Protein Alignment MetRS and Mars1

DIOPT Version :10

• Sequence 1: NP_611382.1
• Gene: MetRS / 37177
• FlyBaseID: FBgn0034401
• Length: 1022
• Species: Drosophila melanogaster
• Sequence 2: NP_001165053.1
• Gene: Mars1 / 216443
• MGIID: 1345633
• Length: 910
• Species: Mus musculus
• Alignment Length: 979
• Identity: 453/979 - (46%)
• Similarity: 601/979 - (61%)
• Gaps: 132/979 - (13%)

  Fly     1 MIIYTNDGNPLGLQLLMLAKFAKQPVQVQLVNLNDAKYKDLLV-------LPTLELDNGLRLFSP 58
            |.::.::|:|..|.:|..|..|:...::.:..:..   ::.:|       :|.|:||:|..|||.
Mouse     1 MRLFVSEGSPGSLPVLAAAARARGRAELLISTVGP---EECVVPFLTRPKVPVLQLDSGNYLFSA 62

  Fly    59 AAIAKYLFVGKGQQRD----EWLEWSATLLAPALA---HHMAVGHKADANALPVLNALVKKLDDK 116
            :||.:|.|:..|.::|    :||||.||.|.|.|:   |.:.|..|...:.|..|..::..:|..
Mouse    63 SAICRYFFLLCGWEQDDLTNQWLEWEATELQPVLSAALHCLVVQGKKGEDILGPLRRVLTHIDHS 127

  Fly   117 L--KATPYLAGDKPSAADIAIWSLLAPDGTLKG----AQNVDNLRDWYGRVKALPEVQEVLAEQP 175
            |  :..|:||||..|.|||.:|..|.|  .|:.    .:.:..|:.|:         |.:..::|
Mouse   128 LSRQNCPFLAGDTESLADIVLWGALYP--LLQDPAYLPEELGALQSWF---------QTLSTQEP 181

  Fly   176 LKDLSFNALQQSNRYGGLHHVPLKRLSLADASKLLVDTTP----------TVAD--------TVT 222
            .:..:...|:|.   |.|            |.:|.:...|          ||::        |::
Mouse   182 CQRAAETVLKQQ---GVL------------ALRLYLQKQPQPQPPPPEGRTVSNELEEEELATLS 231

  Fly   223 NEEISAAKAAF---TYTAPKEIKEERTVLPKPGERNVLITSALPYVNNVPHLGNIIGCVLSADIY 284
            .|:|..|.||:   ..:.|....::..|||.||||||||||||||||||||||||||||||||::
Mouse   232 EEDIVTAVAAWEKGLESLPPLKLQQHPVLPVPGERNVLITSALPYVNNVPHLGNIIGCVLSADVF 296

  Fly   285 ARYSRSAGYNTLLICGTDEYGTATENKALAENLTPREICDKYFELHNAIYRWFGIGFDYFGRTTT 349
            |||.|...:|||.:|||||||||||.||:.|.||||||||||..:|..|||||||.||.||||||
Mouse   297 ARYCRLRQWNTLYLCGTDEYGTATETKAMEEGLTPREICDKYHAIHADIYRWFGISFDTFGRTTT 361

  Fly   350 QEQTDIVQEAFKDVLKAGYIITESVEQLLCQKCDRFLADRFVEGTCPHPGCGYEDARGDQCDKCG 414
            .:||.|.|:.|:.:|..|:::.::||||.|::|.||||||||||.||.  ||||:|||||||:||
Mouse   362 PQQTKITQDIFQRLLTRGFVLRDTVEQLRCERCARFLADRFVEGVCPF--CGYEEARGDQCDRCG 424

  Fly   415 KLVNATELIRPRCKVCNSAPVLRSSDQLFIDLPKAEPQLKEWVDKSEGG--WTHNAKVITRAWLK 477
            ||:||.||.:|:||:|.|.||:|||..||:||||.|.:|::|:.|:..|  ||.||:.|.|:||:
Mouse   425 KLINAIELKKPQCKICRSCPVVRSSQHLFLDLPKLEKRLEDWLGKTVPGSDWTPNARFIIRSWLR 489

