:    .::||||.||.|.||:...:.:    |.:.:|.|  |:...:..|:..|  :
Zfish    66 YLFDVSGQKATDATNQWLEWEATNLQPAVLQSLQLVALQGKRVEAAA--VMKEPLSWLEQSLSKR 128

  Fly   119 ATPYLAGDKPSAADIAIWSLLAP---DGTLKGAQNVDNLRDWYGRVKALPEVQEVLAEQPLKDLS 180
            .|.:|..:..|.||:.:|:.|.|   |...:.. ::..:|.|:.||.::...|.. |.:.|:...
Zfish   129 KTSFLTDEVVSVADVVLWAALYPLLSDSAFEPG-DLQAVRGWFERVCSVSACQSA-ALRVLQGKG 191

  Fly   181 FNALQQSNRYGGLHHVPLKRLSLADASKLLVDTTPTVADT---VTNEEISAAKAAFT-----YTA 237
            ..||:...:...:.|.| :|.|.:::::        ..|:   ::.|||..|...::     :|.
Zfish   192 AEALKSFLQKQPVTHTP-RRDSPSNSTE--------AEDSERELSPEEIEEAAQVYSEGLKDFTV 247

  Fly   238 PKEIKEERTVLPKPGERNVLITSALPYVNNVPHLGNIIGCVLSADIYARYSRSAGYNTLLICGTD 302
            ..|.|  ..|||:.|:|||||||||||||||||||||||||||||::|||.|..|:|.|.|||||
Zfish   248 VTERK--HPVLPQEGKRNVLITSALPYVNNVPHLGNIIGCVLSADVFARYGRLRGWNLLYICGTD 310

  Fly   303 EYGTATENKALAENLTPREICDKYFELHNAIYRWFGIGFDYFGRTTTQEQTDIVQEAFKDVLKAG 367
            ||||||||||..|.|||::|||||..:|.:||:||.|.||:|||||||.||:|.|:.|..:.:.|
Zfish   311 EYGTATENKAREEGLTPQQICDKYHCIHASIYQWFQIDFDFFGRTTTQHQTEIAQDIFWRLHERG 375

  Fly   368 YIITESVEQLLCQKCDRFLADRFVEGTCPHPGCGYEDARGDQCDKCGKLVNATELIRPRCKVCNS 432
            :::.::||||.|:.|.||||||||||.|||  |.:.:||||||||||:|:||.||..|:||||..
Zfish   376 FLLEDTVEQLRCEGCQRFLADRFVEGECPH--CRFPEARGDQCDKCGRLINAVELKNPQCKVCKE 438

  Fly   433 APVLRSSDQLFIDLPKAEPQLKEWVDKS--EGGWTHNAKVITRAWLKEGLKPRCITRDLKWGIPV 495
            .||:|||..||::|||.|..|::|:..|  .|.||.||:.|||:||::||||||||||||||.||
Zfish   439 TPVIRSSKHLFLNLPKLEQDLEQWLQTSTAAGDWTTNARHITRSWLRDGLKPRCITRDLKWGTPV 503

  Fly   496 PHEGFEKKVFYVWFDAPFGYVSMTKRYTKEYQQWWQPAKGTDVELFQFMAKDNVPFHSVVWPSVL 560
            ||..:::||||||||||.||:|:|..||.::::||:..:  .|||:.|||||||||||||:|..|
Zfish   504 PHPDYKEKVFYVWFDAPIGYLSITANYTDQWERWWKNPQ--QVELYNFMAKDNVPFHSVVFPCSL 566

  Fly   561 LAINKGHTLVSHIMATEYLNYEDGKFSKSRGIGVFGNDAQETGIPADVWRFYLASARPEGQDSSF 625
            |.....:|||::::|||||||||.|||||||:||||:.|::||||:|||||||...|||||||:|
Zfish   567 LGAQDNYTLVNNLIATEYLNYEDTKFSKSRGVGVFGDMAKDTGIPSDVWRFYLLYLRPEGQDSAF 631

