Protein Alignment Cyp12b2 and Cyp27b1

DIOPT Version :10

• Sequence 1: NP_611370.2
• Gene: Cyp12b2 / 37163
• FlyBaseID: FBgn0034387
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_034139.2
• Gene: Cyp27b1 / 13115
• MGIID: 1098274
• Length: 507
• Species: Mus musculus
• Alignment Length: 489
• Identity: 141/489 - (28%)
• Similarity: 225/489 - (46%)
• Gaps: 46/489 - (9%)

  Fly    51 RSFGEIPGPSLLRMLSFFMPGGALRNTNLIQMNRLMREMYGDIYCIPGMMGKPNAVFTYNPDDFE 115
            ||..:|||||.|..|:.....|.|...:.:|::...|  ||.|:  .|..|....|:..:|...|
Mouse    35 RSLSDIPGPSTLSFLAELFCKGGLSRLHELQVHGAAR--YGPIW--SGSFGTLRTVYVADPTLVE 95

  Fly   116 MTYRNEGVWPIRIGLESLNYYRKIHRPDVFKGVGGLASDQGQEWADIRNKVNPVLMKVQNVRQNL 180
            ...|.|...|.|....|...:|:.|:    :..|.|.:| |:||..:|:.:.|:|::.|......
Mouse    96 QLLRQESHCPERCSFSSWAEHRRRHQ----RACGLLTAD-GEEWQRLRSLLAPLLLRPQAAAGYA 155

  Fly   181 PQLDQISKEFIDKLETQRNPETHT--LTTDFHNQLKMWAFESISFVALNTRMGLLSDNPDPNADR 243
            ..||.:.::.:.:|..||...:..  |..|...:...:..|||..|.|.:|:|.|.....|:.:.
Mouse   156 GTLDNVVRDLVRRLRRQRGRGSGLPGLVLDVAGEFYKFGLESIGAVLLGSRLGCLEAEVPPDTET 220

  Fly   244 LAKHMRDFFNYSFQFDVQPSIWTFYKTAG-FKKFLKTYDNITDITSNYI-----ETAMRGFGK-N 301
            ....:...|..:......|: |..:...| :.:..:.:|.:......::     |.|||..|| .
Mouse   221 FIHAVGSVFVSTLLTMAMPN-WLHHLIPGPWARLCRDWDQMFAFAQRHVELREGEAAMRNQGKPE 284

  Fly   302 DDGKTKCVLEQLLEHNKKVAVTMVM----DMLMAGIDTTSSACLTILYHLARNPSKQEKLRRELL 362
            :|..:...|...| ..:||:|..::    ::|:||:||.|:.....||.|:|:|..|..|..|
Mouse   285 EDMPSGHHLTHFL-FREKVSVQSIVGNVTELLLAGVDTVSNTLSWTLYELSRHPDVQTALHSE-- 346

  Fly   363 RILPTTKDSLTDQN---TKNMPYLRACIKEGLRITSITPGNFRITPKDLVLSGYQVPRGTGVLMG 424
             |...|:.|....:   ...:|.|:|.|||.||:..:.|||.|:..:|:.:..|.:|:.|.|.:.
Mouse   347 -ITAGTRGSCAHPHGTALSQLPLLKAVIKEVLRLYPVVPGNSRVPDRDIRVGNYVIPQDTLVSLC 410

  Fly   425 VLELSNDDKYFAQSSEFIPERWLKSDLAPDIQACPAARTRNPFVYLPFGFGPRTCIGKRIAELEI 489
            ....|.|...|...:.|.|.|||.....|           :||..||||||.|:|||:|:||||:
Mouse   411 HYATSRDPTQFPDPNSFNPARWLGEGPTP-----------HPFASLPFGFGKRSCIGRRLAELEL 464

  Fly   490 ETLLVRLLRSYKVSWLPE---TPIEYESTIILSP 520
            :..|.::|..::|  |||   .||:..:..:|.|
Mouse   465 QMALSQILTHFEV--LPEPGALPIKPMTRTVLVP 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12b2	NP_611370.2	CYP24A1-like	87..525	CDD:410677	129/453 (28%)
Cyp27b1	NP_034139.2	CYP27B1	68..502	CDD:410741	129/456 (28%)