DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MetRS and mars-1

DIOPT Version :9

Sequence 1:	NP_611382.1	Gene:	MetRS / 37177	FlyBaseID:	FBgn0034401	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	NP_001255570.1	Gene:	mars-1 / 178089	WormBaseID:	WBGene00003415	Length:	917	Species:	Caenorhabditis elegans

Alignment Length:	795	Identity:	353/795 - (44%)
Similarity:	485/795 - (61%)	Gaps:	66/795 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 EISAAKAAFTYTAP--KEIKEERTVLPKPGERNVLITSALPYVNNVPHLGNIIGCVLSADIYARY 287
            :::..|.:|..:.|  .|.|:.:::||:||:||:|||:||||||||||||||||||||||::|||
Worm     4 DLADIKKSFEASLPGYVEKKDPKSILPQPGKRNILITAALPYVNNVPHLGNIIGCVLSADVFARY 68

  Fly   288 SRSAGYNTLLICGTDEYGTATENKALAENLTPREICDKYFELHNAIYRWFGIGFDYFGRTTTQEQ 352
            ....|:.|..:.||||||||||.|||.|..||||:||||..:|..||.||||.|.:||||||..|
Worm    69 CNLRGHQTFYVGGTDEYGTATETKALQEGCTPRELCDKYHAIHKGIYEWFGIDFSHFGRTTTDHQ 133

  Fly   353 TDIVQEAFKDVLKAGYIITESVEQLLCQKCDRFLADRFVEGTCPHPGCGYEDARGDQCDKCGKLV 417
            |:|.|:.|..:.|.||..::||:||.|.:|::|||||||.||||.  |.|:||||||||.||||:
Worm   134 TEICQDMFLKLHKNGYTSSQSVDQLYCNQCEKFLADRFVTGTCPM--CAYDDARGDQCDGCGKLI 196

  Fly   418 NATELIRPRCKVCNSAPVLRSSDQLFIDLPKAEPQLKEWVD----KSEGGWTHNAKVITRAWLKE 478
            ||.:|...:|.:|.:.|.::.|..:|:.|.|.:.:..|.:|    |.:..|:.||..||:||:|.
Worm   197 NAVDLKDAKCHMCKATPEVKQSTHIFLSLDKLQQKTTEHLDRELAKEDNRWSSNAVGITKAWMKL 261

  Fly   479 GLKPRCITRDLKWGIPVPHEGFEKKVFYVWFDAPFGYVSMTK-----RYTKEYQQWWQPAKGTDV 538
            ||.|||||||||||..||.:||||||||||||||.||:|:||     .:||    ||:..:  :|
Worm   262 GLDPRCITRDLKWGTAVPLDGFEKKVFYVWFDAPIGYLSITKCVLGDNWTK----WWKNPE--NV 320

  Fly   539 ELFQFMAKDNVPFHSVVWPSVLLAINKGHTLVSHIMATEYLNYEDGKFSKSRGIGVFGNDAQETG 603
            |||.|:.||||.||:|::|...|..|..:|:|:::.|||||||||.|||||||.|:||:.||.|.
Worm   321 ELFNFVGKDNVAFHAVMFPCSQLGANDNYTVVNNLCATEYLNYEDTKFSKSRGTGIFGDAAQGTE 385

  Fly   604 IPADVWRFYLASARPEGQDSSFSWNDLAARNNSELLNNLGNFVNRALVFCEKNFSSTVPGVITTQ 668
            ||||:|||||...|||.||::|||:|...:.|||||||||||:||||.|...:|...||.:..|.
Worm   386 IPADIWRFYLLYMRPESQDTAFSWDDFVLKVNSELLNNLGNFINRALSFVANSFGGVVPEMNLTN 450

  Fly   669 DELVLLALINRELRGYINSMEKAKLRDGVRHLLAISRHGNGYMQSQQPWVLLKGTDDQKTRASTI 733
            |:..:|:.|:.|...:....:...|:|.|:.:|.:||.||.|||:|.||||:|..::.|.||.||
Worm   451 DDAEVLSEIHNECMQWDKQFDGVHLKDAVKTILNVSRLGNQYMQAQTPWVLMKKDEEGKKRAGTI 515

  Fly   734 IGLCVNIACLLANLLFPYMPTTARTLFGQLNAKQTPLNAEKPLVTLLLPAGHQIGKPAPLFAKLE 798
            ||:..|||..::.||:|.|||.:.|:..|......||....|:  ..|.|||:||:|:|||.||:
Worm   516 IGVAANIAYHVSVLLYPIMPTISATIREQCGLPALPLFTPFPI--CYLKAGHKIGQPSPLFQKLD 578

  Fly   799 QSFIDELKGKYGGAQATNDAAHSQISAADLEKAVQAQADKVRELK--ASTKDKAIWQPEVTKLLD 861
            .:.|.|.|.|:||:|             |.:.:....|:|.::.|  |.||||
Worm   579 PAQIAEFKAKFGGSQ-------------DAQSSAPKTAEKPKQQKKQAPTKDK------------ 618

  Fly   862 LKKQLEEAKKKTATAAAPAATPAPSNGSQSV-QDLEKAIQEQG----DKVRKLKGSTKDKTVWQP 921
                 :..||..:|||...........||.: |:|:|..|.:.    :::::|.|..|..|:
Worm   619 -----KGDKKMASTAAFVELEQGAKVISQLIAQNLKKFDQAKALFTRNQLQRLDGENKQLTI--- 675

  Fly   922 EVNILLDLKKQLE---AVQKAAKAAPAANAAPAASPAA--TADAAKVKALEDKIAQQAEKVRTLK 981
            :|..|.....:||   .:::..|...:....|.::||:  ..:|.|.:|.......:.:|.:..|
Worm   676 DVKTLQHQLIELETAAGIKQVPKPVVSCTPTPTSTPASGIITEAPKKEAPSTPAPSEPKKAKEQK 740

  Fly   982 ATGDAAVWKPEVDIL 996
            .....|...|..|.:
Worm   741 KGKGGAAAAPVDDTI 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MetRS	NP_611382.1	GstA	1..175	CDD:223698
		GST_N_family	1..65	CDD:238319
		GST_C_family	63..164	CDD:295467
		PRK12268	254..812	CDD:237029	302/566 (53%)
		MetRS_core	255..625	CDD:173907	218/378 (58%)
		Anticodon_Ia_Met	634..763	CDD:153411	58/128 (45%)
		MetRS_RNA	828..868	CDD:238475	8/41 (20%)
		MetRS_RNA	895..938	CDD:238475	11/49 (22%)
		MetRS_RNA	966..1009	CDD:238475	5/31 (16%)
mars-1	NP_001255570.1	PLN02610	21..898	CDD:215329	350/778 (45%)
		MetRS_core	36..407	CDD:173907	218/378 (58%)
		Anticodon_Ia_Met	416..544	CDD:153411	58/127 (46%)
		tRNA_bind_EMAP-II_like	755..857	CDD:239198	0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167391
Domainoid	1	1.000	492	1.000	Domainoid score	I181
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	641	1.000	Inparanoid score	I443
Isobase	1	0.950	-	0	Normalized mean entropy	S822
OMA	1	1.010	-	-		QHG62211
OrthoDB	1	1.010	-	-		D279987at33208
OrthoFinder	1	1.000	-	-		FOG0004295
OrthoInspector	1	1.000	-	-		oto19858
orthoMCL	1	0.900	-	-		OOG6_101454
Panther	1	1.100	-	-	LDO	PTHR45765
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1449
SonicParanoid	1	1.000	-	-		X3028
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.890