Protein Alignment MetRS and LeuRS

DIOPT Version :10

• Sequence 1: NP_611382.1
• Gene: MetRS / 37177
• FlyBaseID: FBgn0034401
• Length: 1022
• Species: Drosophila melanogaster
• Sequence 2: NP_787968.1
• Gene: LeuRS / 326262
• FlyBaseID: FBgn0284253
• Length: 1182
• Species: Drosophila melanogaster
• Alignment Length: 1203
• Identity: 216/1203 - (17%)
• Similarity: 382/1203 - (31%)
• Gaps: 471/1203 - (39%)

  Fly    22 AKQPVQV-QLVNLNDAKYKDLLVLPTLELDNGLRLFSPAAIAKYLFVGKGQQRDEWLEWSATLLA 85
            ||...|: |.:.|.|.:.||.     ...::.|..|.|.|:.....:|      ..::|..|.:.
  Fly   155 AKYQWQIMQSLGLKDEEIKDF-----ANAEHWLNYFPPLAVQDLKRIG------VHVDWRRTFIT 208

  Fly    86 PALAHHMAVGHKADANALPVLNALVKKLDDKLK------------------ATPYLAGDKPSAAD 132
                        .|||  |..::.|:...:.||                  ..|.:..|:.|...
  Fly   209 ------------TDAN--PYFDSFVRWQFNHLKERGKIMYGKRYTIYSPKDGQPCMDHDRSSGEG 259

  Fly   133 IA---------------------------IWSLLAPDGTLKGAQNV--------------DNLRD 156
            :.                           :.:.|.|: |:.|..|.              .|...
  Fly   260 VGPQEYTLIKMKVLEVPKALSSIKQPIFMVAATLRPE-TMYGQTNCWLHPDIKYIAWQANKNNEV 323

  Fly   157 WY------------------GRVKALPEV--QEVLA---EQPLKDLSFNALQQSNRYGGLHHVPL 198
            |.                  |.:|.|.||  |::|.   ..||           .::..::.:|:
  Fly   324 WVSTRRAARNMTYQGFTAVEGEIKVLAEVTGQDLLGVPLSAPL-----------TKHKVVYSLPM 377

  Fly   199 KRLSLADASKLLVDTTPTVADTVTNEEISAAKAAFTYTAPKEIKEERTVLPKPGERNVLITSALP 263
              ||:.:      |....|..:|.::      :...|.|..:::::.....|.|.::.::   ||
  Fly   378 --LSIKE------DKGTGVVTSVPSD------SPDDYAALVDLQKKEAFRQKYGLKDEMV---LP 425

  Fly   264 Y----VNNVPHLGNIIGCVLSADIYARYSRSAGYNTLLICGTDEYGTATENKALAENLTPREICD 324
            |    :..||.||.     ||| ::|       |.||.|      .:..:...|||   .:|:|
  Fly   426 YEPIPIIEVPTLGK-----LSA-VHA-------YETLKI------QSQNDKDKLAE---AKEMC- 467

  Fly   325 KYFELHNAIYRWFGIGFDYFGRTTTQEQTDIVQEAFKDVLKAGY-------IITESVEQLLCQKC 382
             |.:   :.|....:...:.||.....:.|: |:...|..:|..       |::.|.::.:...|
  Fly   468 -YLK---SFYDGVMLVGAFAGRKIQDVKKDL-QKRLVDANEADVYYEPEKTIMSRSADECVVALC 527

  Fly   383 DRFL-----------ADRFVEGTCPHPGCGYEDARGDQCDKCGKLVNATELIRPRCKVCNSAPVL 436
            :::.           |.:.:.|.    ...:|:|| :..:.|...::.        ..|:....|
  Fly   528 NQWYLNYGEPEWQAQATKILHGM----ETFHEEAR-NNFEACLNWLHE--------YACSRTYGL 579

  Fly   437 RSSDQLFIDLPKAEPQLKEWVDKSEGGWTHNAKVITRAWLKE----------------------- 478
            .:.      ||        |.||               ||.|
  Fly   580 GTK------LP--------WDDK---------------WLIESLSDSTIYMAFYTVVHLLQGGTF 615

