Protein Alignment Sec6 and Tnfaip2

DIOPT Version :10

• Sequence 1: NP_611351.1
• Gene: Sec6 / 37142
• FlyBaseID: FBgn0266671
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: NP_001420870.1
• Gene: Tnfaip2 / 299339
• RGDID: 1594556
• Length: 691
• Species: Rattus norvegicus
• Alignment Length: 685
• Identity: 149/685 - (21%)
• Similarity: 278/685 - (40%)
• Gaps: 106/685 - (15%)

  Fly    96 DALEVVREENTKHSQYATAMENLKHIFN------------VDASVQKTMALIEDDKLLNAHQCLA 148
            :|.|...|...|..:.:..:.|:..:|.            .|..||......||..|....:...
  Rat    55 EAPEGEEESAKKKEKKSKGLANMFSVFTKGKKKKKDQPRLSDPEVQSKSRPEEDGPLPTVEELKE 119

  Fly   149 DLENSRDDLLYELHKQPKQHASDKITLKRHFEKV----DTVSQEL---EKKLR----LILSRTLN 202
            .||..|.::.:::           :.|:|..|..    .|..:||   :.|:.    |:..:.|.
  Rat   120 ALELGRLEVAWQV-----------LALERQLEAAAAAGGTSDEELVWRQSKVEALYVLLRDQVLR 173

  Fly   203 TLRK----KPTIIVTALRIIEREEKNDQFALQQQKVTGFLPPGRPKAWRRMIMDVLQQSVITRIE 263
            .||:    .|..:..||.::.:||..|:.|.:....|. |...||:.|.::...|:.:....|::
  Rat   174 VLRRPLEAAPERLSQALAVVSQEELEDRRASRGPLATA-LAITRPRRWLQLWRGVVAEVAAERLD 237

  Fly   264 GSKL-----EERADNKMWLVRDLEILRQIILEDLRVVKSLCVPCFPPHYDIFGEYVKFYHEGLSS 323
            ....     ...|:|     |.|.:.| .:.||:.||.....|.||..:::...|.:.|||..::
  Rat   238 AQPAFVPEGRSEAEN-----RFLHMGR-TMREDMEVVVERLKPLFPEEFNVVHTYAESYHEHFAT 296

  Fly   324 YLDNIVRSGLEGNEYVSMMAWVTHTYPGVELMSHPDLNVDVHR-QIGTLLRPEHLKALEDEYLQN 387
            :|..:.:..|...:...::.||.:.||. ::::.|.|..::.. ::|:||.|:.::.||..:|.|
  Rat   297 HLCTLAQFELCERDTYLLLLWVQNFYPN-DILNSPKLAQELQGIRLGSLLPPKQIRLLEAVFLSN 360

  Fly   388 MQRNFQEWMTKAAETEKQEWFTETVPDQDEEYYHTSAPVIIFQMIDQ------------HLQVTN 440
            ...|.::.||:|.|.|.|.|..:..|...:...|:...:.|.|:|.|            .:|:..
  Rat   361 EVTNVKQLMTRALELESQRWAQDVAPQSLDGRRHSELAIDILQIISQGQTKAENITSDVGMQIKQ 425

  Fly   441 TIHQELTFKALVMSIQQVEIFGQTYLKNVIELKEHHFRNRDQIKYFTHYIITIVNNSQQMVELAQ 505
            .:..||.  ||:.|.|:|  |.:...|:               |...:|.:.|:.|....:....
  Rat   426 LLLVELA--ALLRSYQRV--FDEFLEKS---------------KLLRNYRVNIIANINNCLSFRT 471

  Fly   506 QMKQLYW--PKSRTEHYEDFERLLATFQRIRAHAASYLLEEAFLDMECHFNDLFTAKWLASNIAV 568
            .::| .|  |:      :...||:...:.::||....||:..|.|::..|......:|......:
  Rat   472 SVEQ-RWQIPQ------DSLNRLVEPLKDLKAHGFDTLLQSLFSDLKPLFKKFTQTRWAKPVETL 529

  Fly   569 DTICVTLDDYFQDYNHLRPNNFEMVINEAQKL-LAKRYIRALLSKRLSKPRAE-CDAITRKIKTE 631
            :.|..|:.....:::.|: :.|...:.||..| |.|.||..|..:||....|| ...:.:.|...
  Rat   530 EEIITTVSVSLPEFSELQ-DCFREELMEAVHLHLVKEYIIRLSKRRLVLKTAEQQQQLAKHILAN 593

  Fly   632 AKRFKLFFEKIAPKISLSDSPLDLISTLSALLSSDIELLVLDLHTLLGSYPSLNEDHLVRLFYIR 696
            |...:.|..:.....:...:.|..||.:..|  .|...:.:::.|....||..::.||..:..|:
  Rat   594 ADTIQHFCTENGSTATWLHAALPTISEIIRL--QDPSAIKIEVATYATWYPDFSKGHLNAILAIK 656

  Fly   697 NDVKAAEVRE---------KVQDAMKSKKAMVSIA 722
            .::.::|||.         .||:..:...:::.:|
  Rat   657 GNLPSSEVRSIRNILDINTGVQELSRPLFSLIKVA 691

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec6	NP_611351.1	Sec6	179..731	CDD:450399	132/590 (22%)
Tnfaip2	NP_001420870.1	Sec6	157..688	CDD:428738	127/567 (22%)