  Fly   626 SWNDLAARNNSELLNNLGNFVNRALVFCEKNFSSTVPGVITTQDELVLLALINRELRGYINSMEK 690
            ||.|:|.:||||||||||||:|||.:|..|.|...||.::...|:..|:|.:..||:.||..::|
Zfish   632 SWTDMALKNNSELLNNLGNFINRAGMFVSKFFDGCVPEMLLNDDDKRLIAQVCWELKQYIQLLDK 696

  Fly   691 AKLRDGVRHLLAISRHGNGYMQSQQPWVLLKGTDDQKTRASTIIGLCVNIACLLANLLFPYMPTT 755
            .::||.::.:|.:|||||.|:|..:||..:||..:.:.||.|:.|:.||:|||||.:|.|:|||.
Zfish   697 VRIRDALKCILNMSRHGNQYIQLNEPWKKIKGGAEDRCRAGTVTGVSVNVACLLAAVLEPFMPTV 761

  Fly   756 ARTLFGQLNAKQTPLNAEKPLVT------LLLPAGHQIGKPAPLFAKLEQSFIDELKGKYGGAQA 814
            :.::..||   |.|.::.:.:::      ..|||||:||..:|||.|||...|:.|:.::||.|.
Zfish   762 SLSIRSQL---QAPESSSRAMLSGPGAFICTLPAGHRIGTVSPLFQKLENEQIEALRKRFGGLQP 823

  Fly   815 TNDAA----------------------HSQIS-AADLEKA------VQAQADKVRELKASTKDKA 850
            ..::|                      |:..| .||.|:|      |..|.:|||.|||...:|:
Zfish   824 EEESAGLKTPSNSSVAVESKPNAGAAQHTPASVTADPERAKQLTALVAEQGEKVRALKAQKAEKS 888

  Fly   851 IWQPEVTKLLDLKKQLEEAKKKT 873
            ....||.||||||.||..|:.||
Zfish   889 AIGVEVAKLLDLKNQLCLAEGKT 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MetRS	NP_611382.1	GstA	1..175	CDD:223698	56/188 (30%)
		GST_N_family	1..65	CDD:238319	21/65 (32%)
		GST_C_family	63..164	CDD:295467	33/113 (29%)
		PRK12268	254..812	CDD:237029	325/565 (58%)
		MetRS_core	255..625	CDD:173907	241/371 (65%)
		Anticodon_Ia_Met	634..763	CDD:153411	58/128 (45%)
		MetRS_RNA	828..868	CDD:238475	21/45 (47%)
		MetRS_RNA	895..938	CDD:238475
		MetRS_RNA	966..1009	CDD:238475
mars1	NP_956370.1	GstA	1..173	CDD:223698	52/174 (30%)
		GST_N_family	1..67	CDD:238319	21/65 (32%)
		GST_C_MetRS_N	75..176	CDD:198340	28/103 (27%)
		PRK12268	261..820	CDD:237029	324/565 (57%)
		MetRS_core	263..631	CDD:173907	241/371 (65%)
		Anticodon_Ia_Met	640..769	CDD:153411	58/128 (45%)
		MetRS_RNA	866..910	CDD:238475	20/43 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596123
Domainoid	1	1.000	565	1.000	Domainoid score	I228
eggNOG	1	0.900	-	-		E1_COG0143
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H90878
Inparanoid	1	1.050	775	1.000	Inparanoid score	I516
OMA	1	1.010	-	-		QHG62211
OrthoDB	1	1.010	-	-		D279987at33208
OrthoFinder	1	1.000	-	-		FOG0004295
OrthoInspector	1	1.000	-	-		oto39201
orthoMCL	1	0.900	-	-		OOG6_101454
Panther	1	1.100	-	-	LDO	PTHR45765
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1449
SonicParanoid	1	1.000	-	-		X3028
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800