Protein Alignment adp and Dcaf8

DIOPT Version :10

• Sequence 1: NP_611296.2
• Gene: adp / 37073
• FlyBaseID: FBgn0000057
• Length: 628
• Species: Drosophila melanogaster
• Sequence 2: NP_001014253.1
• Gene: Dcaf8 / 364050
• RGDID: 1308513
• Length: 591
• Species: Rattus norvegicus
• Alignment Length: 597
• Identity: 141/597 - (23%)
• Similarity: 214/597 - (35%)
• Gaps: 239/597 - (40%)

  Fly    43 LRRRLLASPA-----------YVDRLEQEAVLVGHEGCVNCLEWTTDGMWLASGSDDYRVMIWDP 96
            ||.|.|.|.|           :|.|...:..|.||.||||.|.:...|.||||||||.:|::||.
  Rat   152 LRERELGSSARFVYEACGARVFVQRFRLQHGLEGHTGCVNTLHFNQRGTWLASGSDDLKVVVWDW 216

  Fly    97 FRKKLVHVIRTKHLGNVFSVKFLPKTNNSIVATCAADKFIYVYDINDPNETLFSCIC-------- 153
            .|::.|....:.|..|||..||||.:.:|.:|.||.|..:.|.::     :...| |
  Rat   217 VRRQPVLDFESGHKSNVFQAKFLPNSGDSTLAMCARDGQVRVAEL-----SATQC-CKNTKRVAQ 275

  Fly   154 HFSRAKRLATAQDSPHVFWSAGEDGCILQLDIREPHRCRPEEGIGVRLLNLHDQLENTEAKCLAI 218
            |...:.:||...|||..|.|||||..:..:|:|:.   ||..    :|:...::.:......:.:
  Rat   276 HKGASHKLALEPDSPCTFLSAGEDAVVFTIDLRQD---RPAS----KLVVTKEKEKKVGLYTIYV 333

  Fly   219 NPRRTEYLAVGTNDPFARVYDRRKLPSTNGNGLSACVAYYAPGQIVKNISRNIVHEPRGITYLTF 283
            ||..|...|||..|.|.|:||:||:.....||:   :..:.|..:|.:.|:      ..||.|.:
  Rat   334 NPANTHQFAVGGRDQFVRIYDQRKIDENENNGV---LKKFCPHHLVNSESK------ANITCLVY 389

  Fly   284 NGNGTELLVNIGCEHVYRFDLNHAEPPVFYDLPAFTSTLVHEEEPVKMPHRSRSLPTEIEVYKKE 348
            :.:|||||.:...|.:|.|:.:|:
  Rat   390 SHDGTELLASYNDEDIYLFNSSHS----------------------------------------- 413

  Fly   349 GNDFLENGKLVDAIDAYSAALAKYPQGEVLYLNRATALMRRGWFGDIYAALRDCHEALRLDPSYV 413
                                                                             
  Rat   414 ----------------------------------------------------------------- 413

  Fly   414 KAHFRLARALLELHRPQDADQCLQALIQRFPDFANNHGVLMLNKDIKENRRQSKSPEAPELQPVE 478
                                                                             
  Rat   414 ----------------------------------------------------------------- 413

  Fly   479 VDDGFRYLRLKNAEYDLRSTARDYMQRYVGHCNVTTDIKEANYLGSQGEFIAAGSDDGNMYIWEG 543
              ||.:|::                 ||.||.|..| :|..|:.|.:.||:.:|||.|::::||.
  Rat   414 --DGAQYIK-----------------RYKGHRNNAT-VKGVNFYGPKSEFVVSGSDCGHIFLWEK 458

  Fly   544 DTGKIRAVYRAD-SAIVNCVQPHPSICMLATSGIDHNIKIWSPCAASAEERPNLVADVTRFVEDN 607
            .:.:|......| ..:|||::|||.:.:|||||:||::|||:|.|.::.|...| .||.:
  Rat   459 SSCQIIQFMEGDKGGVVNCLEPHPHLPVLATSGLDHDVKIWAPTAEASTELTGL-KDVIK----- 517

  Fly   608 QEKMRLDPFELH 619
            :.|...|...||
  Rat   518 KNKRERDEDSLH 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
adp	NP_611296.2	WD40	54..>242	CDD:475233	68/195 (35%)
		WD40 repeat	72..108	CDD:293791	15/35 (43%)
		WD40 repeat	114..154	CDD:293791	13/47 (28%)
		WD40 repeat	158..203	CDD:293791	16/44 (36%)
		WD40 repeat	214..268	CDD:293791	17/53 (32%)
		Spy	338..>461	CDD:443119	0/122 (0%)
		TPR repeat	342..370	CDD:276809	0/27 (0%)
		TPR repeat	375..408	CDD:276809	0/32 (0%)
		TPR repeat	413..441	CDD:276809	0/27 (0%)
		WD40 repeat	513..553	CDD:293791	13/39 (33%)
		WD40	<526..584	CDD:475233	25/58 (43%)
Dcaf8	NP_001014253.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..140
		Nuclear export signal. /evidence=ECO:0000250|UniProtKB:Q5TAQ9	39..50
		WD40	183..500	CDD:475233	122/529 (23%)
		WD 1	185..224		21/38 (55%)
		WD40 repeat	192..228	CDD:293791	15/35 (43%)
		WD 2	228..269		16/46 (35%)
		WD40 repeat	234..275	CDD:293791	13/46 (28%)
		WD 3	275..315		16/46 (35%)
		WD40 repeat	280..321	CDD:293791	16/47 (34%)
		WD 4	323..363		13/39 (33%)
		WD40 repeat	329..377	CDD:293791	16/50 (32%)
		WD 5	379..418		15/217 (7%)
		WD40 repeat	384..423	CDD:293791	16/228 (7%)
		WD 6	426..466		14/40 (35%)
		WD40 repeat	431..468	CDD:293791	12/36 (33%)
		WD 7	470..509		19/38 (50%)
		WD40 repeat	475..499	CDD:293791	14/23 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	552..591