Protein Alignment adp and Dcaf8l

DIOPT Version :10

• Sequence 1: NP_611296.2
• Gene: adp / 37073
• FlyBaseID: FBgn0000057
• Length: 628
• Species: Drosophila melanogaster
• Sequence 2: NP_032847.2
• Gene: Dcaf8l / 18630
• MGIID: 101758
• Length: 747
• Species: Mus musculus
• Alignment Length: 648
• Identity: 137/648 - (21%)
• Similarity: 220/648 - (33%)
• Gaps: 251/648 - (38%)

  Fly    17 QRQHTPLNASSLHWQRQQYGHELDEM----------------------LRRRLLASPA------- 52
            |.:.:.::..:.....:||..|.|.:                      ||.|.|.|..
Mouse   270 QEESSEMHEETSEDSSEQYDIEDDSLIDEWIALETSPLPRPRWNVLSALRDRQLGSSGRFVYEAC 334

  Fly    53 ----YVDRLEQEAVLVGHEGCVNCLEWTTDGMWLASGSDDYRVMIWDPFRKKLVHVIRTKHLGNV 113
                :|.|...|.|..||.||||.:.:...|..|||||||.:|::||..:|:.|....:.|..|:
Mouse   335 GARLFVQRFSLEHVFEGHSGCVNTVHFNQHGTLLASGSDDLKVIVWDWLKKRSVLNFDSGHKNNI 399

  Fly   114 FSVKFLPKTNNSIVATCAADKFIYVYDINDPNETLFS--CICHFSRAKRLATAQDSPHVFWSAGE 176
            ...||||..|::|:|.|..|..:.|..::....|..:  .:.|...:.||....|||..|.::||
Mouse   400 LQAKFLPNCNDAILAMCGRDGQVRVAQLSAVAGTHMTKRLVKHGGASHRLGLEPDSPFRFLTSGE 464

  Fly   177 DGCILQLDIREPHRCRPEEGIGVRLLNLHDQLENTEAKCLAINPRRTEYLAVGTNDPFARVYDRR 241
            |..:..:|:|:.|...       :||.:.|..:......:.:||......|||..|.|.|:||:|
Mouse   465 DAVVFNIDLRQAHPAS-------KLLVIKDGDKKVGLYTVFVNPANVYQFAVGGQDQFMRIYDQR 522

  Fly   242 KLPSTNGNGLSACVAYYAPGQIVKNISRNIVHEPRGITYLTFNGNGTELLVNIGCEHVYRFDLNH 306
            |:.....||:   :..:.|..::.:      ..|..||.|.::.:|||:|.:...|.:|.|:
Mouse   523 KIDENVNNGV---LKKFCPHHLLSS------DYPAHITSLMYSYDGTEILASYNDEDIYIFN--- 575

  Fly   307 AEPPVFYDLPAFTSTLVHEEEPVKMPHRSRSLPTEIEVYKKEGNDFLENGKLVDAIDAYSAALAK 371
                                                                             
Mouse   576 ----------------------------------------------------------------- 575

  Fly   372 YPQGEVLYLNRATALMRRGWFGDIYAALRDCHEALRLDPSYVKAHFRLARALLELHRPQDADQCL 436
                                                                     ..|:|
Mouse   576 ---------------------------------------------------------SSDSD--- 580

  Fly   437 QALIQRFPDFANNHGVLMLNKDIKENRRQSKSPEAPELQPVEVDDGFRYLRLKNAEYDLRSTARD 501
                                                                          ...
Mouse   581 --------------------------------------------------------------GAQ 583

  Fly   502 YMQRYVGHCNVTTDIKEANYLGSQGEFIAAGSDDGNMYIWEGDTGKIRAVYRAD-SAIVNCVQPH 565
            |.:||.||.|.:| :|...:.|.:.||:.:|||.|:::|||..:.:|.....|| ...:||:..|
Mouse   584 YAKRYKGHRNNST-VKGVYFYGPRSEFVMSGSDCGHIFIWEKSSCQIVQFLEADEGGTINCIDSH 647

  Fly   566 PSICMLATSGIDHNIKIWSPCAASAEERPNLVADVTRFVEDNQEKMRLDPFELHTRNAYCFNN 628
            |.:.:||:||:||.:|||||.|..:::    :|.:...::.|  |::.|.|.|  |:...|||
Mouse   648 PYLPVLASSGLDHEVKIWSPIAEPSKK----LAGLKNVIKIN--KLKRDNFTL--RHTSLFNN 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
adp	NP_611296.2	WD40	54..>242	CDD:475233	62/189 (33%)
		WD40 repeat	72..108	CDD:293791	13/35 (37%)
		WD40 repeat	114..154	CDD:293791	11/41 (27%)
		WD40 repeat	158..203	CDD:293791	13/44 (30%)
		WD40 repeat	214..268	CDD:293791	15/53 (28%)
		Spy	338..>461	CDD:443119	2/122 (2%)
		TPR repeat	342..370	CDD:276809	0/27 (0%)
		TPR repeat	375..408	CDD:276809	0/32 (0%)
		TPR repeat	413..441	CDD:276809	2/27 (7%)
		WD40 repeat	513..553	CDD:293791	13/39 (33%)
		WD40	<526..584	CDD:475233	24/58 (41%)
Dcaf8l	NP_032847.2	CobT2	<224..>294	CDD:443611	4/23 (17%)
		WD40	345..666	CDD:475233	111/527 (21%)
		WD40 repeat	358..394	CDD:293791	13/35 (37%)
		WD40 repeat	400..441	CDD:293791	11/40 (28%)
		WD40 repeat	446..487	CDD:293791	14/47 (30%)
		WD40 repeat	495..543	CDD:293791	15/50 (30%)
		WD40 repeat	550..589	CDD:293791	14/228 (6%)
		WD40 repeat	597..634	CDD:293791	12/36 (33%)
		WD40 repeat	641..665	CDD:293791	11/23 (48%)