DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ttd14 and unc-132

DIOPT Version :9

Sequence 1:	NP_001097366.1	Gene:	Ttd14 / 37119	FlyBaseID:	FBgn0284257	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_504030.2	Gene:	unc-132 / 178787	WormBaseID:	WBGene00021078	Length:	501	Species:	Caenorhabditis elegans

Alignment Length:	491	Identity:	205/491 - (41%)
Similarity:	279/491 - (56%)	Gaps:	74/491 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QQSVMASTSNGQEQQR----------HQDEPEQQQQVEIRKSSSPKPGAMPSLKLNRMGSVSPKD 63
            :||.|:||.......|          :.:...||.|...:...||       :|.....||| .:
Worm    46 RQSSMSSTVAAASASRRVSPIYPKMNNNNNNHQQNQHHRKYRVSP-------VKTTCSRSVS-LE 102

  Fly    64 KRVYKIVLTGGPCGGKTTGQSRLCTFFENLGWKVFRVPETATVLLSGGVKFSDL-TEKEDPPTPT 127
            ::||||||||||||||||.|.||.|||||||||||.||||||:||.|.||||:| ||
Worm   103 RKVYKIVLTGGPCGGKTTAQVRLATFFENLGWKVFTVPETATILLGGRVKFSELDTE-------- 159

  Fly   128 TFVYKDLPFAAPEHSLIDLTASCPRCLAKAASRPNGSEAYKFQENLIRTMVQIENTYFELGNS-S 191
                                                 ::|.||.:|:.||.|||||:|...:: .
Worm   160 -------------------------------------QSYIFQRDLLATMHQIENTFFNQASAIK 187

  Fly   192 NRNCLIICDRGVMDASAYISKDKWEKMMAGNNWNPVEMRDNRYNQILHLVSAANGAEDFYSTEDH 256
            :||.|||||||.||.|||.|.:.|::|:...|:...::|.:||:||.|||:||:|||.:|:..::
Worm   188 DRNVLIICDRGCMDPSAYSSPEDWQRMLKDLNYEEFDLRCSRYDQIAHLVTAADGAEKYYTLANN 252

  Fly   257 ACRSEGVDLARELDYKSAAAWVGHPYFDVID--NSTNFETKMNRMIESVCQKLGIDIGDRLQATS 319
            |.|||||..|.|||.::.:.|:||||.|:||  |::.|:.|:|::|:.||.:.||..||||...|
Worm   253 ATRSEGVSHAMELDKRTRSVWIGHPYMDIIDNKNTSTFDDKVNKLIQVVCDRTGIRSGDRLAKDS 317

  Fly   320 RKLKYLVALLPPD-SEFPPFQDFDVVHHYLQSAGPKVQARLRKRGQKNHWSYIHTQRRPNVHGQA 383
            :|.|:||:.:  | ..|..|::||:.|.||.|....:|.|.|:|.|.|..:|..|.|......:.
Worm   318 KKRKWLVSAV--DWKNFGKFEEFDIEHFYLLSDESNIQHRFRRRTQNNRSTYTLTSREYFKESKD 380

  Fly   384 RIEVKTQLTHRDYMNLLAQRDDAHFTIYKKRRCFLINNQYFQLDIYKEPGHPRCKG--LVLLETY 446
            .||.:..:..|||......||.:..:||||||||:..|.||.:|||.:|..|:..|  |:.||||
Worm   381 SIETRMNVLSRDYNTYANMRDKSRASIYKKRRCFMYGNMYFNMDIYSDPLPPQANGNHLIFLETY 445

  Fly   447 SSLT-GDAL-KNCMPKFLNIVKEVTGDPDYSMFNLS 480
            :::. |..| :..||.||.|.||:|||..|||::||
Worm   446 TTVVKGTPLPEGSMPPFLTIEKEITGDSQYSMYSLS 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttd14	NP_001097366.1	AAA_28	68..293	CDD:290255	107/228 (47%)
Ttd14	NP_001097366.1	CYTH-like_Pase	323..481	CDD:299847	67/163 (41%)
unc-132	NP_504030.2	AAA_28	107..287	CDD:379235	106/224 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162489
Domainoid	1	1.000	221	1.000	Domainoid score	I1496
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H16204
Inparanoid	1	1.050	363	1.000	Inparanoid score	I1275
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48770
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0016832
OrthoInspector	1	1.000	-	-		oto17598
orthoMCL	1	0.900	-	-		OOG6_106621
Panther	1	1.100	-	-	LDO	PTHR34932
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16927
SonicParanoid	1	1.000	-	-		X13643
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.930