Protein Alignment Sec6 and Exoc3l1

DIOPT Version :10

• Sequence 1: NP_611351.1
• Gene: Sec6 / 37142
• FlyBaseID: FBgn0266671
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: NP_001099648.1
• Gene: Exoc3l1 / 291961
• RGDID: 1311132
• Length: 743
• Species: Rattus norvegicus
• Alignment Length: 729
• Identity: 177/729 - (24%)
• Similarity: 336/729 - (46%)
• Gaps: 62/729 - (8%)

  Fly     4 QQLEEQARQAALKDIQNMLQRPGQLEKVEQYRHRIARKKASVEALLKTGMQGQLDGVRVGLKQLE 68
            ::.|:.||.||||....:..||.||.::.|||.|..::..|:||.:|:.:|..|:||:.|:.||.
  Rat    28 ERAEQLARGAALKWASGIFYRPEQLTRLGQYRSREVQRNYSLEARIKSAVQSYLEGVQTGVWQLT 92

  Fly    69 TCMQDVREVRRRMDEVERLLRGVPEVYDALEVVREENTKHSQYATAMENLKHIFNVDASVQKTMA 133
            ..::.|:..|..:.:...||:|:.:....||.:||...:|.|.....:.|..:..|.|:|..|..
  Rat    93 QALEAVQGTREALRQAHHLLQGLSQTSQTLEPMRECVVQHKQLQILTQLLPRLQAVPAAVAHTQT 157

  Fly   134 LIEDDKLLNAHQCLADLENSRDDLLYELHKQPKQHASDKITLKRHFEKVDTVSQELEKKLRLILS 198
            ||:..:.|.|:..|.:||..:::....|       ...::.:   |:::..:::.|.:.:.....
  Rat   158 LIDAQRFLEAYVNLRELEQLQEETWTPL-------GGLELPI---FQELGLLAEALGQAVEAAAG 212

  Fly   199 RTLNTLRKKPTIIVTALRIIEREEKNDQFALQQQKVTGFLPPGRPKAWRRMIMDVLQQSV-ITRI 262
            ......|:.||::|.|:|:.|.|        .::.:.|    ..|:.||:..:..||:.: ....
  Rat   213 AAGRLAREDPTLLVAAIRVAEVE--------TERTILG----QAPRDWRQRCLRALQEGLEQLHF 265

  Fly   263 EGSKLEERADNKMWLVRDLEILRQIILEDLRVVKSLCVPCFPPHYDIFGEYVKFYHEGLSSYLDN 327
            ....|.|......|    ||.|:..:..:|...::|..||.||.|.:...:....|.||...|..
  Rat   266 ASPVLPEPGALSGW----LEALQVALPAELATAEALVAPCCPPSYHVVRLWAHTLHSGLRRSLQQ 326

  Fly   328 IVRSG--LEGNEYVSMMAWVTHTYPGVELMSHPDL--NVDVHRQIGTLLRPEHLKALEDEYLQNM 388
            :: ||  |...:..:::.|..|.|.|.|:|.:.:|  ..|| .|:..||..|:::.||..::..:
  Rat   327 LL-SGPELGAADTFALLHWALHVYMGKEMMGNLELGPEADV-SQLEPLLTSENIEQLEAAFVAQV 389

  Fly   389 QRNFQEWMTKAAETEKQEWFTETVPDQDEE-YYHTSAPVIIFQMIDQHLQVTNTIHQELTFKALV 452
            |.:..:|:.||.:.|..||..|..|..|.. :||:..|.|:.|::.:::|||:.|...|..:...
  Rat   390 QVSVAQWLKKALDGEVAEWSREQEPTTDPSGFYHSPMPAIVLQILAENIQVTSLISDSLHRRVHD 454

  Fly   453 MSIQQVEIFGQTYLKNVIELKEHHFRNRDQIKYFTHYIITIVNNSQQMVELAQQMKQLYWPKSRT 517
            |::.::..|.:::..::|.....|.|......::..|::...|:...:    :....:..|...|
  Rat   455 MAVSELGAFLRSFSDSLIRFSRDHLRGEAVAPHYVPYLLAAFNHQSAL----RSSVSVLLPDGET 515

  Fly   518 E--------HYEDFERLLATFQRIRAHAASYLLEEAFLDMECHFNDLFTAKWLASNIAVDTICVT 574
            .        ..:|.||.:...          :||....:::..|..|.:.:||.|:..:|::...
  Rat   516 SGVLAPVEAALDDVERRICRL----------VLEVLQAELQPLFAALPSRRWLLSSELLDSVYEQ 570

  Fly   575 LDDYFQDYNHLRPNNFEMVINEAQKLLAKRYIRALLSKRL-SKPRAECDAITRKIKTEAKRFKLF 638
            ...:.:|:..:|....::::.|.::.:...|:|||:..|| .:...|......:::.:|.:.|..
  Rat   571 TLHFCKDFWRVRKPAVQLLLTETERTVVLHYLRALMQGRLVCRGADERSQAAERLQHDAAQLKEL 635

  Fly   639 FEKIAPKISLSDSPLDLISTLSALLSSDIELLVLDLHTLLGSYPSLNEDHLVRLFYIRNDVKAAE 703
            |..:..:.|...:|: |::....|...|..||.|::..|...:|.::|||:..|..:|.||.
  Rat   636 FLGLGLEESAHCAPV-LLALRELLNLHDPTLLGLEVAGLRQQFPDVSEDHVSALLDLRGDVS--- 696

  Fly   704 VREKVQDAMKSKKA 717
             ||..|.|:.|.:|
  Rat   697 -REHRQAALSSLQA 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec6	NP_611351.1	Sec6	179..731	CDD:450399	127/554 (23%)
Exoc3l1	NP_001099648.1	Sec6	193..726	CDD:428738	127/554 (23%)