Protein Alignment adp and Dcaf6

DIOPT Version :10

• Sequence 1: NP_611296.2
• Gene: adp / 37073
• FlyBaseID: FBgn0000057
• Length: 628
• Species: Drosophila melanogaster
• Sequence 2: XP_036009808.1
• Gene: Dcaf6 / 74106
• MGIID: 1921356
• Length: 968
• Species: Mus musculus
• Alignment Length: 935
• Identity: 198/935 - (21%)
• Similarity: 308/935 - (32%)
• Gaps: 379/935 - (40%)

  Fly    28 LHW--QRQQYGHELDEMLRRRLLASPAYVDRLEQEAVLVGHEGCVNCLEWTTDGMWLASGSDDYR 90
            |.|  :::..|.|....||.|.|....::.||:.||.|..|:||||.:.|...|.::.|||||.:
Mouse    10 LLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTK 74

  Fly    91 VMIWDPFRKKLVHVIRTKHLGNVFSVKFLPKTNNSIVATCAADKFIYVYDINDPNETLFSC--IC 153
            ::|.:|:.:|::..||:.|..|:||.||||.|::..:.:|:.|..|:..:|....||...|  .|
Mouse    75 LVISNPYSRKVLTTIRSGHRANIFSAKFLPCTDDKQIVSCSGDGVIFYTNIEQDAETNRQCQFTC 139

  Fly   154 HFSRAKRLATAQDSPHVFWSAGEDGCILQLDIREPHRCRPEEGIGVRLLNLHDQLENTEAKCLAI 218
            |:.....:.|..:.|:.|.|.||||.:...|.|....|..|:.....|:|.     ...|..:||
Mouse   140 HYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINC-----RRAATSVAI 199

  Fly   219 NPRRTEYLAVGTNDPFARVYDRRKLPST-----NGNGLSACVAYYAPGQIVKNISRNIVHEPRGI 278
            .|....|||||.:|...|:||||.|.:.     .|.|.:..||.:.|..:.....|        :
Mouse   200 CPPVPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLSNKSCR--------V 256

  Fly   279 TYLTFNGNGTELLVNIGCEHVYRFDLNH------------------AEPPV-------------- 311
            |.|.::.:|.|:||:...:::|.||...                  .:|||
Mouse   257 TSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGP 321

  Fly   312 --------------------FYDLPAFTSTLVHEEEPVKMPHRSR---------------SLPT- 340
                                ...:....|....|...|...:|.|               :|||
Mouse   322 RARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRPRPRGGTNQPDVSTLPTV 386

  Fly   341 ----EIEVYK---------------KEGNDFLENGKLVDAIDA-YSAALAKYPQGEVL------- 378
                .:||.:               ....|.::......||:: .|::|...|..|..
Mouse   387 PSSPNLEVCETAMDVDMPAALLQPSTSSTDPVQAQAATAAIESPRSSSLLSCPDSEPRQSVEASG 451

  Fly   379 -YLNRATALMRRGWFGDIYAALRDCHEALRLDPSYVKAHFRLARA-------------------- 422
             :.:..:..:|    |...|.||...:.|||..:..:....||:|
Mouse   452 HHAHHQSEFLR----GPEIALLRKRLQQLRLKKAEQQRQQELAQAQHQPPTSTSDPPPHEGSSRD 512

  Fly   423 ----------------------------------------LLELH-------------------- 427
                                                    :|.||
Mouse   513 PRASDSPSSVVNKQLGSMSLDEQQDNSNERLSPKPGTGEPVLSLHYSTEGTTTSTIKLNFTDEWS 577

  Fly   428 -------------RPQDADQCL--QALIQ--------RFPDFANNHGVLM--------------- 454
                         :.:..::||  .:.:|        |.|:..:..|.|.
Mouse   578 STASSSRGNGSHCKSEGQEECLVPPSSVQPPEGDSETRAPEELSEKGTLPENLTQNQIDTAQLDN 642

  Fly   455 -------LNKDIKEN-------------------------------------------------- 462
                   .|...|.|
Mouse   643 FPAEPLDSNSGEKNNPSQDSPCGLPEEGTLSETDRETCEQASTESATRHASTKPELPSQTEAIEQ 707

  Fly   463 -------RRQSKSPEAPE----LQPV-------------EVDD---------GFRYLRLKNAEYD 494
                   |..|.:||.|.    :.|:             :.||         |.||.......::
Mouse   708 ASTESATRHTSANPELPSQTEAIAPLAHEDPSARDSALQDTDDSDDDPVLIPGARYRTGPGDRFN 772

  Fly   495 LRSTA--------------RDYMQR-----------------------YVGHCNVTTDIKEANYL 522
            :|.|.              :::.:|                       |.||.|..|.|||||:.
Mouse   773 IRGTTVGDRIMRRSAVARIQEFFRRRKERKEMEELDTLNIRRPLVKMVYKGHRNSRTMIKEANFW 837

  Fly   523 GSQGEFIAAGSDDGNMYIWEGDTGKIRAVYRADSAIVNCVQPHPSICMLATSGIDHNIKIWSPCA 587
            |:  .|:.:|||.|:::||:..|.:...:..||:.:|||:||||...:||:||||::||||||..
Mouse   838 GA--NFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWSPLE 900

  Fly   588 AS-------AEE---RPNLVADVTR 602
            .|       |:|   |..|:.:.||
Mouse   901 ESRIFNRKLADEVITRNELMLEETR 925

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
adp	NP_611296.2	WD40	54..>242	CDD:475233	68/189 (36%)
		WD40 repeat	72..108	CDD:293791	12/35 (34%)
		WD40 repeat	114..154	CDD:293791	14/41 (34%)
		WD40 repeat	158..203	CDD:293791	13/44 (30%)
		WD40 repeat	214..268	CDD:293791	20/58 (34%)
		Spy	338..>461	CDD:443119	34/276 (12%)
		TPR repeat	342..370	CDD:276809	6/43 (14%)
		TPR repeat	375..408	CDD:276809	7/40 (18%)
		TPR repeat	413..441	CDD:276809	8/122 (7%)
		WD40 repeat	513..553	CDD:293791	15/39 (38%)
		WD40	<526..584	CDD:475233	26/57 (46%)
Dcaf6	XP_036009808.1	WD40	43..>292	CDD:475233	83/261 (32%)
		WD40 repeat	55..92	CDD:293791	13/36 (36%)
		WD40 repeat	97..138	CDD:293791	14/40 (35%)
		WD40 repeat	148..181	CDD:293791	11/32 (34%)
		WD40 repeat	188..233	CDD:293791	17/49 (35%)
		WD40 repeat	256..282	CDD:293791	8/25 (32%)
		WD40	<838..897	CDD:475233	27/60 (45%)