Protein Alignment Atg7 and ATG7

DIOPT Version :10

• Sequence 1: NP_611350.1
• Gene: Atg7 / 37141
• FlyBaseID: FBgn0034366
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: XP_054200913.1
• Gene: ATG7 / 10533
• HGNCID: 16935
• Length: 768
• Species: Homo sapiens
• Alignment Length: 704
• Identity: 291/704 - (41%)
• Similarity: 415/704 - (58%)
• Gaps: 86/704 - (12%)

  Fly     9 LQFAPWESFVSPTFWHKLAELKLDHDRLSDSKRSITGHYTNRNASG--CLLEVDYTAYNRMAKPP 71
            |||||:.|.:...|||:|.:.||:..||.::.:.|.|:|.|.:::|  ..|.::::|::..|..|
Human    13 LQFAPFSSALDVGFWHELTQKKLNEYRLDEAPKDIKGYYYNGDSAGLPARLTLEFSAFDMSAPTP 77

  Fly    72 KFSHSAIGTIYNKNTIEEFKALDKLQLLADEGKELLADMCSGGALRDPSLLTRFFVLSFADLKCH 136
            .....||||:||.||:|.||..||..||.....|:...:.||.||.:|.||.:|.:|:|||||.:
Human    78 ARCCPAIGTLYNTNTLESFKTADKKLLLEQAANEIWESIKSGTALENPVLLNKFLLLTFADLKKY 142

  Fly   137 SYYYWFAFPCPLTP-TLKL-QGAVQKLRDLPNSSSYIMALK-------------ALPTESQNFFI 186
            .:||||.:|....| :|.| ||.|.  .|...|...|.||:             |||    .|.|
Human   143 HFYYWFCYPALCLPESLPLIQGPVG--LDQRFSLKQIEALECAYDNLCQTEGVTALP----YFLI 201

  Fly   187 LYANVEKNIFEARSLSSLDDKNVEFCYF---------GFADPSEY-EHPAWIMRNY--------- 232
            .|   ::|:.....|....|      :|         |..||... ::|.|.:||:
Human   202 KY---DENMVLVSLLKHYSD------FFQGQRTKITIGVYDPCNLAQYPGWPLRNFLVLAAHRWS 257

  Fly   233 AAFLLQQCPSFVGKPLKFLGLRHNQQMNIDDSLVWKVIQTEACDLSQSENI-KFVGWELNKNGKM 296
            ::|...:...|..:.::  |.|     ::..|::::|   :..:::.|.:. |.||||.|:.|.|
Human   258 SSFQSVEVVCFRDRTMQ--GAR-----DVAHSIIFEV---KLPEMAFSPDCPKAVGWEKNQKGGM 312

  Fly   297 GPRMVCMRDSMDPAKLAENSVNLNLKLMKWRLVPDLNLEIISQTKCLLFGAGTLGCAVARNLLSW 361
            |||||.:.:.|||.:|||:||:||||||.|||||.|:|:.:...||||.|||||||.|||.|:.|
Human   313 GPRMVNLSECMDPKRLAESSVDLNLKLMCWRLVPTLDLDKVVSVKCLLLGAGTLGCNVARTLMGW 377

  Fly   362 GFKHITLLDSGKVGFSNPVRQNLYTHADAVAGNRMKATTAAQRLKEINPSAETAGYVLEIPMPGH 426
            |.:|||.:|:.|:.:||||||.||...|.:.|.:.||..||.||::|.|.....|:.:.||||||
Human   378 GVRHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALAAADRLQKIFPGVNARGFNMSIPMPGH 442

  Fly   427 TIGES--LLAQTKEHLKVIEKLVQDHDVIFLLTDSRESRWLPTLLGAAKEKIVINAALGFDSYLV 489
            .:..|  .|.|.:..::.:|:|::.|||:|||.|:|||||||.::.|:|.|:|||||||||:::|
Human   443 PVNFSSVTLEQARRDVEQLEQLIESHDVVFLLMDTRESRWLPAVIAASKRKLVINAALGFDTFVV 507

  Fly   490 MRHGTTRKE---AGD-------DGQEIEGLKC---INGDQLGCYFCNDVTAPGNSLKDRTLDQQC 541
            ||||..:.:   |||       ...::.|...   |.|.:|||||||||.|||:|.:||||||||
Human   508 MRHGLKKPKQQGAGDLCPNHPVASADLLGSSLFANIPGYKLGCYFCNDVVAPGDSTRDRTLDQQC 572

  Fly   542 TVTRPGVSNIAASYAVELLVALLQHPRKELAPAYYAQSGRGRSEETEEKVPEGLLGILPHSIRGM 606
            ||:|||::.||.:.||||:|::||||....|   .|.|...|..|     |...||::||.|||.
Human   573 TVSRPGLAVIAGALAVELMVSVLQHPEGGYA---IASSSDDRMNE-----PPTSLGLVPHQIRGF 629

  Fly   607 LCNYENILPATQKFAQCIACSAAVLNEYKKEGHAFLFKTFETA-KFLEDLTGIS 659
            |..::|:||.:..|.:|.|||:.||::|::||..||.|.|.:: .|||||||::
Human   630 LSRFDNVLPVSLAFDKCTACSSKVLDQYEREGFNFLAKVFNSSHSFLEDLTGLT 683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg7	NP_611350.1	E1_like_apg7	11..682	CDD:273590	289/702 (41%)
ATG7	XP_054200913.1	E1_like_apg7	15..695	CDD:273590	289/702 (41%)