Protein Alignment Cyp12b2 and cyp27a1

DIOPT Version :10

• Sequence 1: NP_611370.2
• Gene: Cyp12b2 / 37163
• FlyBaseID: FBgn0034387
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: XP_002933986.3
• Gene: cyp27a1 / 100145331
• XenbaseID: XB-GENE-984298
• Length: 557
• Species: Xenopus tropicalis
• Alignment Length: 518
• Identity: 144/518 - (27%)
• Similarity: 252/518 - (48%)
• Gaps: 60/518 - (11%)

  Fly    27 GGTLSQQTQLELADSRIDEKWQQARSFGEIPGPSLLRMLSFFMPGGALRNTNLIQMNRLMREMYG 91
            |.::||...:..|.....|..::.:.|.::||||||:.|.::...|.|.:|:.:|:  :.::|||
 Frog    60 GASVSQGRAVTGAAVGATEGRKEMKEFEDLPGPSLLKNLYYYFLRGYLLHTHELQL--IYKKMYG 122

  Fly    92 DIYCIPGMMGKPNAVFTYNPDDFEMTYRNEGVWPIRIGLESLNYYRKIHRPDVFKGVGGLASDQG 156
            .::  ...:||...|...:|:..:...|.||.:|:|    :.....|.|| |..|...|..:::|
 Frog   123 PLW--RSEIGKYKMVNIADPEVLQRLVRQEGKYPMR----NKEDVWKAHR-DKRKLAYGPFTEEG 180

  Fly   157 QEWADIRNKVNPVLMKVQNVRQNLPQLDQISKEFIDKLETQRNPE-THTLTTDFHNQLKMWAFES 220
            .:|..||:.:|..::|..........::::..:|:|:|:..|... :..:..|..|.|..:|||.
 Frog   181 HQWYQIRSALNKKMLKPSEAASYAGGINEVVTDFMDRLQDMRKASPSGDMVNDLANALYRFAFEG 245

  Fly   221 ISFVALNTRMGLLSDNPDPNADRLAKHMRDFFNYSFQFDVQPSI---WTFYKTAGFKKFLKTYDN 282
            ||.:...||:|.|.....|...:..    |...|.|:..|..:.   ||......:..:::.:||
 Frog   246 ISNIVFETRIGCLDKQIPPETQKFI----DSIGYMFKNSVYVTFLPHWTRGILPYWDHYIEGWDN 306

  Fly   283 ITDITSNYIETAMRGFGKNDDGKTKCVLEQLLEHNKKVA------------VTM------VMDML 329
            |.|            |||:...|....::..|:..::|.            :||      |.::|
 Frog   307 IFD------------FGKHLIDKKMSEIQSRLDKGEEVEGEYLTYLLSSANLTMGEVYGSVCELL 359

  Fly   330 MAGIDTTSSACLTILYHLARNPSKQEKLRRELLRILPTTKDSLTDQNTKNMPYLRACIKEGLRIT 394
            :||:||||:.....:|||||:|..|:.:..|:....|..:..:. ::..|||.||..|||.||:.
 Frog   360 LAGVDTTSNTLCWAMYHLARDPELQQAVYEEVSSAAPMDRIPVA-EDIPNMPLLRGVIKETLRLY 423

  Fly   395 SITPGNFRI-TPKDLVLSGYQVPRGTGVLMGVLELSNDDKYFAQSSEFIPERWLKSDLAPDIQAC 458
            .:.|.|.|| :.|::.:..|:.|:.|..::....::.|::.|....:|.|:|||:.
 Frog   424 PVIPTNARIVSEKEVEIGEYRFPKNTLFVLSHYAIARDEENFEDPLKFKPQRWLRD--------- 479

  Fly   459 PAARTRNPFVYLPFGFGPRTCIGKRIAELEIETLLVRLLRSYKVSWLPE-TPIEYESTIILSP 520
             .....:||..:|||:|.|.|:||||||||:...|.|::|.:::.|.|: ..|:..:.|:|||
 Frog   480 -GGMKHHPFSSIPFGYGVRACLGKRIAELEMHLALSRVIRMFELRWDPKGEDIKSIARIVLSP 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12b2	NP_611370.2	CYP24A1-like	87..525	CDD:410677	127/458 (28%)
cyp27a1	XP_002933986.3	CYP27A1	118..547	CDD:410739	127/458 (28%)