Protein Alignment adp and DCAF6

DIOPT Version :10

• Sequence 1: NP_611296.2
• Gene: adp / 37073
• FlyBaseID: FBgn0000057
• Length: 628
• Species: Drosophila melanogaster
• Sequence 2: NP_001185885.1
• Gene: DCAF6 / 55827
• HGNCID: 30002
• Length: 951
• Species: Homo sapiens
• Alignment Length: 918
• Identity: 195/918 - (21%)
• Similarity: 301/918 - (32%)
• Gaps: 362/918 - (39%)

  Fly    28 LHW--QRQQYGHELDEMLRRRLLASPAYVDRLEQEAVLVGHEGCVNCLEWTTDGMWLASGSDDYR 90
            |.|  :::..|.|....||.|.|....::.||:.||.|..|:||||.:.|...|.::.|||||.:
Human    10 LLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTK 74

  Fly    91 VMIWDPFRKKLVHVIRTKHLGNVFSVKFLPKTNNSIVATCAADKFIYVYDINDPNETLFSC--IC 153
            ::|.:|:.:|::..||:.|..|:||.||||.||:..:.:|:.|..|:..::....||...|  .|
Human    75 LVISNPYSRKVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTC 139

  Fly   154 HFSRAKRLATAQDSPHVFWSAGEDGCILQLDIREPHRCRPEEGIGVRLLNLHDQLENTEAKCLAI 218
            |:.....:.|..:.|:.|.|.||||.:...|.|....|..|:.....|:|.     ...|..:||
Human   140 HYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINC-----RRAATSVAI 199

  Fly   219 NPRRTEYLAVGTNDPFARVYDRRKLPST-----NGNGLSACVAYYAPGQIVKNISRNIVHEPRGI 278
            .|....|||||.:|...|:||||.|.:.     .|.|.:..||.:.|..:.....|        :
Human   200 CPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCR--------V 256

  Fly   279 TYLTFNGNGTELLVNIGCEHVYRFDLNH------------------AEPPV-------------- 311
            |.|.::.:|.|:||:...:::|.||...                  .:|||
Human   257 TSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGP 321

  Fly   312 --------------------FYDLPAFTSTLVHEEEPVKMPHRSR---------------SLPT- 340
                                ...:....|....|...|...:|.|               :|||
Human   322 RARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTV 386

  Fly   341 ----EIEVYK------KEGNDFLE-----------NGKLVDAIDAYSAALAKYPQGEVL------ 378
                ::||.:      .....||:           :.........:|..|...|..|..
Human   387 PSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEAS 451

  Fly   379 --YLNRATALMRRGWFGDIYAALRDCHEALRLDPSYVKAHFRLA--------------------- 420
              :.:..:..:|    |...|.||...:.|||..:..:....||
Human   452 GHHTHHQSEFLR----GPEIALLRKRLQQLRLKKAEQQRQQELAAHTQQQPSTSDQSSHEGSSQD 512

  Fly   421 --------------------------------------RALLELH-------------------- 427
                                                  ..:|.||
Human   513 PHASDSPSSVVNKQLGSMSLDEQQDNNNEKLSPKPGTGEPVLSLHYSTEGTTTSTIKLNFTDEWS 577

  Fly   428 ----------------------------RPQDADQCLQALIQRFPDF------------ANNH-G 451
                                        :|.:.|...:|..:...|.            ..|| .
Human   578 SIASSSRGIGSHCKSEGQEESFVPQSSVQPPEGDSETKAPEESSEDVTKYQEGVSAENPVENHIN 642

  Fly   452 VLMLNK--------------DIKENR-----------RQSKSPEA----------------PE-- 473
            :...:|              |:..:|           .::|.||.                ||
Human   643 ITQSDKFTAKPLDSNSGERNDLNLDRSCGVPEESASSEKAKEPETSDQTSTESATNENNTNPEPQ 707

  Fly   474 --------------------LQPVEVDD-------GFRYLRLKNAEYDLRSTA------------ 499
                                ||..:..|       |.||.......:::|.|.
Human   708 FQTEATGPSAHEETSTRDSALQDTDDSDDDPVLIPGARYRAGPGDRFNIRGTTIGDRIMRRSAVA 772

  Fly   500 --RDYMQR-----------------------YVGHCNVTTDIKEANYLGSQGEFIAAGSDDGNMY 539
              :::.:|                       |.||.|..|.|||||:.|:  .|:.:|||.|:::
Human   773 RIQEFFRRRKERKEMEELDTLNIRRPLVKMVYKGHRNSRTMIKEANFWGA--NFVMSGSDCGHIF 835

  Fly   540 IWEGDTGKIRAVYRADSAIVNCVQPHPSICMLATSGIDHNIKIWSPCAAS-------AEE---RP 594
            ||:..|.:...:..||:.:|||:||||...:||:||||::||||||...|       |:|   |.
Human   836 IWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWSPLEESRIFNRKLADEVITRN 900

  Fly   595 NLVADVTR 602
            .|:.:.||
Human   901 ELMLEETR 908

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
adp	NP_611296.2	WD40	54..>242	CDD:475233	68/189 (36%)
		WD40 repeat	72..108	CDD:293791	12/35 (34%)
		WD40 repeat	114..154	CDD:293791	14/41 (34%)
		WD40 repeat	158..203	CDD:293791	13/44 (30%)
		WD40 repeat	214..268	CDD:293791	20/58 (34%)
		Spy	338..>461	CDD:443119	32/286 (11%)
		TPR repeat	342..370	CDD:276809	5/44 (11%)
		TPR repeat	375..408	CDD:276809	7/40 (18%)
		TPR repeat	413..441	CDD:276809	8/134 (6%)
		WD40 repeat	513..553	CDD:293791	15/39 (38%)
		WD40	<526..584	CDD:475233	26/57 (46%)
DCAF6	NP_001185885.1	WD40	43..>292	CDD:475233	83/261 (32%)
		WD 1	49..88		15/38 (39%)
		WD40 repeat	55..92	CDD:293791	13/36 (36%)
		WD 2	92..133		15/40 (38%)
		WD40 repeat	97..138	CDD:293791	14/40 (35%)
		WD 3	139..179		13/39 (33%)
		WD40 repeat	148..181	CDD:293791	11/32 (34%)
		WD40 repeat	188..233	CDD:293791	17/49 (35%)
		WD 4	189..229		17/44 (39%)
		WD 5	251..290		10/46 (22%)
		WD40 repeat	256..282	CDD:293791	8/25 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	288..340		3/51 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..392		7/36 (19%)
		PRK12323	<394..743	CDD:481241	37/352 (11%)
		WD40	<821..880	CDD:475233	27/60 (45%)