Protein Alignment Pcl and Phf19

DIOPT Version :10

• Sequence 1: NP_476672.1
• Gene: Pcl / 37069
• FlyBaseID: FBgn0003044
• Length: 1043
• Species: Drosophila melanogaster
• Sequence 2: NP_001100040.1
• Gene: Phf19 / 296653
• RGDID: 1310390
• Length: 578
• Species: Rattus norvegicus
• Alignment Length: 792
• Identity: 195/792 - (24%)
• Similarity: 285/792 - (35%)
• Gaps: 253/792 - (31%)

  Fly   277 TPQTPPTTPEAM--SSPGKSSPSPPLLATQSLLKGVNSMKPSFKTVEAAPPTPPTPPSPPPPPPA 339
            |....|.|.||.  :||.|.:||              ..|.:||.:.:
  Rat     3 TQALEPGTQEAFGATSPNKGAPS--------------KTKKNFKDLMS----------------- 36

  Fly   340 PPVAAPSPAVTYALQEDVFIKC--NDGRFYLGTI--IDQTSDQYLIRFDDQSEQWCEPDKLRKLG 400
                        .:.|..|:.|  .||.:|||.|  :.......|:.|:|.|:.|.....::.
  Rat    37 ------------KVTEGQFVLCRWTDGLYYLGKIKRVSSPKQSCLVTFEDNSKYWVLWKDIQH-- 87

  Fly   401 GGSSITAGGGGASTTESTNTSPSGPMCVAC--KRSDIEDVVEICERCGRGYHRGCTVEIVTGSG- 462
                  ||..|..           |.|..|  |.|...:.:.||.:||.|||:.|.:.|...:.
  Rat    88 ------AGVPGEE-----------PKCDVCMGKTSGPMNEILICGKCGLGYHQQCHIPIAVDANW 135

  Fly   463 ----IWSCKRCAKPMKMQQPVSHK---ITKPAGICRQ-LPYHADKLSWDEKHRVNEEQIYCYCGK 519
                .|.|:||...:.:::..:.|   |.|.....:. |.|..::|.||..||.|::|.|||||.
  Rat   136 PLLTHWFCRRCIFALAVRKGGALKKGAIAKTLQAVKMVLSYQPEELDWDSPHRTNQQQCYCYCGG 200

  Fly   520 PGKFDHNMLQCCKCRNWFHTQCMQNFKKKLLRGDMFFVFCCTVCNNGIEFVRRMQIEWVDVLHIA 584
            ||::...||||.:||.|||..|.|...:.::.||.|::|.|:|||.|.|::.|:.:.|||::|:|
  Rat   201 PGEWYLRMLQCYRCRQWFHEACTQCLSEPMVFGDRFYLFFCSVCNQGPEYIERLPLRWVDIVHLA 265

  Fly   585 LYNLRKHQHQKYHHLLNDIWPFILEQRHQLPICE--KWRTLPETALMERLKQTLKDYSDRFVCGR 647
            ||||.....::|.. ..:|..|:   .|...:.:  |..:.|.|.....|...|..|..||:||:
  Rat   266 LYNLGVQSKKRYFD-FEEILAFV---NHHWELLQLGKLTSTPVTERGPHLLNALNSYKSRFLCGK 326

  Fly   648 EFKRAPAFYALRHSGPPHIPKVFLE-----PHEELSDELLEKRFKLM--LMPEEPDEGANELPKR 705
            |.|:....:.||...||..|...|.     |.::.:.|||.||.|..  |:|:|..:....:.:|
  Rat   327 EIKKKKCIFRLRVRVPPAPPGKLLPDRAQMPSDKGTFELLRKRGKSKPGLLPQESQQQKRRVYRR 391

  Fly   706 VPKDVYEFNTDEDDPVETSEDEIPIKQIIEKAKKQAAQKADKH---------DELPLKPDLADDN 761
            .....            ..||.||....      .:|...|.|         ||:        .:
  Rat   392 KRSKF------------LLEDAIPSSDF------TSAWSTDHHLASIFDFTLDEI--------QS 430

  Fly   762 ANDGDPGKLPAPIPPLLDANSSRKRKAFRLSKRYDNSRNHCDLSSDENSSSSRGTSSLDLIIPPP 826
            ...|..|                  :.|           ..|:.|.:.:|:| |::|..|
  Rat   431 LKSGSSG------------------QTF-----------FSDVDSTDAASTS-GSASTSL----- 460

  Fly   827 VNFLGRNNPFLMATPKKASQGRSISVGTGVGVNGIINSIFKLKGTSKEQPRMVRTIKRRLSAKDI 891
                              ||....:||:.                           ||:|:||
  Rat   461 ------------------SQDSRWTVGSR---------------------------KRKLAAK-- 478

  Fly   892 TIGPNQEVRRRRTRRLTTAIEVISTTTINPIPSHYLPIYAKDLQPPAPPMGKPTHGRLLRQRPQK 956
                                             .|.|:.||  ...|.|.|:..........|
  Rat   479 ---------------------------------AYRPLRAK--HRAAEPDGRCASDSSAEGAP-- 506

  Fly   957 QSPSQSRRNSTSSTATSSSSNGIGAPGHSMLDLKQSVNKYFGGAMNRIDAGEPFAIRAKRRMGNG 1021
             .|.|......|.|..|     |.....|:..||.|:..|||.| .|:..||.:.:.|:|....|
  Rat   507 -GPEQQDEGIDSHTFES-----ISGDDSSLSHLKSSITNYFGAA-GRLACGEKYQVLARRVTPEG 564

  Fly  1022 QVQYLVEWGGDT 1033
            :||||:||.|.|
  Rat   565 KVQYLLEWEGTT 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pcl	NP_476672.1	PRK12323	<13..107	CDD:481241
		Tudor_dPCL-like	350..401	CDD:410523	14/54 (26%)
		PHD_SF	426..469	CDD:473978	15/49 (31%)
		PHD2_MTF2_PHF19_like	514..565	CDD:276978	25/50 (50%)
		Mtf2_C	985..1033	CDD:464077	21/47 (45%)
Phf19	NP_001100040.1	Tudor_PHF19	37..93	CDD:410522	16/63 (25%)
		PHD_SF	96..148	CDD:473978	17/51 (33%)
		PHD2_PHF19	195..246	CDD:277056	25/50 (50%)
		Mtf2_C	529..576	CDD:464077	21/47 (45%)