DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MetRS and Aimp1

DIOPT Version :9

Sequence 1:	NP_611382.1	Gene:	MetRS / 37177	FlyBaseID:	FBgn0034401	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	NP_031952.2	Gene:	Aimp1 / 13722	MGIID:	102774	Length:	319	Species:	Mus musculus

Alignment Length:	277	Identity:	59/277 - (21%)
Similarity:	102/277 - (36%)	Gaps:	99/277 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   808 KYGGAQATNDAAHSQISAADLEKAVQAQADKVRE-LK---ASTKDKAIWQP---EVTKL----LD 861
            ::.|..|||||...::.    :|.  |:||::.| ||   |..|:|||.|.   |..||    ..
Mouse     5 RFWGKMATNDAVLKRLE----QKG--AEADQIIEYLKQQVALLKEKAILQATMREEKKLRVENAK 63

  Fly   862 LKKQLEEAKKK-------------------------TAT-----AAAPAATPAPSNGSQSVQDLE 896
            |||::||.|::                         ||:     :.:.|.|.:|:...|.....|
Mouse    64 LKKEIEELKQELILAEIHNGVEQVRVRLSTPLQTNCTASESVVQSPSVATTASPATKEQIKAGEE 128

  Fly   897 KAIQEQGDKVRKLKGSTKDK-------TVWQP--------EVNILLDLKKQLEAVQKAAKAAPAA 946
            |.::|:.:|    ||..|:|       |..:|        .:..::..||..:|.....:.....
Mouse   129 KKVKEKTEK----KGEKKEKQQSAAASTDSKPIDASRLDLRIGCIVTAKKHPDADSLYVEEVDVG 189

  Fly   947 NAAPAASPAATADAAKVKALEDKI-----------------------AQQAEKVRTL-------- 980
            .|||....:...:...::.:::::                       |...|||..|
Mouse   190 EAAPRTVVSGLVNHVPLEQMQNRMVVLLCNLKPAKMRGVLSQAMVMCASSPEKVEILAPPNGSVP 254

  Fly   981 --KATGDAAVWKPEVDI 995
              :.|.||...:|:.::
Mouse   255 GDRITFDAFPGEPDKEL 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MetRS	NP_611382.1	GstA	1..175	CDD:223698
		GST_N_family	1..65	CDD:238319
		GST_C_family	63..164	CDD:295467
		PRK12268	254..812	CDD:237029	0/3 (0%)
		MetRS_core	255..625	CDD:173907
		Anticodon_Ia_Met	634..763	CDD:153411
		MetRS_RNA	828..868	CDD:238475	19/50 (38%)
		MetRS_RNA	895..938	CDD:238475	13/57 (23%)
		MetRS_RNA	966..1009	CDD:238475	9/63 (14%)
Aimp1	NP_031952.2	NUDE_C	17..>117	CDD:282704	26/105 (25%)
Aimp1	NP_031952.2	tRNA_bind_EMAP-II_like	157..259	CDD:239198	11/101 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0143
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900