Protein Alignment Sec6 and Exoc3l2

DIOPT Version :10

• Sequence 1: NP_611351.1
• Gene: Sec6 / 37142
• FlyBaseID: FBgn0266671
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: NP_001419505.1
• Gene: Exoc3l2 / 686809
• RGDID: 1592539
• Length: 788
• Species: Rattus norvegicus
• Alignment Length: 669
• Identity: 141/669 - (21%)
• Similarity: 270/669 - (40%)
• Gaps: 83/669 - (12%)

  Fly    79 RRMDEVERLLRGVPEVYDALEVVREENTKHSQYATAMENLKHIFNVDASVQKTMALIEDDKLLNA 143
            ||....|||   ||    |.|...|...|..:.....|.|        ||.:.:.||:..:|..|
  Rat   140 RRASLAERL---VP----AGEAAPEPPPKVPEPPKIKEPL--------SVLEILGLIQRRELARA 189

  Fly   144 HQCLADLENSRDDLLYELHKQPKQHASDKITLKRHFEKVDTVSQELEKKLRLILSRTLNTLRKKP 208
            .:.:.:||             .:..|..:....|....|..:.:.|:::|..::..:|    ..|
  Rat   190 DEHILELE-------------AEAPAEAEAGAGRRARDVALLYEALQRELWALVRESL----AAP 237

  Fly   209 ---TIIVTALRIIEREEKNDQFALQQQKVTGFLPPGRPKAWRRMIMDVLQQSVITRIEGSKLEER 270
               |..|..|.::         .||:::......||..:..|....:     .:.|....:|||.
  Rat   238 GPGTGAVAQLGLV---------LLQEEEADARRGPGAARKLRAHWAE-----AVARAARERLEEA 288

  Fly   271 A--DNKMWLVRDLEILRQIILEDLRVVKSLCVPCFPPHYDIFGEYVKFYHEGLSSYLDNIVRSGL 333
            |  ..:..|...||.||..:|||:..|:....|.:|........|::.|||.|:.:|....|..|
  Rat   289 AAPGARGTLSGQLEALRARLLEDVAAVRGRLAPAYPAGLRAGAVYLRGYHEALAEWLGAAARRRL 353

  Fly   334 EGNEYVSMMAWVTHTYPGVELMSHPDLNVDVHRQIGTLLRPEHLKALEDEYLQNMQRNFQEWMTK 398
            ...:..:::.|....||. |::...|:....:.::|.||....|:.||||.:.:::...:..:.:
  Rat   354 PLADRYALLHWHNQVYPR-EILGLVDVVALENGELGPLLSAGTLRGLEDECVTDVKAQTRAALLR 417

  Fly   399 AAETEKQEWFTETVPDQDEEYYHTSAPVIIFQMIDQHLQVTNTIHQELTFKALVMSIQQVEIFGQ 463
            ..:.::::|       ...:|..::....:.:::::|.:....|.||...:.....:..:..|.|
  Rat   418 VLQEDEEQW-------GSMDYRPSNLAQDVCELLEEHTERAPHISQEFVERMAYCCLGGLAEFLQ 475

  Fly   464 TYLKNVIELKEH-HFRNRDQIKYFTHYIITIVNNSQQMVELAQQMKQLYWPKSRTEHYEDFERLL 527
            ::.:.|....|: ..|......|.:. .|::||....:..||:::.::..|:|....    |...
  Rat   476 SFQQRVERFHENPGVRELPSDTYISR-TISMVNCGPPLRSLAERLARVGPPESEPAR----EASA 535

  Fly   528 ATFQRIRAHAASYLLEEAFLDMECHFNDLFTAKWLASNIAVDTICVTLDDYFQDYNHLRPNNFEM 592
            ....|:.......|.|..|.:::.|||.|...|||:|:.|:|.|..||.........::...:::
  Rat   536 IALDRVTRLCHRVLAELLFQELQPHFNKLMRRKWLSSSEALDGIVGTLGAQALALRRMQDEPYQV 600

  Fly   593 VINEAQKLLAKRYIRALLSKRLSKPRAEC-DAITR-----KIKTEAKRFKLFFEKIAPKISLSDS 651
            ::.|..:.....|:|.||..||     .| .|.||     :::.:|.:.:..|.::..:....|
  Rat   601 LVAELHRRALVEYVRPLLRGRL-----RCRSARTRSRMAGRLREDAAQLQRLFRRLESQAYWLD- 659

  Fly   652 PLDLISTLSALLS-SDIELLVLDLHTLLGSYPSLNEDHLVRLFYI---RNDVKAAEVREKVQDAM 712
              .::..|:.:|. .|...:.:::..|:..||.:...|:..|..|   ||.....|:....:|..
  Rat   660 --QVVPHLAEILQLEDTPSIQVEVGVLVRDYPDIRRKHVAALLDIRGLRNTAARQEILAVARDLE 722

  Fly   713 KSKKAMVSIAKQDCIFKEI 731
            .|:...:|.::....|.:|
  Rat   723 LSEGGALSPSRDRAFFADI 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec6	NP_611351.1	Sec6	179..731	CDD:450399	117/567 (21%)
Exoc3l2	NP_001419505.1	Sec6	214..721	CDD:450399	113/545 (21%)