Protein Alignment Prp19 and prpf19

DIOPT Version :10

• Sequence 1: NP_523783.1
• Gene: Prp19 / 37123
• FlyBaseID: FBgn0261119
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: XP_031760828.1
• Gene: prpf19 / 448017
• XenbaseID: XB-GENE-975233
• Length: 504
• Species: Xenopus tropicalis
• Alignment Length: 506
• Identity: 332/506 - (65%)
• Similarity: 412/506 - (81%)
• Gaps: 4/506 - (0%)

  Fly     1 MALVCALTNEVPETPVVSPHSGAVFEKRVIEKYLLENGCDPISGKELKPEELIEIKTPAVVKPKP 65
            |:|.|.::|||.:.|.:||.||.:|::|:|||||.|||.||::.:.|..::||:||....::|||
 Frog     1 MSLTCYISNEVTDRPCISPVSGHIFDRRLIEKYLAENGTDPVTNQPLSEDQLIDIKVAHPIRPKP 65

  Fly    66 PSATSIPATLKTMQDEWDALMIHSFTQRQQLQTTRQELSHALYQHDAACRVIARLNKEVAAAREA 130
            ||||||||.||::||||||:|:||||.||||||||||||||||||||||||||||.|||.|||||
 Frog    66 PSATSIPAILKSLQDEWDAVMLHSFTLRQQLQTTRQELSHALYQHDAACRVIARLTKEVTAAREA 130

  Fly   131 LATLKPQAGIANAPTAIPQPALASEAGGAAAHPM-EQAGMSAEVIQKLQDKATVLTQERKKRGRT 194
            |||||||||| :.|.|.|.|. |..||.|.|..: |..|||||:||||||||||||.||||||:|
 Frog   131 LATLKPQAGI-SVPQASPMPQ-AGAAGSAEAMELGELIGMSAEIIQKLQDKATVLTTERKKRGKT 193

  Fly   195 VPEDLVTTDQVKNFLTVASHPGLHSASVPGILALDINSADHSKILTGGNDKNATVFNKDTEQMVA 259
            ||||||..:::..:..|:||.||||||||||||||:...|.:|.||||.||:..||:..::|::|
 Frog   194 VPEDLVKPEELSKYHQVSSHVGLHSASVPGILALDLCPTDTNKTLTGGADKSVVVFDALSQQILA 258

  Fly   260 ILKGHTKKITKVIYHPNEDTVITGSPDMNIRIWHVPTSQTQLLLRCHEGPVTGLSLHPTGDYLLS 324
            .|||||||:|.|::||:::.|.:.|||..||:|.||.:....:||.|||.|||||||.|||||||
 Frog   259 TLKGHTKKVTSVVFHPSQELVFSASPDSTIRVWSVPDASCAQVLRAHEGAVTGLSLHATGDYLLS 323

  Fly   325 TSSDKHWAFSDIRTGRLLTKVID-TAEVGLTTAQFHPDGLIFGTGTVDSQVKIWDLKEQSNVANF 388
            .|.|::||||||..||:||||.| ::...||.||||||||||||||||||:|||||||:||||||
 Frog   324 CSDDQYWAFSDIHVGRVLTKVTDESSGCALTCAQFHPDGLIFGTGTVDSQIKIWDLKERSNVANF 388

  Fly   389 PGHTGPISAISFSENGYYLATAADDACVKLWDLRKLKNFKTIQLDDGYEVKDLCFDQSGTYLAIA 453
            |||:||:|.|:||||||||||||||:.||||||||||||||:||::||:|:.|.|||||||||:.
 Frog   389 PGHSGPVSCIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLEEGYQVRSLVFDQSGTYLAVG 453

  Fly   454 GSDVRVYLCKQWQELKVFNDHTALATGVRFGKHAQYLASTSMDRTLKLYAI 504
            |:|::||:||||.|:..|.||:||.||:.||::|::||||.|||:|:.|::
 Frog   454 GTDIQVYICKQWAEVLHFTDHSALTTGLAFGQNAKFLASTGMDRSLRFYSL 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp19	NP_523783.1	RING-Ubox_PRP19	3..56	CDD:438318	25/52 (48%)
		Prp19	69..133	CDD:400774	55/63 (87%)
		WD40	210..503	CDD:238121	193/293 (66%)
		WD40 repeat	269..305	CDD:293791	14/35 (40%)
		WD40 repeat	310..345	CDD:293791	26/34 (76%)
		WD40 repeat	354..389	CDD:293791	31/34 (91%)
		WD40 repeat	395..431	CDD:293791	30/35 (86%)
		WD40 repeat	438..484	CDD:293791	27/45 (60%)
prpf19	XP_031760828.1	RING-Ubox_PRP19	3..56	CDD:438318	25/52 (48%)
		Prp19	69..133	CDD:400774	55/63 (87%)
		WD40 repeat	224..262	CDD:293791	18/37 (49%)
		WD40	<233..504	CDD:441893	177/270 (66%)
		WD40 repeat	268..304	CDD:293791	14/35 (40%)
		WD40 repeat	309..344	CDD:293791	26/34 (76%)
		WD40 repeat	354..389	CDD:293791	31/34 (91%)
		WD40 repeat	395..431	CDD:293791	30/35 (86%)