DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MetRS and Yars

DIOPT Version :9

Sequence 1:	NP_611382.1	Gene:	MetRS / 37177	FlyBaseID:	FBgn0034401	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	NP_598912.5	Gene:	Yars / 107271	MGIID:	2147627	Length:	528	Species:	Mus musculus

Alignment Length:	353	Identity:	72/353 - (20%)
Similarity:	127/353 - (35%)	Gaps:	100/353 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   708 NGYMQSQQ-PWVLL----------------------------KGTDDQKTRASTIIGLCVNIACL 743
            :.|:.:.: ||.||                            ||||.|.::..|
Mouse    77 HAYLDNMKAPWELLELRTSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYT----------- 130

  Fly   744 LANLLFPYMPTTARTLFGQLNAK----QTPLNAEKPLVTLLLPAGHQIGKPAPLFAKLEQSFIDE 804
                |..|..::..|   |.:||    :.....|.||::.||..|.|         .|::.:: :
Mouse   131 ----LDVYRLSSVVT---QHDAKKAGAEVVKQVEHPLLSGLLYPGLQ---------ALDEEYL-K 178

  Fly   805 LKGKYGGAQATN--DAAHSQISAADLEKAVQAQADKVRELKASTKDKAIWQPEVTKLLDLKKQLE 867
            :..::||.....  ..|...:.|....|.|......|..|..|....:    |....:||..:.|
Mouse   179 VDAQFGGVDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSS----EEESKIDLLDRKE 239

  Fly   868 EAKKKTATAAAPAATPAPSNGSQS-VQDLEKAIQEQGDKVRKLK-GSTKDKTVW-------QPEV 923
            :.|||...|...... ..:||..| ::.:...::.:...:|..| |..|..||:       ..||
Mouse   240 DVKKKLKKAFCEPGN-VENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTVYLELEKDFAAEV 303

  Fly   924 NILLDLKKQLE-----------------AVQKAAKAA---PAANAAPAASPAATADAAKVKALED 968
            ....|||..:|                 |::|.|.||   |:....||..||..::..:|  :..
Mouse   304 VHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPPAKGPAKNSEPEEV--IPS 366

  Fly   969 KIAQQAEKVRTLKATGDA-AVWKPEVDI 995
            ::..:..|:.:::...|| :::..::|:
Mouse   367 RLDIRVGKILSVEKHPDADSLYVEKIDV 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MetRS	NP_611382.1	GstA	1..175	CDD:223698
		GST_N_family	1..65	CDD:238319
		GST_C_family	63..164	CDD:295467
		PRK12268	254..812	CDD:237029	26/136 (19%)
		MetRS_core	255..625	CDD:173907
		Anticodon_Ia_Met	634..763	CDD:153411	14/83 (17%)
		MetRS_RNA	828..868	CDD:238475	8/39 (21%)
		MetRS_RNA	895..938	CDD:238475	13/67 (19%)
		MetRS_RNA	966..1009	CDD:238475	4/31 (13%)
Yars	NP_598912.5	nt_trans	8..328	CDD:350862	57/283 (20%)
		'HIGH' region	44..52
		'KMSKS' region	222..226		0/3 (0%)
		PLN02610	<327..528	CDD:215329	15/70 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	339..363		7/23 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0143
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900