Protein Alignment adp and DCAF8L2

DIOPT Version :10

• Sequence 1: NP_611296.2
• Gene: adp / 37073
• FlyBaseID: FBgn0000057
• Length: 628
• Species: Drosophila melanogaster
• Sequence 2: XP_054182971.1
• Gene: DCAF8L2 / 347442
• HGNCID: 31811
• Length: 632
• Species: Homo sapiens
• Alignment Length: 625
• Identity: 133/625 - (21%)
• Similarity: 214/625 - (34%)
• Gaps: 253/625 - (40%)

  Fly    33 QQYGHELDEML-----------------------RRRLLASP----------AYVDRLEQEAVLV 64
            :||..|.|:.|                       :|:|.:.|          |:|.|...:..|.
Human   162 EQYSLEEDQALEEWVSSETSALPRPRWQVVTALHQRQLGSRPRFVYEACGARAFVQRFRLQYRLA 226

  Fly    65 GHEGCVNCLEWTTDGMWLASGSDDYRVMIWDPFRKKLVHVIRTKHLGNVFSVKFLPKTNNSIVAT 129
            .|.||||.:.:...|..|||..||.:|::||..|::.|....:.|..|||..||||...:|.:|.
Human   227 DHVGCVNTVHFNQRGTRLASSGDDLKVIVWDWVRQRPVLNFESGHTNNVFQAKFLPNCGDSTLAM 291

  Fly   130 CAADKFIYVYDINDPNETLFS---CIC-HFSRAKRLATAQDSPHVFWSAGEDGCILQLDIREPHR 190
            ||.|..:.|.::  .|.:.|:   |:. |...|.:||...|||:.|.::|||..:..:|:|:.
Human   292 CARDGQVRVAEL--INASYFNNTKCVAQHRGPAHKLALEPDSPYKFLTSGEDAVVFTIDLRQD-- 352

  Fly   191 CRPEEGIGVRLLNLHDQLENTEAKCLAINPRRTEYLAVGTNDPFARVYDRRKLPSTNGNGLSACV 255
             ||...:.|    ..:..:......:.:||..|...|||..|.|.|:||:||:.....||:   :
Human   353 -RPASKVVV----TRENDKKVGLYTITVNPANTYQFAVGGQDQFVRIYDQRKIDKKENNGV---L 409

  Fly   256 AYYAPGQIVKNISRNIVHEPRGITYLTFNGNGTELLVNIGCEHVYRFDLNHAEPPVFYDLPAFTS 320
            ..:.|..:|.      ...|..||.:.::.:|||||.:...:.:|.|:.:|:
Human   410 KKFTPHHLVN------CDFPTNITCVVYSHDGTELLASYNDDDIYLFNSSHS------------- 455

  Fly   321 TLVHEEEPVKMPHRSRSLPTEIEVYKKEGNDFLENGKLVDAIDAYSAALAKYPQGEVLYLNRATA 385
                                                                             
Human   456 ----------------------------------------------------------------- 455

  Fly   386 LMRRGWFGDIYAALRDCHEALRLDPSYVKAHFRLARALLELHRPQDADQCLQALIQRFPDFANNH 450
                                                                             
Human   456 ----------------------------------------------------------------- 455

  Fly   451 GVLMLNKDIKENRRQSKSPEAPELQPVEVDDGFRYLRLKNAEYDLRSTARDYMQRYVGHCNVTTD 515
                                          ||                 ..|.:|:.||.|.||
Human   456 ------------------------------DG-----------------AQYSKRFKGHRNNTT- 472

  Fly   516 IKEANYLGSQGEFIAAGSDDGNMYIWEGDTGKIRAVYRAD-SAIVNCVQPHPSICMLATSGIDHN 579
            :|..|:.|.:.||:.:|||.|:::.||..:.:|....:.. ...:||::|||.:.:||.||:||:
Human   473 VKGVNFYGPRSEFVVSGSDCGHIFFWEKSSCQIIQFLKGSREGTINCLEPHPYLPVLACSGLDHD 537

  Fly   580 IKIWSPCAASAEERPNLVADVTRFVEDNQEKMRLDPFELH 619
            :|||:|.|.:|.|    :..:.:.::.|  |...|...||
Human   538 VKIWTPTAKAATE----LTGLKKVIKKN--KWERDEDSLH 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
adp	NP_611296.2	WD40	54..>242	CDD:475233	63/191 (33%)
		WD40 repeat	72..108	CDD:293791	11/35 (31%)
		WD40 repeat	114..154	CDD:293791	14/43 (33%)
		WD40 repeat	158..203	CDD:293791	15/44 (34%)
		WD40 repeat	214..268	CDD:293791	17/53 (32%)
		Spy	338..>461	CDD:443119	0/122 (0%)
		TPR repeat	342..370	CDD:276809	0/27 (0%)
		TPR repeat	375..408	CDD:276809	0/32 (0%)
		TPR repeat	413..441	CDD:276809	0/27 (0%)
		WD40 repeat	513..553	CDD:293791	14/39 (36%)
		WD40	<526..584	CDD:475233	22/58 (38%)
DCAF8L2	XP_054182971.1	WD40	225..541	CDD:475233	111/524 (21%)
		WD40 repeat	234..270	CDD:293791	11/35 (31%)
		WD40 repeat	276..317	CDD:293791	14/42 (33%)
		WD40 repeat	322..363	CDD:293791	15/47 (32%)
		WD40 repeat	371..419	CDD:293791	16/50 (32%)
		WD40 repeat	426..465	CDD:293791	14/228 (6%)
		WD40 repeat	473..510	CDD:293791	12/36 (33%)
		WD40 repeat	517..541	CDD:293791	12/23 (52%)