Protein Alignment Sec6 and Exoc3l4

DIOPT Version :10

• Sequence 1: NP_611351.1
• Gene: Sec6 / 37142
• FlyBaseID: FBgn0266671
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: NP_001100229.1
• Gene: Exoc3l4 / 299338
• RGDID: 1307749
• Length: 721
• Species: Rattus norvegicus
• Alignment Length: 695
• Identity: 138/695 - (19%)
• Similarity: 265/695 - (38%)
• Gaps: 109/695 - (15%)

  Fly    75 REVRRRMDEVERLLRG------VPE----VYDALEVVREENTKHSQYATAM--ENLKHIFNVDAS 127
            |.:||.:|  |.|..|      |||    |.|.:.         .|.||.:  |:|:.    .|.
  Rat    85 RSLRRALD--EGLTAGHPQGTAVPEKPSRVTDGVS---------QQAATGVEAEDLER----QAE 134

  Fly   128 VQKTMALIEDDKLLNAHQCLADLENS--RDDLLYELHKQPKQHASDKITLKRHFEKVDTVSQELE 190
            .:....||.:.:|:.|.:.|..||..  .|.......:.|..:|...:.|..|::       .:.
  Rat   135 SKSVADLITERQLVKAFEQLRYLETQLVADKTSRTFTQDPTAYARRAMDLCLHYD-------GMA 192

  Fly   191 KKLRLILSRTLNTLRKKPTIIVTALRIIEREEKNDQFALQQQKVTGFLPPGRPKAWRRMIMDVLQ 255
            .::..|:...||:.......:....:::..||:..|.|   |....||  ..|:.||:...|.::
  Rat   193 AEIGAIVREALNSEGVDRDALAELAQVVHLEEEAHQTA---QAEGDFL--STPRHWRQHWEDAVR 252

  Fly   256 QSVITRIE--GSK-LEERADNKMWLVRDLEILRQIILEDLRVVKSLCVPCF-PPHYDIFGEYVKF 316
            .|...|::  |:| :...|:....|.:.|..|..::..||:.|:|...|.: ...:.::..|::.
  Rat   253 LSAQERVQQAGAKVIPGAAEGASDLAQLLAELGGVVRRDLQKVRSEMQPAYEATDFPVWETYLRA 317

  Fly   317 YHEGLSSYLDNIVRSGLEGNEYVSMMAWVTHTYPGVELMSHPDLNVDVHRQIGTLLRPEHLKALE 381
            :|..::..|..:.|......:...::.|..:.|...:.:..|||.:.. ..:..||.|.....||
  Rat   318 FHSAVAQRLQELARDARGCEQLYVLLDWAANVYGSPDFLGAPDLALPT-EPLPPLLEPALWARLE 381

  Fly   382 DEYLQNMQRNFQEWMTKAAETEKQEWFTETVPDQD--EEYYHTSAPVIIFQMIDQHLQVTNTIHQ 444
            .:|...::...........:.|:..|  |...|.:  :..||....:.:..::.:|::....|..
  Rat   382 SDYTSFLETKITSCFDSILQLEQSRW--EAGEDLEVLQGLYHAPLSIDVHMLVAEHVKAAGAISA 444

  Fly   445 ELTFKALVMSIQQVEIFGQTYLKNVIELKEHHFRNRDQIK--YFTHYIITIVN-NSQQMVELAQQ 506
            ||....|.:..:.:.:|...:.|..:..|        .:.  |...||...|. .:..:......
  Rat   445 ELEATTLQICARALCLFVPRFEKAFLASK--------AVSEWYLGAYINACVELRTSLLARFPGT 501

  Fly   507 MKQLYWPKSRTEHYEDFERLLATFQRIRAHAASYLLEEAFLDMECHFNDLFTAKWLASNIAVDTI 571
            :|:|..|            |:|.....:.|    ||:.|..|::..|..|:|..||..    ||:
  Rat   502 IKELERP------------LVAATNNFQKH----LLQIAQQDIQPLFKVLYTRNWLTQ----DTL 546

  Fly   572 CVTLD---DYFQDYNHLRPNNFEMVINEAQKLLAKRYIRALLSKRLSKPRAECDAITR-----KI 628
            ...:|   |:.....|:.|...:..:.|..:.:.:.|:..:|     :|......:.|     |:
  Rat   547 HPLMDKVVDFAHHLEHVTPPLAQDTLQEVHRFVVREYLGQVL-----RPHERFSGLDRVKGSHKM 606

  Fly   629 KTEAKRFKLFFEKIAPKISLSDSPLDLIS-TLSALLSSDIELLVLDLHTLLGSYPSLNEDHLVRL 692
            ..:|:.....|..:..:....|..:..:: .|......||.   ..|.||:.|||.:..||::.:
  Rat   607 SLDAQAISNTFRGLGSEAKWLDQAIPSVAEILGETYKDDIR---RHLETLIRSYPDIRRDHILAI 668

  Fly   693 FYIRNDVKAAEVREKVQDAMKSKKAMVSIAKQD------CIFKEI 731
            ..:|.     ..|.:.|:.::..:.::..|.::      .:|:||
  Rat   669 LALRR-----LGRRRNQNLLQHTQDLLRAAHENRPSSHHVLFEEI 708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec6	NP_611351.1	Sec6	179..731	CDD:450399	106/575 (18%)
Exoc3l4	NP_001100229.1	Sec6	182..708	CDD:450399	108/581 (19%)