Protein Alignment Sec6 and exoc3l1

DIOPT Version :10

• Sequence 1: NP_611351.1
• Gene: Sec6 / 37142
• FlyBaseID: FBgn0266671
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: NP_001092892.1
• Gene: exoc3l1 / 567832
• ZFINID: ZDB-GENE-061207-36
• Length: 780
• Species: Danio rerio
• Alignment Length: 737
• Identity: 212/737 - (28%)
• Similarity: 374/737 - (50%)
• Gaps: 45/737 - (6%)

  Fly     2 DLQQLEEQARQAALKDIQNMLQRPGQLEKVEQYRHRIARKKASVEALLKTGMQGQLDGVRVGLKQ 66
            :|::.|..||.||||....:..||..|||:.||:.|.:::.||:::.||:.:|..|:||..||.|
Zfish    24 ELERAECLARGAALKWASGVFCRPEHLEKLGQYKKRESQRTASIQSRLKSVVQSYLEGVDWGLGQ 88

  Fly    67 LETCMQDVREVRRRMDEVERLLRGVPEVYDALEVVREENTKHSQYATAMENLKHIFNVDASVQKT 131
            |.....::|.|...:.:.....|...|....||.:||.:..|.|...|:.||..::.|.:.|.:|
Zfish    89 LREARAELRGVSHDLYKANLESRKNSEEVTTLETLREISVSHCQLLAAVSNLPRLYKVRSMVLET 153

  Fly   132 MALIEDDKLLNAHQCLADLENSRDDLLYELH-----KQPKQHASDKITLKRHFEKVDTVSQELEK 191
            ..|:|..:||.||..|.:||..:|::|.:|.     ...:.::.|:..::.:|..|..:...|.|
Zfish   154 ERLVESRRLLEAHARLMELERWQDEVLLQLQGPRGSSGTELNSEDEELVRNYFSGVGRLVDALAK 218

  Fly   192 KLRLILSRTLNTLRKKPTIIVTALRIIEREEKNDQFALQQQK-VTGF---LPPGRPKAWRRMIMD 252
            :|..::...|:...:.||..|:|:||:||||..|||.|:::: .:|.   :|.|||:.||.....
Zfish   219 ELWAVVGSGLSLAHQNPTPFVSAVRIVEREEALDQFFLEERRSASGHNIPMPAGRPRNWRDRFFK 283

  Fly   253 VLQQSVITRIEG-SKLEERADNKMWLVRDLEILRQIILEDLRVVKSLCVPCFPPHYDIFGEYVKF 316
            |::::|..|... |.|..|...   |...|..|:..|:.||..|:.....|.|.||.:...|:.|
Zfish   284 VMEEAVSARFRSVSYLHTRGPG---LASHLSALQHCIMGDLSTVRHCLEQCVPAHYHLTRAYLHF 345

  Fly   317 YHEGLSSYLDNIVRSGLEGNEYVSMMAWVTHTYPGVELMSHPDLNVDVH-RQIGTLLRPEHLKAL 380
            .|:.|.::|..:....|||.|..:::.||.|.|...|:|..|.|..::. ..:|.|:..|.|:.|
Zfish   346 CHQFLQTHLGLVSGWELEGGEIFAVLNWVLHIYNSSEMMGEPALLAELEIENLGPLISQEGLEQL 410

  Fly   381 EDEYLQNMQRNFQEWMTKAAETEKQEWFTETVPDQDEE-YYHTSAPVIIFQMIDQHLQVTNTIHQ 444
            :::|:|.::::..|||.||.|.|..:|..:..||.|.| |||||.|.||.||::::.:|...|.:
Zfish   411 QNKYVQKVRKSVSEWMQKALEVELTDWQRDQEPDIDHEGYYHTSLPTIITQMLEENARVALMISE 475

  Fly   445 ELTFKALVMSIQQVEIFGQTYLKNVIELKEHHFRNRDQIKYFTHYIITIVNNSQQMVELAQQMKQ 509
            .|..:.:.|.:.::|.....:...|||..:.|.::....|::.||::..:||...:
Zfish   476 ALRDQTIQMGLYEMEKLLSRFRDAVIEFGKEHRKDPTVNKFYLHYLLACINNCIIL--------- 531

  Fly   510 LYWPKSRTEHYED---------FERL----LATFQRIRAHAASYLLEEAFLDMECHFNDLFTAKW 561
                |:.||..:.         :.|:    ||...|....|...:::....:::.|..:|.::.|
Zfish   532 ----KTSTESLQQQICSFVSNRYSRIPLGPLAALDRAVRKACRLVMDHLLFELQPHLQELLSSTW 592

  Fly   562 LASNIAVDTICVTLDDYFQDYNHLRPNNFEMVINEAQKLLAKRYIRALLSKRL-SKPRAECDAIT 625
            |........:|..|:.:.:.||.:|....:.:..|.|.|....|:||::.||| .:...|...:.
Zfish   593 LDQGDVTLNMCGVLERHCELYNRVRQPCRQRLKEECQWLTVVEYVRAVMQKRLVCRSSDEQKQLA 657

  Fly   626 RKIKTEAKRFKLFFEKIAPKISLSD-SPLDLISTLSALLS-SDIELLVLDLHTLLGSYPSLNEDH 688
            :::..:|::.:...:.:....::.: :|..||:.|:.::: :|..:|:|::..||..||.::|:|
Zfish   658 QRMTQDAQQLRDHLQSMEIDGTIGEVNPTALIAALADIINLNDPGMLLLEISGLLSKYPDISEEH 722

  Fly   689 LVRLFYIRNDVKAAEVREKVQD 710
            :..|..||.|| ..|||:.|.|
Zfish   723 VSVLLDIRGDV-PKEVRKSVLD 743

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec6	NP_611351.1	Sec6	179..731	CDD:450399	155/555 (28%)
exoc3l1	NP_001092892.1	Sec6	206..763	CDD:428738	155/555 (28%)