DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MetRS and rar1

DIOPT Version :9

Sequence 1:	NP_611382.1	Gene:	MetRS / 37177	FlyBaseID:	FBgn0034401	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	NP_595586.1	Gene:	rar1 / 2540052	PomBaseID:	SPBC17A3.04c	Length:	782	Species:	Schizosaccharomyces pombe

Alignment Length:	803	Identity:	332/803 - (41%)
Similarity:	457/803 - (56%)	Gaps:	110/803 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 NGLRLFSPAAIAKYL--------FVGKGQQRDEW----------LEWSATLLAPALAHHMAVGHK 97
            |.:||.:.....||:        |:...|:.|.:          |:|.|....|..  :.|...:
pombe    44 NSVRLVNSKEPEKYVSDANAIVSFLYWKQEEDLFNSFISSKLSILDWEALQFTPKA--YTAKTKE 106

  Fly    98 ADANALPVLNALVKKLDDKLKATPYLAGDKPSAADIAIWSLLAPDGTLKGA--QNVDNLRDWYGR 160
            ..|..|..|..:.|:.:...:.||.   :...|:||...       .|.||  :....|..||.:
pombe   107 DFAYLLSQLETIFKENEILNEFTPV---EVALASDIYFC-------VLNGAPVREYPLLSAWYLK 161

  Fly   161 V-KALPEVQEVLAEQPLKDLSFNALQQSNRYGGLHHVPLKRLSLADASKLLVDTT---PTVADTV 221
            : |..|.||                                     |.||..:.|   |.|..|
pombe   162 IEKQKPFVQ-------------------------------------ALKLTFEKTLGQPAVTST- 188

  Fly   222 TNEEISAAKAAFTYTAPKEIKEE---RTVLPKPGERNVLITSALPYVNNVPHLGNIIGCVLSADI 283
              |:|..::......:...::|.   ..:|||..|||:||||||||||||||||||:|..||||:
pombe   189 --EKIPVSETTRNVNSQHLMRERVPGEKILPKSNERNILITSALPYVNNVPHLGNIVGSTLSADV 251

  Fly   284 YARYSRSAGYNTLLICGTDEYGTATENKALAENLTPREICDKYFELHNAIYRWFGIGFDYFGRTT 348
            :|||.|:..:|||.||||||||||||.|||.|.::|:|:||||..||..:|.||.|.||:|||||
pombe   252 FARYHRARNHNTLYICGTDEYGTATETKALEEGVSPKELCDKYHALHKEVYDWFEIDFDHFGRTT 316

  Fly   349 TQEQTDIVQEAFKDVLKAGYIITESVEQLLCQKCDRFLADRFVEGTCPHPGCGYEDARGDQCDKC 413
            |.:||.|.|..|..:....|:..:::.||.|:....:||||:||||||.  |||:||||||||.|
pombe   317 TPKQTGIAQHIFTKLYNNDYMAIDTMTQLYCEVHQGYLADRYVEGTCPK--CGYDDARGDQCDGC 379

  Fly   414 GKLVNATELIRPRCKVCNSAPVLRSSDQLFIDLPKAEPQLKEWVDKS--EGGWTHNAKVITRAWL 476
            |.|:||.|||.|:||:..:.||.|.:..:|:.|.|.:|.::.|..:|  ||.|::|.:.||.:||
pombe   380 GGLLNAFELIDPKCKLDRATPVKRETKHVFLSLDKLQPAVESWAMQSAVEGKWSNNGRSITESWL 444

  Fly   477 KEGLKPRCITRDLKWGIPVPHEGFEKKVFYVWFDAPFGYVSMTKRYTKEYQQWWQPAKGTDVELF 541
            ||||:|||||||||||.|||.|.|:.||.||||||..||:|:|..||.|:::||:..:  .|:|:
pombe   445 KEGLRPRCITRDLKWGTPVPLEEFKGKVLYVWFDATIGYISITANYTDEWEKWWRNPE--QVKLY 507

  Fly   542 QFMAKDNVPFHSVVWPSVLLAINKGHTLVSHIMATEYLNYEDGKFSKSRGIGVFGNDAQETGIPA 606
            |||.|||||||:|::||.||...:..|::.||..|:|||||.||||||||:|||||.||:.|:..
pombe   508 QFMGKDNVPFHTVIFPSSLLGTGEKWTMLHHINTTDYLNYETGKFSKSRGVGVFGNTAQDIGLSP 572

  Fly   607 DVWRFYLASARPEGQDSSFSWNDLAARNNSELLNNLGNFVNRALVFCEKNFSSTVPGVITTQDEL 671
            .|||:||.|:|||..|:.|:|.:...|:|||||.||||||||.|.|....::..||..:|  |..
pombe   573 SVWRYYLLSSRPETSDTMFTWKEFITRHNSELLANLGNFVNRTLKFTTAKYNGLVPHYLT--DPS 635

  Fly   672 V--------LLALINRELRGYINSMEKAKLRDGVRHLLAISRHGNGYMQSQQPWVLLKGTDD--- 725
            |        .:..:|..|..|..::|.:|||:|:|..:.||..||.|:|..:       .|:
pombe   636 VGAGKLKADFVKDVNALLAKYNAALEASKLREGLRLAMEISARGNQYLQDNR-------IDNKCY 693

  Fly   726 --QKTRASTIIGLCVNIACLLANLLFPYMPTTARTLFGQLNAKQTPLNAEKPLVTLLLPAGHQIG 788
              ::.:.:..||..:|:..|||.:.:||||:|:.:::.||||   |..|......|.|..||:||
pombe   694 LYERQKCADAIGYALNLIYLLAAIFYPYMPSTSTSIYKQLNA---PAAAIPDTWELCLLPGHRIG 755

  Fly   789 KPAPLFAKLEQSFIDELKGKYGG 811
            :|..||.::::|..:|.:.||||
pombe   756 EPEYLFTRIDESMEEEWRSKYGG 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MetRS	NP_611382.1	GstA	1..175	CDD:223698	32/144 (22%)
		GST_N_family	1..65	CDD:238319	4/13 (31%)
		GST_C_family	63..164	CDD:295467	26/121 (21%)
		PRK12268	254..812	CDD:237029	286/573 (50%)
		MetRS_core	255..625	CDD:173907	214/371 (58%)
		Anticodon_Ia_Met	634..763	CDD:153411	47/141 (33%)
		MetRS_RNA	828..868	CDD:238475
		MetRS_RNA	895..938	CDD:238475
		MetRS_RNA	966..1009	CDD:238475
rar1	NP_595586.1	PRK12268	222..779	CDD:237029	286/573 (50%)
		MetRS_core	223..591	CDD:173907	214/371 (58%)
		Anticodon_Ia_Met	600..733	CDD:153411	47/141 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	493	1.000	Domainoid score	I59
eggNOG	1	0.900	-	-		E1_COG0143
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H90878
Inparanoid	1	1.050	586	1.000	Inparanoid score	I164
OMA	1	1.010	-	-		QHG62211
OrthoFinder	1	1.000	-	-		FOG0004295
OrthoInspector	1	1.000	-	-		oto102143
orthoMCL	1	0.900	-	-		OOG6_101454
Panther	1	1.100	-	-	LDO	PTHR45765
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1449
SonicParanoid	1	1.000	-	-		X3028
TreeFam	1	0.960	-	-
	14	13.860