  Fly   478 EGLKPRCITRDLKWGIPVPHEGFEKKVFYVWFDAPFGYVSMTKRYTKEYQQWWQPAKGTDVELFQ 542
            :||||||||||||||.|||.||||.|||||||||..||||:|..||.::::||:..:  .|:|:|
Mouse   490 DGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYVSITANYTDQWEKWWKNPE--QVDLYQ 552

  Fly   543 FMAKDNVPFHSVVWPSVLLAINKGHTLVSHIMATEYLNYEDGKFSKSRGIGVFGNDAQETGIPAD 607
            ||||||||||.:|:|..:|.....:|||.||:||||||||||||||||||||||:.|::||||||
Mouse   553 FMAKDNVPFHGLVFPCSVLGAEDNYTLVKHIIATEYLNYEDGKFSKSRGIGVFGDMAKDTGIPAD 617

  Fly   608 VWRFYLASARPEGQDSSFSWNDLAARNNSELLNNLGNFVNRALVFCEKNFSSTVPGVITTQDELV 672
            :|||||...|||||||:|||.||..:||||||||||||:|||.:|..|.|...||.:..|.|:..
Mouse   618 IWRFYLLYIRPEGQDSAFSWTDLLIKNNSELLNNLGNFINRAGMFVSKFFGGCVPEMALTPDDRR 682

  Fly   673 LLALINRELRGYINSMEKAKLRDGVRHLLAISRHGNGYMQSQQPWVLLKGTDDQKTRASTIIGLC 737
            |:|.::.||:.|...:||.::||.:|.:|.||||||.|:|..:||..:||.:..:.||.|:.|:.
Mouse   683 LVAHVSWELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGGEMDRQRAGTVTGMA 747

  Fly   738 VNIACLLANLLFPYMPTTARTLFGQLNAKQTPLNAEKPLVT---LLLPAGHQIGKPAPLFAKLEQ 799
            ||:|.||:.:|.|||||.:.|:..||   |.|..|.:.|.|   ..|||||:||..:|||.|||.
Mouse   748 VNMAALLSVMLQPYMPTVSSTIQTQL---QLPPAACRILATSFICTLPAGHRIGTVSPLFQKLEN 809

  Fly   800 SFIDELKGKYGGAQATNDAAHSQISAADLEKAVQAQADKVRELKASTKDKAIWQPEVTKLLDLKK 864
            ..|:.|:.::||.|              ||:::        ||||....|
Mouse   810 DQIENLRQRFGGGQ--------------LEESL--------ELKAKGSPK--------------- 837

  Fly   865 QLEEAKKKTATAAAPAATPAPSNGSQSVQDLEKAIQEQGDKVRKLKGSTKDKTVWQPEVNILLDL 929
                      .||..|.|.|   |||.:|.|...:.:||:.||:||....||.....||..||||
Mouse   838 ----------PAAVEAVTAA---GSQHIQTLTDEVTKQGNVVRELKAQKADKNQVAAEVAKLLDL 889

  Fly   930 KKQL 933
            ||||
Mouse   890 KKQL 893

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MetRS	NP_611382.1	GST_N_5	1..70	CDD:436537	20/75 (27%)
		GST_C_family	63..164	CDD:470672	35/113 (31%)
		PLN02610	248..>850	CDD:215329	352/606 (58%)
		MetRS_RNA	895..938	CDD:238475	19/39 (49%)
		MetRS_RNA	966..1009	CDD:238475
Mars1	NP_001165053.1	GST_N_5	1..74	CDD:436537	20/75 (27%)
		GST_C_MetRS_N	77..179	CDD:198340	33/112 (29%)
		PLN02610	258..>848	CDD:215329	359/646 (56%)
		'HIGH' region	275..285		9/9 (100%)
		'KMSKS' region	595..599		3/3 (100%)
		MetRS_RNA	855..899	CDD:238475	19/39 (49%)