Protein Alignment MetRS and mars-1

DIOPT Version :10

• Sequence 1: NP_611382.1
• Gene: MetRS / 37177
• FlyBaseID: FBgn0034401
• Length: 1022
• Species: Drosophila melanogaster
• Sequence 2: NP_001255570.1
• Gene: mars-1 / 178089
• WormBaseID: WBGene00003415
• Length: 917
• Species: Caenorhabditis elegans
• Alignment Length: 795
• Identity: 353/795 - (44%)
• Similarity: 485/795 - (61%)
• Gaps: 66/795 - (8%)

  Fly   225 EISAAKAAFTYTAP--KEIKEERTVLPKPGERNVLITSALPYVNNVPHLGNIIGCVLSADIYARY 287
            :::..|.:|..:.|  .|.|:.:::||:||:||:|||:||||||||||||||||||||||::|||
 Worm     4 DLADIKKSFEASLPGYVEKKDPKSILPQPGKRNILITAALPYVNNVPHLGNIIGCVLSADVFARY 68

  Fly   288 SRSAGYNTLLICGTDEYGTATENKALAENLTPREICDKYFELHNAIYRWFGIGFDYFGRTTTQEQ 352
            ....|:.|..:.||||||||||.|||.|..||||:||||..:|..||.||||.|.:||||||..|
 Worm    69 CNLRGHQTFYVGGTDEYGTATETKALQEGCTPRELCDKYHAIHKGIYEWFGIDFSHFGRTTTDHQ 133

  Fly   353 TDIVQEAFKDVLKAGYIITESVEQLLCQKCDRFLADRFVEGTCPHPGCGYEDARGDQCDKCGKLV 417
            |:|.|:.|..:.|.||..::||:||.|.:|::|||||||.||||.  |.|:||||||||.||||:
 Worm   134 TEICQDMFLKLHKNGYTSSQSVDQLYCNQCEKFLADRFVTGTCPM--CAYDDARGDQCDGCGKLI 196

  Fly   418 NATELIRPRCKVCNSAPVLRSSDQLFIDLPKAEPQLKEWVD----KSEGGWTHNAKVITRAWLKE 478
            ||.:|...:|.:|.:.|.::.|..:|:.|.|.:.:..|.:|    |.:..|:.||..||:||:|.
 Worm   197 NAVDLKDAKCHMCKATPEVKQSTHIFLSLDKLQQKTTEHLDRELAKEDNRWSSNAVGITKAWMKL 261

  Fly   479 GLKPRCITRDLKWGIPVPHEGFEKKVFYVWFDAPFGYVSMTK-----RYTKEYQQWWQPAKGTDV 538
            ||.|||||||||||..||.:||||||||||||||.||:|:||     .:||    ||:..:  :|
 Worm   262 GLDPRCITRDLKWGTAVPLDGFEKKVFYVWFDAPIGYLSITKCVLGDNWTK----WWKNPE--NV 320

  Fly   539 ELFQFMAKDNVPFHSVVWPSVLLAINKGHTLVSHIMATEYLNYEDGKFSKSRGIGVFGNDAQETG 603
            |||.|:.||||.||:|::|...|..|..:|:|:::.|||||||||.|||||||.|:||:.||.|.
 Worm   321 ELFNFVGKDNVAFHAVMFPCSQLGANDNYTVVNNLCATEYLNYEDTKFSKSRGTGIFGDAAQGTE 385

  Fly   604 IPADVWRFYLASARPEGQDSSFSWNDLAARNNSELLNNLGNFVNRALVFCEKNFSSTVPGVITTQ 668
            ||||:|||||...|||.||::|||:|...:.|||||||||||:||||.|...:|...||.:..|.
 Worm   386 IPADIWRFYLLYMRPESQDTAFSWDDFVLKVNSELLNNLGNFINRALSFVANSFGGVVPEMNLTN 450

  Fly   669 DELVLLALINRELRGYINSMEKAKLRDGVRHLLAISRHGNGYMQSQQPWVLLKGTDDQKTRASTI 733
            |:..:|:.|:.|...:....:...|:|.|:.:|.:||.||.|||:|.||||:|..::.|.||.||
 Worm   451 DDAEVLSEIHNECMQWDKQFDGVHLKDAVKTILNVSRLGNQYMQAQTPWVLMKKDEEGKKRAGTI 515

  Fly   734 IGLCVNIACLLANLLFPYMPTTARTLFGQLNAKQTPLNAEKPLVTLLLPAGHQIGKPAPLFAKLE 798
            ||:..|||..::.||:|.|||.:.|:..|......||....|:  ..|.|||:||:|:|||.||:
 Worm   516 IGVAANIAYHVSVLLYPIMPTISATIREQCGLPALPLFTPFPI--CYLKAGHKIGQPSPLFQKLD 578

  Fly   799 QSFIDELKGKYGGAQATNDAAHSQISAADLEKAVQAQADKVRELK--ASTKDKAIWQPEVTKLLD 861
            .:.|.|.|.|:||:|             |.:.:....|:|.::.|  |.||||
 Worm   579 PAQIAEFKAKFGGSQ-------------DAQSSAPKTAEKPKQQKKQAPTKDK------------ 618

  Fly   862 LKKQLEEAKKKTATAAAPAATPAPSNGSQSV-QDLEKAIQEQG----DKVRKLKGSTKDKTVWQP 921
                 :..||..:|||...........||.: |:|:|..|.:.    :::::|.|..|..|:
 Worm   619 -----KGDKKMASTAAFVELEQGAKVISQLIAQNLKKFDQAKALFTRNQLQRLDGENKQLTI--- 675

  Fly   922 EVNILLDLKKQLE---AVQKAAKAAPAANAAPAASPAA--TADAAKVKALEDKIAQQAEKVRTLK 981
            :|..|.....:||   .:::..|...:....|.::||:  ..:|.|.:|.......:.:|.:..|
 Worm   676 DVKTLQHQLIELETAAGIKQVPKPVVSCTPTPTSTPASGIITEAPKKEAPSTPAPSEPKKAKEQK 740

  Fly   982 ATGDAAVWKPEVDIL 996
            .....|...|..|.:
 Worm   741 KGKGGAAAAPVDDTI 755

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MetRS	NP_611382.1	GST_N_5	1..70	CDD:436537
		GST_C_family	63..164	CDD:470672
		PLN02610	248..>850	CDD:215329	316/612 (52%)
		MetRS_RNA	895..938	CDD:238475	11/49 (22%)
		MetRS_RNA	966..1009	CDD:238475	5/31 (16%)
mars-1	NP_001255570.1	PLN02610	21..898	CDD:215329	350/778 (45%)