  Fly   479 --------GLKPRCITRDLKWGIPVPHEGFEKKVFYVWF-DAPFGYVSMTKR-----YTKEYQQW 529
                    |:||..:|.:: |.             |::| :.|....:..|:     ..:|::.|
  Fly   616 RGEKPGPFGIKPSDMTGEI-WD-------------YIFFKETPLPKKTAIKQEHLAVLRREFEYW 666

  Fly   530 WQ---PAKGTDVELFQFMAKDNVPF----HSVVWPSVLLAINKGHTLVSHIMATEYLNYEDGKFS 587
            :.   ...|.|      :.::::.|    |:.:||:......||..:..|::    ||  ..|.|
  Fly   667 YPMDLRVSGKD------LIQNHLTFCLYNHAAIWPNDENKWPKGMRVNGHLL----LN--SAKMS 719

  Fly   588 KSRGIGVFGNDAQETGIPADVWRFYLASARPEGQDSSFSWNDLAARNNSELLNNLGNFVNRALVF 652
            ||.|..:...:|.:. ..||..|..||.|....:|::|          .|...:.|  :.|...|
  Fly   720 KSDGNFLTLTEAVDK-FSADGMRLCLADAGDSVEDANF----------VESTADAG--ILRLYTF 771

  Fly   653 CE------KNFSSTVPGVITTQDELVLLALINRELR----GYINSMEKAKLRDGVRHL-LAISRH 706
            .|      :|.||...|...|.::.|.|:.:|.:.:    .|...:.|..||.|...| ||..::
  Fly   772 IEWVKEMLENRSSLRKGTDKTFNDQVFLSELNLKTQQTDENYRKMLFKEALRSGFYELQLARDKY 836

  Fly   707 -----GNGYMQSQQPWVLLKGTDDQKTRASTIIGLCVNIACLLANLLFPYMPTTARTLFGQLNAK 766
                 .||..:.                      |.:......|.|:.|..|..|..::|.|..|
  Fly   837 RELCGANGMHED----------------------LVLEFIRRQALLVSPICPHMAEHVWGLLGNK 879

  Fly   767 QTPLNAEKPLV-----------TLLLPAGH------------------------QIGKP------ 790
            ::.::|..|.|           ..|:.|.|                        |..||
  Fly   880 ESIVHARWPEVGAINEVDILCSEYLMEAAHSFRLNLKNLLQIKGKAGKDKSVNVQAAKPNRGLVW 944

  Fly   791 -APLFAKLEQSFIDELKGKYGGAQATNDAAHSQISAADLE---------KAVQAQADKVRELKAS 845
             |..:...:...:|.:|..:..:||..|   :::.||.|:         |.|...|..:||...|
  Fly   945 VAKTYPPWQCCVLDTMKELFNKSQALPD---NKVIAATLQQKAELKKFMKRVMPFAQMIREKVES 1006

  Fly   846 TKDKAIW---------QPEVTKLLDLKKQLE------------EAKKKTATAAAPAA-----TPA 884
            .|..|..         |..::.|..||..|:            .|.:||.....|.:     :.|
  Fly  1007 GKGVAALAVTLEFDERQVLISNLEYLKNTLDLDVLEIKYTDDPSAPEKTREEVRPGSPFISFSVA 1071

  Fly   885 PSNGSQSVQDLEKA--------------IQEQGDKVRKLKGSTKDKT---VWQ------------ 920
            |:...:....:|::              :|...:|:.|:.|...|..   :|:
  Fly  1072 PNVSVELTNPIERSSLFQVNTVISEGDTVQSLREKLSKIIGLKTDAATLKIWRYEDPVLGPRKIP 1136

  Fly   921 ------------PEVNILLDLKKQLEAVQKAAK 941
                        .|.|.:||::.:..::::|.|
  Fly  1137 NFEDYKAGKSVLGEGNFVLDVENKKVSLEQAGK 1169

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MetRS	NP_611382.1	GST_N_5	1..70	CDD:436537	13/48 (27%)
		GST_C_family	63..164	CDD:470672	22/177 (12%)
		PLN02610	248..>850	CDD:215329	142/734 (19%)
		MetRS_RNA	895..938	CDD:238475	11/83 (13%)
		MetRS_RNA	966..1009	CDD:238475
LeuRS	NP_787968.1	PLN02959	1..1068	CDD:215518	201/1100 (18%)