Protein Alignment Pcl and PHF1

DIOPT Version :10

• Sequence 1: NP_476672.1
• Gene: Pcl / 37069
• FlyBaseID: FBgn0003044
• Length: 1043
• Species: Drosophila melanogaster
• Sequence 2: XP_011512964.2
• Gene: PHF1 / 5252
• HGNCID: 8919
• Length: 633
• Species: Homo sapiens
• Alignment Length: 797
• Identity: 186/797 - (23%)
• Similarity: 275/797 - (34%)
• Gaps: 249/797 - (31%)

  Fly   286 EAMSSPGKSSPSPPLLATQSLLKGVNSMKPSFKTVEAAPPTPP-----------TPPSPPPPPPA 339
            |.:.||..|..|.|.....||..|  :::..::..:.|...||           .|.||
Human    31 EGIPSPTGSDSSLPKPRRASLFFG--ALQACWRPPQDAMAQPPRLSRSGASSLWDPASP------ 87

  Fly   340 PPVAAPSPAVTYALQEDVFIKCNDGRFYLGTI--IDQTSDQYLIRFDDQSE---QWCEPDKLRKL 399
            .|.:.|.|.:...  :||..:..||..|||||  :|...:..|::|:|.|:   .|
Human    88 APTSGPRPRLWEG--QDVLARWTDGLLYLGTIKKVDSAREVCLVQFEDDSQFLVLW--------- 141

  Fly   400 GGGSSITAGGGGASTTESTNTSPSG-P----MCVACKRSDIEDVVE-----ICERCGRGYHRGCT 454
                              .:.||:. |    :|..|:.   |.||.     .||:|...||:.|.
Human   142 ------------------KDISPAALPGEELLCCVCRS---ETVVPGNRLVSCEKCRHAYHQDCH 185

  Fly   455 VEIVTGSG-----IWSCKRCAKPMKMQQ-------PVSHKITKPAGICRQLPYHADKLSWDEKHR 507
            |......|     .|.|::|...:..::       |.:..:   .|:...|||....|.||..|.
Human   186 VPRAPAPGEGEGTSWVCRQCVFAIATKRGGALKKGPYARAM---LGMKLSLPYGLKGLDWDAGHL 247

  Fly   508 VNEEQIYCYCGKPGKFDHNMLQCCKCRNWFHTQCMQNFKKKLLRGDMFFVFCCTVCNNGIEFVRR 572
            .|.:|.|||||.||:::..||||..|..|||..|.|...|.||.||.|:.|.|.||..|.|.|||
Human   248 SNRQQSYCYCGGPGEWNLKMLQCRSCLQWFHEACTQCLSKPLLYGDRFYEFECCVCRGGPEKVRR 312

  Fly   573 MQIEWVDVLHIALYNLRKHQHQKYHHLLNDIWPFILEQRHQLPICEKWRTLPETALMERLKQTLK 637
            :|:.||||.|:.||:|.....:||.....:|.||..|....|.:.|...| |:.....||...|.
Human   313 LQLRWVDVAHLVLYHLSVCCKKKYFDFDREILPFTSENWDSLLLGELSDT-PKGERSSRLLSALN 376

  Fly   638 DYSDRFVCGREFKRAPAFYALRHSGPPHIPKVFLEPHEELSDELLEKRFKLMLMPEEPDEGANEL 702
            .:.|||:.|||.|:....:.|....||                           |.||..|...|
Human   377 SHKDRFISGREIKKRKCLFGLHARMPP---------------------------PVEPPTGDGAL 414

  Fly   703 PK---------RVPKDVYEFNTDEDDPVETSE----DEIPIKQIIEKAKKQAAQKADKHDELPLK 754
            ..         .|.:.:.:....|.:|:...:    :|:.....:....:...|:...|.:..|:
Human   415 TSFPSGQGPGGGVSRPLGKRRRPEPEPLRRRQKGKVEELGPPSAVRNQPEPQEQRERAHLQRALQ 479

  Fly   755 PDLADDNANDGDPGKLPAPIPPLLDANSSRKRKAFRLSKRYDNSRNHCDLSSDENSSSSRGTSSL 819
            ..::.           |:|.|                                  :.|.:|:|.
Human   480 ASVSP-----------PSPSP----------------------------------NQSYQGSSG- 498

  Fly   820 DLIIPPPVNFLGRNNPFLMATPKKASQGRSISVGTGVGVNGIINSIFKLKGTSKEQPRMVRTIKR 884
                   .||...:...|.::|.:.......|..|.              |||.:.....|
Human   499 -------YNFRPTDARCLPSSPIRMFASFHPSASTA--------------GTSGDSGPPDR---- 538

  Fly   885 RLSAKDITIGPNQEVRRRRTRRLTTAIEVISTTTINPIPSHYLPIYAKDLQPPAPPMGKPTHGRL 949
              |..::.||...::.:.....:|.:...:|:      ||..||
Human   539 --SPLELHIGFPTDIPKSAPHSMTASSSSVSS------PSPGLP--------------------- 574

  Fly   950 LRQRPQKQSPSQSRRNSTSSTATSSSSNGIGAPGHSMLDLKQSVNKYFGGAMNRIDAGEPFAIRA 1014
                         ||::..|....|.|.|.|..              ..|.:..:..|:|..:.|
Human   575 -------------RRSAPPSPLCRSLSPGTGGG--------------VRGGVGYLSRGDPVRVLA 612

  Fly  1015 KRRMGNGQVQYLVEWGG 1031
            :|...:|.|||||||||
Human   613 RRVRPDGSVQYLVEWGG 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pcl	NP_476672.1	PRK12323	<13..107	CDD:481241
		Tudor_dPCL-like	350..401	CDD:410523	15/55 (27%)
		PHD_SF	426..469	CDD:473978	15/52 (29%)
		PHD2_MTF2_PHF19_like	514..565	CDD:276978	27/50 (54%)
		Mtf2_C	985..1033	CDD:464077	15/47 (32%)
PHF1	XP_011512964.2	Tudor_PHF1	96..148	CDD:410520	17/80 (21%)
		PHD1_PHF1	155..205	CDD:276975	15/52 (29%)
		PHD2_PHF1	254..305	CDD:277057	27/50 (54%)
		Mtf2_C	<602..631	CDD:464077	14/28 (50%)