Protein Alignment MetRS and Mars2

DIOPT Version :10

• Sequence 1: NP_611382.1
• Gene: MetRS / 37177
• FlyBaseID: FBgn0034401
• Length: 1022
• Species: Drosophila melanogaster
• Sequence 2: NP_780648.1
• Gene: Mars2 / 212679
• MGIID: 2444136
• Length: 586
• Species: Mus musculus
• Alignment Length: 599
• Identity: 147/599 - (24%)
• Similarity: 231/599 - (38%)
• Gaps: 106/599 - (17%)

  Fly   252 GERNVLITSALPYVNNVPHLGNIIGCVLSADIYARYSR---SAGYNTLLICGTDEYGTATENKAL 313
            ||.....|:.:.|||..||:|::...:| ||...|:.|   ....:|....||||:|...:..|.
Mouse    34 GEARAYFTTPIFYVNAAPHIGHLYSALL-ADALCRHRRLRVPGSASTRFSTGTDEHGLKIQQAAA 97

  Fly   314 AENLTPREICDKYFELHNAIYRWFGIGFDYFGRTTTQEQTDIVQEAFKDVLKAGYIITESV-EQL 377
            ...|.|.|:||:.......::|...|....|.|||.......||. |..||:|..::.:.: |..
Mouse    98 TAGLAPIELCDRVSAQFLQLFREADISSTDFIRTTEARHRVAVQH-FWGVLEARGLLYKGIYEGW 161

  Fly   378 LCQKCDRFLADRFVEGTCPHPGCGYEDARGDQCDKCGKLVNATELIRPRCKVC-----NSAPVLR 437
            .|...:.||.:                            ...|..:.|....|     :..||..
Mouse   162 YCASDECFLPE----------------------------AKVTRQVGPSGDPCPVSLESGHPVSW 198

  Fly   438 SSDQLFI-DLPKAEPQLKEWVDKSEGGWT----HNAKVITRAWLKEGLKPRCITR---DLKWGIP 494
            :.::.:| .|.:....|:.|:..:....|    |.|.:   .||:|.|....::|   .|.||||
Mouse   199 TKEENYIFKLSQFREPLQRWLGNNPQAITPEPFHQAVL---QWLEEELPDLSVSRRSSHLHWGIP 260

  Fly   495 VPHEGFEKKVFYVWFDAPFGYVSMTKRYTKEYQQWWQPAKGTDVELFQFMAKDNVPFHSVVWPSV 559
            ||  |.:.:..|||.||...|:::......:::.|| ||..      ..:.||.:.||::.||::
Mouse   261 VP--GDDSQTIYVWLDALVNYLTVVGYPDADFKSWW-PATS------HIIGKDILKFHAIYWPAL 316

  Fly   560 LL--AINKGHTLVSHIMATEYLNYEDGKFSKSRGIGVFGNDAQETGIPADVWRFYLASARPEGQD 622
            ||  .:...|.:..|    .:......|.|||.|..|......:. ...|.:|::|........|
Mouse   317 LLGAGLRPPHRIYVH----SHWTVSGQKMSKSLGNVVDPRTCLDR-YTVDGFRYFLLRQGVPNWD 376

  Fly   623 SSFSWNDLAARNNSELLNNLGNFVNRALV-----------FCEKNFSS----TVPGVITTQDELV 672
            ..:....:....:|||.:.||..:||...           ||...|.|    |.|.|....::..
Mouse   377 CDYYDEKVVKLLDSELADALGGLLNRCTAYRINPSGTYPSFCAACFPSEPGLTGPSVRVQAEDYA 441

  Fly   673 L---LALINRELRGYINSMEKAKLRDGVRHLLAISRHGNGYMQSQQPWVLLKGTDDQKTRASTII 734
            |   :|.:.:.:.||.|..:..|..:.|...:   |..||::|...||.|...:.:......|::
Mouse   442 LVTAVATLPKLVAGYYNDFQIYKALEAVSSCV---RQTNGFVQRHAPWKLNWESPEDAPWLGTVL 503

  Fly   735 GLCVNIACLLANLLFPYMPTTARTLFGQLNAKQTPLNAEKPLVTL-LLPAGHQIGKPAP------ 792
            .:.:....:...||.|..|..|..|..:|....|    |:.|..| .||..:  |.|.|
Mouse   504 HVALECLRVFGTLLQPVTPNLADKLLSRLGVSTT----ERGLGELYFLPRFY--GHPCPFEGRKL 562

  Fly   793 ------LFAKLEQS 800
                  ||.:|:||
Mouse   563 GPDTGLLFPRLDQS 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MetRS	NP_611382.1	GST_N_5	1..70	CDD:436537
		GST_C_family	63..164	CDD:470672
		PLN02610	248..>850	CDD:215329	147/599 (25%)
		MetRS_RNA	895..938	CDD:238475
		MetRS_RNA	966..1009	CDD:238475
Mars2	NP_780648.1	MetG	37..574	CDD:439913	142/592 (24%)
		'HIGH' region	45..55		5/9 (56%)
		'KMSKS' region	340..344		2/3 (67%)